journal article·2024-02Open access

A Mechanism Underpinning the Bioenergetic Metabolism‐Regulating Function of Gold Nanocatalysts (Small 8/2024)

Zixin Wang, Alexandre Henriques, Laura Rouvière, Noëlle Callizot, Lin Tan, Michael T. Hotchkin, Rodrigue Rossignol, Mark G. Mortenson, Adam R. Dorfman, Karen S. Ho, Hui Wang

Small· Volume 20· Issue 8

Abstract

Au Nanocrystals In article number 2304082, Karen S. Ho, Hui Wang, and co-workers described a mechanism of action for gold nanocrystals comprising CNM-Au8, a novel investigational drug in clinical development for the treatment of multiple neurodegenerative diseases. The electrochemical synthesis of CNM-Au8 results in clean-surfaced nanocrystals with catalytic activity to efficiently convert the key energy metabolite NADH to NAD+, resulting in striking neuroprotective properties.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Cancer Research and Treatment

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry and Biochemistry University of South Carolina Columbia SC 29208 USA

Neuro‐Sys 410 D60 Gardanne 13120 France

Clene Nanomedicine, Inc. Salt Lake City UT 84117 USA

Cellomet CARF Center University of Bordeaux 146 rue Léo Saignat Bordeaux 33000 France

Clene Nanomedicine, Inc. North East MD 21901 USA

References

Reference metadata was not supplied for this record.