Structure and dynamics of lipid membranes interacting with antivirulence end-phosphorylated polyethylene glycol block copolymers
Source abstract
Abstract
The structure and dynamics of lipid membranes in the presence of extracellular macromolecules are critical for cell membrane functions and many pharmaceutical applications. The pathogen virulence-suppressing end-phosphorylated polyethylene glycol (PEG) triblock copolymer (Pi-ABAPEG) markedly changes the interactions with lipid vesicle membranes and prevents PEG-induced vesicle phase separation in contrast to the unphosphorylated copolymer (ABAPEG). Pi-ABAPEG weakly absorbs on the surface of lipid vesicle membranes and slightly changes the structure of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) unilamellar vesicles at 37 °C, as evidenced by small angle neutron scattering. X-ray reflectivity measurements confirm the weak adsorption of Pi-ABAPEG on DMPC monolayer, resulting in a more compact DMPC monolayer structure. Neutron spin-echo results show that the adsorption of Pi-ABAPEG on DMPC vesicle membranes increases the membrane bending modulus κ.
Source: openalex_inverted_index · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Lipid Membrane Structure and Behavior · Force Microscopy Techniques and Applications · Nanopore and Nanochannel Transport Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Centre for Molecular Engineering and Materials Science Division
Argonne National Laboratory
Lemont
USA
Pritzker School of Molecular Engineering, University of Chicago
NIST Centre for Neutron Research, National Institute of Standards and Technology
Gaithersburg
Centre for Exploration of Energy and Matter, Indiana University
Bloomington
Centre for Advanced Radiation Sources, University of Chicago
Chicago
James Franck Institute, University of Chicago
Centre for Nanophase Materials Sciences
Oak Ridge National Laboratory
Oak Ridge
Advanced Photon Source
Department of Chemical and Biomolecular Engineering
Centre for Neutron Science
Biology and Soft Matter Division
Funding
U.S. Department of Energy · National Institute of Standards and Technology · National Science Foundation
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