DataVXSmall StructuresPaper
journal article·2025-04Open access

Low‐Intensity Focused Ultrasound‐Responsive, Phase‐Change Nanodroplets to Remodel Macrophage Polarization and Enhance PD‐L1 Blockade Therapy

Qin Zhang, Ci Yin, Junjie Liu, Hua Yang, Yanping Zhang, Qiaoxi Qin, Nianhong Wu, Rui Tang, Yuting Cao, Min Zheng, Hongye He, Hongmei Dong, Yang Zhou, Jianli Ren, Zhengju Ren, Pan Li

Small Structures· Volume 6· Issue 4
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Source abstract

Abstract

Immune checkpoint blockade (ICB) therapy is a promising treatment that has shown significant effects in certain refractory and advanced cancers. However, not all patients respond to ICB therapy. The tumor microenvironment (TME) helps tumors evade immune surveillance and attack, contributing to the low response rate to ICB therapy. M1 macrophages primarily exert antitumor effects within the TME, whereas M2 macrophages support tumor growth and immune evasion through various mechanisms, making them a crucial component of the TME. To reduce M2 macrophages, mitigate TME, and ultimately enhance ICB therapy, perfluoropentane (PFP) is used as the phase‐change material and hematoporphyrin monomethyl ether is incorporated into the nanodroplets (NDs). With mannose modification on their surface, these NDs can effectively target M2 macrophages, denoted as MPH@NDs. When exposed to low‐intensity focused ultrasound, MPH@NDs cause mechanical injury and produce reactive oxygen species. This will lead to remodeling of the distribution of macrophages in the TME, transforming it into a proinflammatory microenvironment. This enhances cytotoxic T lymphocytes accumulation in tumors, remodels TME, and improves PD‐L1 immunotherapy efficacy. MPH@NDs demonstrate promising potential in remodeling the TME, enhancing ICB therapy, and suppressing tumor growth and distant metastasis.
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Research context

Ceramics & glassesNanomaterials

OpenAlex topics: Ultrasound and Hyperthermia Applications · Nanoplatforms for cancer theranostics · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ultrasound The Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 China

Department of Radiology Chongqing Traditional Chinese Medicine Hospital Chongqing 400021 China

Department of Imaging teaching and Research Chongqing College of Traditional Chinese Medicine Chongqing 402760 China

Ultrasound Medical Center Lanzhou University Second Hospital Cuiyingmen No. 82 Chengguan District Lanzhou 730030 China

Gansu Province Clinical Research Center for Ultrasonography Lanzhou University Second Hospital Cuiyingmen No. 82 Lanzhou 730030 China

Chongqing Key laboratory of Ultrasound Molecular Imaging and Therapy Institute of Ultrasound Imaging of Chongqing Medical University Chongqing 400010 China

Department of Anesthesiology Chongqing Traditional Chinese Medicine Hospital Chongqing 400021 China

Department of Ultrasound The Third People's Hospital of Chengdu The Affiliated Hospital of Southwest Jiaotong University Chengdu 610031 China

Department of Ultrasound Women and Children's Hospital of Chongqing Medical University Chongqing 400000 China

Department of Ultrasound, The Third People's Hospital of Chengdu The Affiliated Hospital of SouthwestJiaotong University Chengdu 610031 China

Department of Urology The Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 China

Funding

National Natural Science Foundation of China

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