Photothermal Core-Shell TiN@Borosilicate Bioglass Nanoparticles: Degradation and Mineralization

Borosilicate bioglass has attracted extensive attention due to its stable structure and excellent biological activity.However, the rate of its mineralization process is fast in the initial stage and slow in the middle and late stages, which limits the application of borosilicate bioglass.As an auxiliary method, the near-infrared (NIR) laser can accelerate the degradation of bioglass.Therefore, we prepared a core-shell borosilicate bioglass with titanium nitride as the core and bioglass (40SiO 2 -20B 2 O 3 -36CaO-4P 2 O 5 ) as the shell, and used near-infrared laser regulation technology to intervene the mineralization process of the composite bioglass.The experimental results show that the core-shell bioglass exhibits a significant photothermal effect, and the photothermal ability increases with the increases of the doping amount of TiN NPs and the laser power density.During the in vitro immersion, near-infrared laser increased the degradation rate of bioglass.After immersion for 7 d, the contents of calcium and boron in the SBF are increased by 12%-16% and 8%-11%, respectively.Meanwhile, the formation efficiency of hydroxyapatite is significantly improved.Cell proliferation activity test shows that the sample has good biological safety.Therefore, near-infrared light can accelerate the degradation and mineralization of functional core-shell bioactive glass, which is expected to play a regulatory role.