Study on the Injectable Magnesium-calcium Phosphate Cements

Injectable magnesium-calcium phosphate cements (IMPC) was prepared using magnesium oxide (MgO), monopotassium phosphate (KH2PO4), β-tricalcium phosphate (β-TCP), glucose and phosphoric acid solution. The effects of liquid to powder ratio(LPR), contents of MgO and glucose on IMPC’s gelling and mechanical properties were investigated. The results showed that increase of LPR and glucose content resulted in increased IMPC setting time and injectability, and decreased compressive strength. With the MgO content decreasing, the setting time and the injectability were decreased, whereas the compressive strength was increased. To obtain optimal formula for the new IMPC, the MgO and glucose contents and LPR were selected based on orthogonal experiments, and the result was 26wt% MgO, 6wt% glucose and 0.30 mL/g LPR. The new IMPC has moderate hydration with low exothermic reaction and ideal hardening performance, indicating that it may be used as a novel bone adhesive material.