In-silico modeling of early-stage biofilm formation
Source abstract
Abstract
Bacteria can form biofilms in different environmental conditions, e.g. pH, temperature, nutrients, etc. Biofilm growth, therefore, is an extremely robust process. Because of this, while biofilm growth is a complex process affected by several variables, insights into biofilm formation could be obtained by studying simple schematic models. In this manuscript, we describe a hybrid molecular dynamics and Monte Carlo model for the simulation of the early stage formation of a biofilm, to explicitly demonstrate that it is possible to account for most of the processes expected to be relevant. The simulations account for the growth and reproduction of the bacteria, for their interaction and motility, for the synthesis of extracellular polymeric substances and exopolisaccharide trails. We describe the effect of these processes on the early stage formation of biofilms, in two dimensions, and also discuss preliminary three-dimensional results.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Microbial Community Ecology and Physiology · Methane Hydrates and Related Phenomena
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore
Departamento De Estructura De La Materia, Fisica Termica Y Electronica, Facultad De Ciencias Fisicas, Universidad Complutense De Madrid, Madrid, Spain
Departamento de Ingenieria Fisica, Division de Ciencias e Ingenierias, Universidad De Guanajuato, Loma del Bosque, Leon, Mexico
Instituto De Investigación Biomédica Hospital 12 De Octubre (imas12), Madrid, Spain
Departamento De Qumica Física, Universidad Complutense De Madrid, Madrid, Spain
Department of Food Technology, Veterinary Faculty, Universidad Complutense De Madrid, Madrid, Spain
CNR–SPIN, Dipartimento Di Scienze Fisiche, Universita’ Di Napoli Federico II, Napoli, Italy
Funding
Ministry of Education - Singapore
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