Colloidal Dispersions of Lipids and Curcumin, and the Solubility and Degradation Kinetics of the Latter in Micellar Solution

A simple but potentially useful technique has been used to prepare colloidal dispersions of weakly soluble cholesterol(CS), Dipalmitoyl-Phosphocholine (DPPC), hexadecane dioic acid (HDA) and curcumin (CM) stabilized by the surfactants, SDS, NaC, CTAB, Tween-20, and NaDA at their critical micelle concentrations (CMC). The dispersions of DPPC were also vesicles (or liposomes); their nature, shape, and size were characterized and determined by flourimetry, dynamic light scattering (DLS), and field emission scanning electron microscopy (FESEM) methods. The solubility of CM in the micellar solution of concentrations, 1 to 10 CMC was also studied. The kinetics of degradation (instability) of the CM in basic medium in micellar solutions was investigated. The findings on the biologically important materials have been analyzed and presented.