Development of Peptide Conjugated Chlorogenic Acid Nanoassemblies for Targeting Tumorigenic Cells

Nanoassemblies were developed from the natural polyphenol chlorogenic acid (CGA) to create targeted drug delivery vehicles for the antitumor drug Topotecan. To specifically target tumor cells, we functionalized the formed assemblies with a tumor targeting peptide. Release profiles showed an initial burst release followed by sustained release up to 140 minutes for the fibrillar assemblies. Nanovesicles released the drug slower. Cell proliferation studies indicated that while chondrocytes continued to grow, tumor cells showed blebbing and their proliferation was significantly reduced in the presence of the drug loaded assemblies. Thus, we have developed new nanoassemblies for selective targeting of tumor cells.