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journal article·2024-12Open access

PAD4 Inhibitor‐Loaded Layered Double Hydroxide Nanosheets as a Multifunctional Nanoplatform for Photodynamic Therapy‐Mediated Tumor Metastasis Treatment (Small 50/2024)

Rong Chen, Tingting Hu, Yu Lu, Shuqing Yang, Min Zhang, Chaoliang Tan, Ruizheng Liang, Yuji Wang

Small· Volume 20· Issue 50
Publisher pageOpen full text
Source abstract

Abstract

Tumor Metastasis Treatment PAD4 inhibitor-loaded DR-CoMo-LDH nanosheets can generate ROS under 1270 nm laser irradiation, effectively killing tumor cells and inducing immunogenic cell death. Additionally, laser irradiation facilitates the release of PAD4 inhibitor, which suppresses NETs formation, thereby exerting a synergistic PDT/immunotherapy effect. More in article number 2404211, Chaoliang Tan, Ruizheng Liang, Yuji Wang, and co-workers.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Medicinal Chemistry College of Pharmaceutical Sciences of Capital Medical University Beijing 100069 P. R. China

Department Electrical and Electronic Engineering The University of Hong Kong Pokfulam Road Hong Kong SAR 999077 P. R. China

State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China

Department of Nephrology Affiliated Beijing Chaoyang Hospital of Capital Medical University Beijing 100020 P. R. China

Department Electrical Engineering City University of Hong Kong 83 Tat Chee Ave, Kowloon Tong Hong Kong SAR 999077 P. R. China

Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou 324000 P. R. China

Beijing Area Major Laboratory of Peptide and Small Molecular Drugs Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China Beijing Laboratory of Biomedical Materials Laboratory for Clinical Medicine Beijing Laboratory of Oral Health Capital Medical University Beijing 100069 P. R. China

References

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