Facile synthesis of 2-(2-chloroquinolin-3-Yl)-2-((trimethylsilyl)oxy) acetonitriles utilizing TMSCN-ZnI2/DCM
Source abstract
Abstract
A facile synthesis of silicon-containing trimethylsilylated quinolines, 20 from 2-chloro-quinoline-3-carboxaldehyde, 19 are accounted for utilizing trimethylsilyl cyanide (TMSCN) as a reagent, zinc iodide (ZnI2) as a catalyst in dichloromethane (DCM) at room temperature with excellent yields. Further, silylated quinolines, 20 were converted into quinolinyl acetonitriles, 21 in the presence of dilute hydrochloric acid at room temperature in significant yields. Trimethylsilyl cyanide (TMSCN) reacts with aldehyde functional group to form protected silicon ethers as shown in 1HNMR, 13CNMR, and Mass spectral analysis.
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Research context
OpenAlex topics: Asymmetric Synthesis and Catalysis · Synthetic Organic Chemistry Methods · Synthesis of heterocyclic compounds
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References (35)
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