Drug Delivery: Vaults Engineered for Hydrophobic Drug Delivery (Small 10/2011)

The frontispiece of the Full Papers section (right) shows a single-particle electron microscope tomography reconstruction, which reveals that a fully assembled drug-loaded nanodisk (red) can be packaged into the vault lumen (green) as a viable method for vault-mediated drug delivery. The electron micrograph in the background shows negatively stained vaults containing nanodisks. For more information, please read the Full Paper “Vaults Engineered for Hydrophobic Drug Delivery” by L. H. Rome and co-workers, beginning on page 1431.