In vitroRelease Behavior of Bovine Serum Albumin from Alginate/P(CE-MAA-MEG) Composite Hydrogel
Source abstract
Abstract
Abstract In this work, pH-sensitive P(CE-MAA-MEG) hydrogel coated with alginate-Ca2+ layer was successfully developed, which might be potential application for oral protein/vaccine delivery system. Morphology, swelling behavior, and in vitro release behavior of the alginate/P(CE-MAA-MEG) composite hydrogel were studied in detail. The results confirmed that the alginate/P(CE-MAA-MEG) composite hydrogel showed great pH-sensitivity. The fact that Bovine Serum Albumin (BSA) was released slowly in acidic environment while it was released quickly in neutral medium suggested that the composite hydrogel might be a candidate for protein drugs via oral administration. Keywords: BiodegradableHydrogel in vitro releasepH sensitive ACKNOWLEDGMENTS This work was financially supported by National 863 project (2007AA021902), National Natural Science Foundation of China (NSFC20704027 and NSFC30700996), Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP 200806100065), New Century Excellent Talents in University (NCET-08-0371), and Chinese Key Basic Research Program (2010CB529906).
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Drug Delivery Systems · Hydrogels: synthesis, properties, applications · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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