Ultrasensitive and Closed‐Tube Colorimetric Loop‐Mediated Isothermal Amplification Assay Using Carboxyl‐Modified Gold Nanoparticles
Source abstract
Abstract
LAMP ends up in purple/red: The incorporation of 11-mercaptoundecanoic acid-modified gold nanoparticles into loop-mediated isothermal amplification (LAMP) reaction enables as few as 200 copies of a target DNA sequence to be detected by the naked eye. The color is controlled by magnesium ion-templated aggregation, and in the presence of the target, the LAMP reaction by-product pyrophosphate ion leads to particle deaggregation.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Biosensors and Analytical Detection · Gold and Silver Nanoparticles Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Interdisciplinary Division of Biomedical Engineering The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong China
Department of Health Technology and Informatics The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong China
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