Development and evaluation of a controlled drug delivery wound dressing based on polymeric porous microspheres
Source abstract
Abstract
The aim of the present work was to develop and evaluate a controlled drug delivery wound dressing based on polymeric porous microspheres, which are also termed as microsponge drug delivery system. For this purpose, turmeric (drug)-based polymeric porous microspheres formulations were developed by quasi-emulsion solvent diffusion method. The production yields, actual drug content, drug entrapment efficiency, particle size, formulation of the material, and in vitro release were studied. On the basis of maximum drug released, a formulation was selected to incorporate into wound dressings with the help of a binder by spraying technique. Finally, the selected formulation and samples of wound dressings containing microsponges were subjected to scanning electron microscopy and drug release analyses. The result of in vitro release shows that microsponge drug delivery system is a versatile tool that has a potential to convert any wound dressing into a controlled drug delivery wound dressing.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Wound Healing and Treatments · Polymer Nanocomposite Synthesis and Irradiation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Textile Engineering, Bahauddin Zakariya University, Multan, Pakistan
National Textile University, Faisalabad, Pakistan
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
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