Glioma Therapy: Combination Glioma Therapy Mediated by a Dual‐Targeted Delivery System Constructed Using OMCN–PEG–Pep22/DOX (Small 42/2018)

Wenbo Qian; Min Qian; Yi Wang; Jianfei Huang; Jian Chen; Lanchun Ni; Qingfeng Huang; Qianqian Liu; Peipei Gong; Shiqiang Hou; Hui Zhu; Zhongzheng Jia; Dandan Shen; Changlai Zhu; Rui Jiang; Junlong Sun; Junzhong Yao; Zhongyu Tang; Xiang Ji; Jinlong Shi; Rongqin Huang; Wei Shi

doi:10.1002/smll.201870192

journal article·2018-10Open access

Glioma Therapy: Combination Glioma Therapy Mediated by a Dual‐Targeted Delivery System Constructed Using OMCN–PEG–Pep22/DOX (Small 42/2018)

Wenbo Qian, Min Qian, Yi Wang, Jianfei Huang, Jian Chen, Lanchun Ni, Qingfeng Huang, Qianqian Liu, Peipei Gong, Shiqiang Hou, Hui Zhu, Zhongzheng Jia, Dandan Shen, Changlai Zhu, Rui Jiang, Junlong Sun, Junzhong Yao, Zhongyu Tang, Xiang Ji, Jinlong Shi, Rongqin Huang, Wei Shi

Small· Volume 14· Issue 42

Publisher page Open full text

Source abstract

Abstract

In article number 1801905, Jinlong Shi, Rongqin Huang, Wei Shi, and co-workers describe a novel drug-loaded system, OPPD, which uses PEG and OMCN linked to the Pep22 polypeptide targeting the low-density lipoprotein receptor, that can effectively cross the blood-brain barrier and target glioma cells, exerting an outstanding therapeutic efficacy via both the near-infrared photothermal and chemotherapeutic effects of the loaded DOX. The collective findings support the utility of OPPD, a promising drug-delivery vehicle, for future clinical application in glioma therapy.

Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer Research and Treatments · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Jiangsu Clinical Medicine Centre of Tissue Engineering and Nerve Injury Repair Department of Neurosurgery Affiliated Hospital of Nantong University Nantong 226001 China

Department of Pharmaceutics School of Pharmacy Key Laboratory of Smart Drug Delivery Ministry of Education Fudan University Shanghai 201203 China

Center for Advanced Low‐Dimension Materials Donghua University Shanghai 201620 China

Department of Pathology Clinical Bio‐Bank Affiliated Hospital of Nantong University Nantong 226001 China

Research Centre of Clinical Medicine Affiliated Hospital of Nantong University Nantong 226001 China

Medical Image Centre Affiliated Hospital of Nantong University Nantong 226001 China

Jiangsu Key Laboratory of Neuroregeneration Nantong University Nantong 226001 China

References

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