Synthesis and characterization of polyacrylamide-based antibacterial hydrogel nanocomposite

In this research, the hydrogel nanocomposites based on acryl amide containing penicillin 800, 1200, Ag, and ZnO nanoparticles as wound dressing applications have been studied. In this work, the preparation was done via a reaction of optimal values to produce an antibacterial hydrogel nanocomposite. The hydrogel was obtained in an aqueous medium by using reagents such as acrylamide, potassium persulfate, and methylene bisacrylamide crosslinker, Ag, ZnO nanoparticles, and penicillins and then, the products were dried as white powders. The properties such as swelling rate, pH sensitivity, and high water swelling capacity of the swelling rate study of the hydrogel showed a high absorption rate of water in pH about 3–4. The effect of temperature on the percentage of hydrogel swelling was shown to swell with increasing temperature and the absorption capacity of polyacrylamide hydrogels decreased with increasing NaCl concentration. The chemical structure of hydrogel was confirmed by FTIR spectrum, and the morphology of synthesized hydrogel surfaces was studied via SEM. The antibacterial studies were done in blood, agar, chocolate, and Müller medium via three methods, first on gram-negative bacteria E. coli and Klebsiella, second in urine medium, and third in drug medium. This polymeric blend can be used as a new wound dressing compound.