Comparative Modeling Approaches in the Development and Evaluation of Silica Nanoparticles as 5-Fluorouracil Carriers using PLS, DoE and GBR
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OpenAlex topics: Colorectal Cancer Treatments and Studies · Drug Solubulity and Delivery Systems · Mesoporous Materials and Catalysis
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References (34)
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1. Maver U, Godec A, Bele M et al (2007) Novel hybrid silica xerogels for stabilization and controlled release of drug. Int J Pharm 330:164–174. https://doi.org/10.1016/J.IJPHARM.2006.09.02410.1016/J.IJPHARM.2006.09.024 ↗
2. Barbé C, Bartlett J, Kong L et al (2004) Silica particles: a novel drug-delivery system. Adv Mater 16:1959–1966. https://doi.org/10.1002/ADMA.20040077110.1002/ADMA.200400771 ↗
3. Kortesuo P, Ahola M, Kangas M et al (2001) In vitro release of dexmedetomidine from silica xerogel monoliths: effect of sol-gel synthesis parameters. Int J Pharm 221:107–114. https://doi.org/10.1016/S0378-5173(01)00656-110.1016/S0378-5173(01)00656-1 ↗
4. Milea CA, Bogatu C, Duta A (2011) The influence of parameters in silica sol- gel process. Bull Transilv Univ Brasov Ser I-Eng Sci 4:59–66
5. Giovannini G, Kunc F, Piras CC et al (2017) Stabilizing silica nanoparticles in hydrogels: impact on storage and polydispersity. RSC Adv 7:19924–19933. https://doi.org/10.1039/C7RA02427D10.1039/C7RA02427D ↗
6. Steven CR, Busby GA, Mather C et al (2014) Bioinspired silica as drug delivery systems and their biocompatibility. J Mater Chem B 2:5028–5042. https://doi.org/10.1039/C4TB00510D10.1039/C4TB00510D ↗
7. Prokopowicz M (2009) Correlation between physicochemical properties of doxorubicin-loaded silica/polydimethylsiloxane xerogel and in vitro release of drug. Acta Biomater 5:193–207. https://doi.org/10.1016/J.ACTBIO.2008.07.02710.1016/J.ACTBIO.2008.07.027 ↗
8. Bitar A, Ahmad NM, Fessi H, Elaissari A (2012) Silica-based nanoparticles for biomedical applications. Drug Discov Today 17:1147–1154. https://doi.org/10.1016/J.DRUDIS.2012.06.01410.1016/J.DRUDIS.2012.06.014 ↗
9. Jung HS, Moon DS, Lee JK (2012) Quantitative analysis and efficient surface modification of silica nanoparticles. J Nanomater 2012:593471. https://doi.org/10.1155/2012/59347110.1155/2012/593471 ↗
10. Moodley T, Singh M (2019) Polymeric mesoporous silica nanoparticles for enhanced delivery of 5-fluorouracil in vitro. Pharmaceutics 11:11:288. https://doi.org/10.3390/PHARMACEUTICS1106028810.3390/PHARMACEUTICS11060288 ↗
11. Glavas-Dodov M, Steffansen B, Crcarevska MS et al (2013) Wheat germ agglutinin-functionalised crosslinked polyelectrolyte microparticles for local colon delivery of 5-FU: in vitro efficacy and in vivo gastrointestinal distribution. J Microencapsul 30:643–656. https://doi.org/10.3109/02652048.2013.77009910.3109/02652048.2013.770099 ↗
12. Rejinold NS, Muthunarayanan M, Chennazhi KP et al (2011) 5-fluorouracil loaded fibrinogen nanoparticles for cancer drug delivery applications. Int J Biol Macromol 48:98–105. https://doi.org/10.1016/J.IJBIOMAC.2010.10.00310.1016/J.IJBIOMAC.2010.10.003 ↗
13. Ln K, Jagadeeshan S, Nair SA, Kumar GV (2011) Biological evaluation of 5-fluorouracil nanoparticles for cancer chemotherapy and its dependence on the carrier, PLGA. Int J Nanomedicine 6:1685–1697. https://doi.org/10.2147/IJN.S2016510.2147/IJN.S20165 ↗
14. Al Sabbagh C, Agapova E, Boudy V, Mignet N (2021) Stability of calcium levofolinate, 5-fluorouracil and oxaliplatin (FOLFOX) mixture. J Oncol Pharm Pract 28:1303–1314. https://doi.org/10.1177/1078155221102080810.1177/10781552211020808 ↗
15. Mainuddin KA, Ratnesh RK et al (2024) Physical characterization and bioavailability assessment of 5-fluorouracil-based nanostructured lipid carrier (NLC): In vitro drug release, Hemolysis, and permeability modulation. Med Oncol 41:1–16. https://doi.org/10.1007/S12032-024-02319-3/TABLES/210.1007/S12032-024-02319-3/TABLES/2 ↗
16. Bozkir A, Saka OM (2005) Formulation and investigation of 5-FU nanoparticles with factorial design-based studies. Farm 60:840–846. https://doi.org/10.1016/J.FARMAC.2005.06.01610.1016/J.FARMAC.2005.06.016 ↗
17. de Lima JM, Castellano LRC, Bonan PRF et al (2021) Chitosan/PCL nanoparticles can improve anti-neoplastic activity of 5-fluorouracil in head and neck cancer through autophagy activation. Int J Biochem Cell Biol. https://doi.org/10.1016/J.BIOCEL.2021.10596410.1016/J.BIOCEL.2021.105964 ↗
18. Hong J, Feng Z (2021) Synergic fabrication of combination therapy of Irinotecan and 5-Fluorouracil encapsulated polymeric nanoparticles for the treatment of gastric cancer therapy. Process Biochem 106:191–198. https://doi.org/10.1016/J.PROCBIO.2021.04.00810.1016/J.PROCBIO.2021.04.008 ↗
19. Samy M, Abdallah HM, Awad HM, Ayoub MMH (2023) Preparation, characterization and in vitro biological activity of 5-Fluorouracil loaded onto poly (D, L-lactic-co-glycolic acid) nanoparticles. Polym Bull 80:6197–6219. https://doi.org/10.1007/S00289-022-04308-W10.1007/S00289-022-04308-W ↗
20. Park SK, Do KK, Kim HT (2002) Preparation of silica nanoparticles: determination of the optimal synthesis conditions for small and uniform particles. Colloids Surf A Physicochem Eng Asp 197:7–17. https://doi.org/10.1016/S0927-7757(01)00683-510.1016/S0927-7757(01)00683-5 ↗
21. Yusof FAM, Tajudin Z, Ong SK, Hashim AS (2019) Optimization of early stage hydrolysis of silica sol-gel/kenaf using response surface methodology. Mater Today Proc 19:1663–1672. https://doi.org/10.1016/J.MATPR.2019.11.19510.1016/J.MATPR.2019.11.195 ↗
22. Jaramillo N, Paucar C, Fernández A et al (2018) Microemulsion assisted sol-gel method as approach to load a model anticancer drug inside silica nanoparticles for controlled release applications. Colloid Interface Sci Commun 24:13–17. https://doi.org/10.1016/J.COLCOM.2018.03.00210.1016/J.COLCOM.2018.03.002 ↗
23. Wang S, Walker-Gibbons R, Watkins B et al (2024) A charge-dependent long-ranged force drives tailored assembly of matter in solution. Nat Nanotechnol 19:485–493. https://doi.org/10.1038/s41565-024-01621-510.1038/s41565-024-01621-5 ↗
24. Wheeler G (2005) Alkoxysilanes and the Consolidation of Stone. Getty Conservation Institute, Los Angeles
25. Balköse D (1990) Effect of preparation pH on properties of silica gel. J Chem Technol Biotechnol 49:165–171. https://doi.org/10.1002/JCTB.28049020710.1002/JCTB.280490207 ↗
26. Owens GJ, Singh RK, Foroutan F et al (2016) Sol–gel based materials for biomedical applications. Prog Mater Sci 77:1–79. https://doi.org/10.1016/J.PMATSCI.2015.12.00110.1016/J.PMATSCI.2015.12.001 ↗
27. Szegedi A, Popova M, Goshev I, Mihály J (2011) Effect of amine functionalization of spherical MCM-41 and SBA-15 on controlled drug release. J Solid State Chem 184:1201–1207. https://doi.org/10.1016/J.JSSC.2011.03.00510.1016/J.JSSC.2011.03.005 ↗
28. Kardys AY, Bharali DJ, Mousa SA (2013) Amino-functionalized silica nanoparticles. In vitro evaluation for targeted delivery and therapy of pancreatic cancer. J Nanotechnol 2013:768724. https://doi.org/10.1155/2013/76872410.1155/2013/768724 ↗
29. Digigow RG, Dechézelles JF, Dietsch H et al (2014) Preparation and characterization of functional silica hybrid magnetic nanoparticles. J Magn Magn Mater 362:72–79. https://doi.org/10.1016/J.JMMM.2014.03.02610.1016/J.JMMM.2014.03.026 ↗
30. Djurdjic B, Makreski P, Boev I et al (2024) ORMOSIL nanoparticles as drug delivery carriers for oxaliplatin: formulation development and characterization. Chem Pap 78:6499–6512. https://doi.org/10.1007/S11696-024-03550-Y/FIGURES/810.1007/S11696-024-03550-Y/FIGURES/8 ↗
31. Petrovska-Jovanovska V, Geskovski N, Crcarevska MS et al (2015) Formulation and characterization of ORMOSIL particles loaded with budesonide for local colonic delivery. Int J Pharm 484:75–84. https://doi.org/10.1016/J.IJPHARM.2015.02.04410.1016/J.IJPHARM.2015.02.044 ↗
32. Wu Z, Xiang H, Kim T et al (2006) Surface properties of submicrometer silica spheres modified with aminopropyltriethoxysilane and phenyltriethoxysilane. J Colloid Interface Sci 304:119–124. https://doi.org/10.1016/J.JCIS.2006.08.05510.1016/J.JCIS.2006.08.055 ↗
33. Singh R, Lillard JW (2009) Nanoparticle-based targeted drug delivery. Exp Mol Pathol 86:215–223. https://doi.org/10.1016/J.YEXMP.2008.12.00410.1016/J.YEXMP.2008.12.004 ↗
34. Braun A, Couteau O, Franks K et al (2011) Validation of dynamic light scattering and centrifugal liquid sedimentation methods for nanoparticle characterisation. Adv Powder Technol 22:766–770. https://doi.org/10.1016/J.APT.2010.11.00110.1016/J.APT.2010.11.001 ↗