Microwave-assisted Solvothermal Synthesis of Calcium Phosphate Microspheres and Polyhedra

Synthetic calcium phosphate (CaP) has been investigated as promising biomaterial due to its excellent biocompatibility. CaP nanosheet-assembled microspheres have been prepared using Ca(CH3COO)2, NaH2PO4•2H2O and PLA−mPEG in aqueous solution by the microwave-assisted hydrothermal method at 120℃ for 30 min. Meanwhile, CaP polyhedral have been prepared using Ca(CH3COO)2, NaH2PO42H2O and PLA−mPEG in mixed solvent of water and ethylene glycol (EG) by the microwave-assisted solvothermal method at 120℃ for 30 min. The products were characterized with X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and thermogravimetric analysis (TG). EG has a significant effect on the chemical composition and morphology of the product. The hemoglobin protein adsorption properties of the as-prepared products are investigated. The Hb adsorption amount increased with increasing Hb initial concentration, and the Hb adsorption amount decreased with increasing volume of EG.