Biodegradable and conductive PVA/CNT nanofibrous membranes used in nerve conduit applications
Source abstract
Abstract
The recovery of impaired peripheral nerves is often not as expected, which makes the development of nerve conduits trendy nowadays. To enable the neural messages effectively being delivered as well as to prevent the secondary damage during the removal of nerve conduits, the conductivity and biodegradability are two essential requirements for ideal nerve conduits. In this study, electrospinning is used to produce polyvinyl alcohol (PVA)/carbon nanotubes (CNT) electrospun films, after which the morphology analysis, electrical property, water contact angle, and biological characteristics of the membranes are investigated, thereby determining the optimal nerve conduits based on the employment of electrospinning, PVA, and CNT. The test results indicate that with 0.25 wt% of PVA, the electrospun films exhibit comparatively lower resistance of 25.3 ohm, good fibrous morphology with a diameter being 1 μm. In addition, the electrospun films are cytotoxicity-free and facilitate the growth of cells. It is observed in the MMT assay that after co-cultured with cells for three days, PVA/CNT electrospinning fibrous membranes exhibit a cellular viability that is 18.5 times greater than that of the control group on Day 1. According to all property evaluations, PVA/CNT electrospinning fibrous membranes are a qualified candidate for the use of nervous conduits.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Nerve injury and regeneration · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Graduate Institute of Biomedical Sciences, China Medical University, China Medical University, Taichung, Taiwan
School of Chinese Medicine, China Medical University, China Medical University, Taichung, Taiwan
Fujian Key Laboratory of Novel Functional Textile Fibers and Materials, Minjiang University, Fuzhou, China
Advanced Medical Care and Protection Technology Research Center, College of Textile and Clothing, Qingdao University, Qingdao, China
Innovation Platform of Intelligent and Energy-Saving Textiles, School of Textiles, Tianjin Polytechnic University, Tianjin, China, Taiwan
Department of Fiber and Composite Materials, Feng Chia University, Taichung, Taiwan
Tianjin and Ministry of Education Key Laboratory for Advanced Textile Composite Materials, Tiangong University, Tianjin, China
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan
Funding
Ministry of Science and Technology, Taiwan · China Medical University
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