journal article·2026-03Open access

Cover Feature: Ions as Architects of DNA Nanostructures: Mechanisms, Simulations, and Technological Frontiers (Small Struct. 3/2026)

Sergiy Perepelytsya, Dmytro Piatnytskyi, Tetiana Bubon, Narcis Cibotariu, Aatto Laaksonen, Francesca Mocci

Small Structures· Volume 7· Issue 3

Abstract

DNA Nanostructures Ions act as key regulators of DNA nanostructures. In their Review (10.1002/sstr.202500786), Sergiy Perepelytsya, Aatto Laaksonen, Francesca Mocci, and co-workers highlight how diverse ion–DNA interactions govern DNA condensation, stability, and nanoscale organization. These mechanisms underpin technologies including DNAzymes, DNA batteries, metallized DNA nanowires, nanopore sensing platforms, and programmable DNA nanostructures, demonstrating how ionic environments guide the design of functional nanoscale systems.
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Research context

OpenAlex topics: Nanopore and Nanochannel Transport Studies · Advanced biosensing and bioanalysis techniques · Gold and Silver Nanoparticles Synthesis and Applications

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Affiliations

Bogolyubov Institute for Theoretical Physics of the National Academy of Sciences of Ukraine Kyiv Ukraine

Kyiv Academic University Kyiv Ukraine

Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS) DEA University of Trieste Trieste Italy

Centre of Advanced Research in Bionanoconjugates and Biopolymers “Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy Iasi Romania

Department of Chemistry Division of Physical Chemistry Arrhenius Laboratory Stockholm University Stockholm Sweden

State Key Laboratory of Materials‐Oriented and Chemical Engineering Nanjing Tech University Nanjing P. R. China

Department of Engineering Sciences and Mathematics Division of Energy Science Luleå University of Technology Luleå Sweden

Department of Chemical and Geological Sciences University of Cagliari Cagliari Italy

References

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