Stain Etched Nanostructured Porous Silicon: The Role of Morphology on Antibacterial Drug Loading and Release
Source abstract
Abstract
In this work, nanostructured porous silicon (pSi) prepared by a metal-assisted stain etched route is investigated for its ability to act as a carrier for sustained delivery of the antibacterial drug triclosan. The morphology, analyzed by transmission electron microscopy, reveals a rather different microstructure than traditional anodized porous silicon; as a consequence, such morphology manifests a different loaded drug crystallinity, triclosan release behavior, and associated antibacterial activity versus Staphococcus aureus relative to high porosity anodized porous silicon. In addition to electron microscopies and antibacterial disk diffusion assays, a combination of x-ray diffraction, thermogravimetric analyses, and UV/Vis spectrophotometric analysis of triclosan release are employed to carry out the above investigations.
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Research context
OpenAlex topics: Silicon Nanostructures and Photoluminescence · Nanowire Synthesis and Applications · Quantum Dots Synthesis And Properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (26)
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1. Chan S, Fauchet PM, Li Y, Rothberg LJ, Miller BL (2000) Porous silicon microcavities for biosensing applications. Phys Status Solidi A 182:541–54610.1002/1521-396X(200011)182:1<541::AID-PSSA541>3.0.CO;2-# ↗
2. Orosco MM, Pacholski C, Sailor MJ (2009) Real-time monitoring of enzyme activity in a mesoporous silicon double layer. Nat Nanotechnol 4:255–25810.1038/nnano.2009.11 ↗
3. Bonanno L, Segal E (2011) Nanostructured porous silicon-polymer-based hybrids: from biosensing to drug delivery. Nanomedicine 6:1755–177010.2217/nnm.11.153 ↗
4. Rodriguez GA, Lawrie JL, Weiss SM (2014) Nanoporous silicon biosensors for DNA sensing. In: Santos H (ed) Porous silicon for biomedical applications. Woodhead Publishing, Cambridge, pp 304–33310.1533/9780857097156.2.304 ↗
5. Coffer JL, Montchamp JL, Aimone JB, Weis RP (2003) Routes to calcified porous silicon: implications for drug delivery and biosensing. Phys Status Solidi A 197:336–33910.1002/pssa.200306520 ↗
6. Salonen J, Kaukonen AM, Hirvonen J, Lehto V (2008) Mesoporous silicon in drug delivery applications. J Pharm Sci 97:632–65110.1002/jps.20999 ↗
7. Anglin EJ, Cheng L, Freeman WR, Sailor M J (2008) Porous silicon in drug delivery devices and materials. Adv Drug Deliv Rev 60:1266–127710.1016/j.addr.2008.03.017 ↗
8. Lehto V-P, Riikonen J (2014) Drug loading and characterization of porous silicon materials. In: Santos H (ed) Porous silicon for biomedical applications. Woodhead Publishing, Cambridge, pp 337–35510.1533/9780857097156.3.337 ↗
9. Bowditch AP, Waters K, Gale H, Rice P, Scott EAM, Canham LT, Reeves CL, Loni A, Cox TI (1999) In vivo assessment of tissue compatibility and calcification of bulk and porous silicon. Mater Res Soc Symp Proc 536:149–15410.1557/PROC-536-149 ↗
10. Canham LT (2014) Pore volume (porosity) in porous silicon. In: Canham LT (ed) Handbook of porous silicon. Springer International, Switzerland, pp 135–14210.1007/978-3-319-05744-6_13 ↗
11. Buriak JM (2002) Organometallic chemistry on silicon and germanium surfaces. Chem Rev 102:1271–130810.1021/cr000064s ↗
12. Loni A (2014) Milling of porous silicon microparticles. In: Canham LT (ed) Handbook of porous silicon. Springer International, Switzerland, pp 695–70510.1007/978-3-319-05744-6_71 ↗
13. Joo J, Cruz JF, Vijayakumar S, Grondek J, Sailor MJ (2014) Photoluminescent porous Si/SiO2 core/shell nanoparticles prepared by borate oxidation. Adv Funct Mater 24:5688–569410.1002/adfm.201400587 ↗
14. Tasciotti E, Liu X, Bhavane R, Plant K, Leonard AD, Price BK, Cheng MM, Decuzzi P, Tour J M, Robertson F, Ferrari M (2008) Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nat Nanotechnol 3:151–15710.1038/nnano.2008.34 ↗
15. Li X, Coffer JL, Chen Y, Pinizzotto RF, Newey J, Canham LT (1998) Transition metal complex-doped hydroxyapatite layers on porous silicon. J Am Chem Soc 120:11706–1170910.1021/ja9823666 ↗
16. Gu L, Park J-H, Duong K H, Ruoslahti E, Sailor M J (2010) Magnetic luminescent porous silicon microparticles for localized delivery of molecular drug payloads. Small 6:2546–255210.1002/smll.201000841 ↗
17. Tzur-Balter A, Rubinski A, Segal E (2013) Designing porous silicon-based microparticles as carriers for controlled delivery of mitoxantrone dihydrochloride. J Mater Res 28:231–23910.1557/jmr.2012.299 ↗
18. Wang M, Coffer JL, Dorraj K, Hartman PS, Loni A, Canham LT (2010) Sustained antibacterial activity from triclosan-loaded nanostructured mesoporous silicon. Mol Pharm 7:2232–223910.1021/mp100227m ↗
19. Tang L, Saharay A, Fleischer W, Hartman P, Loni A, Canham LT, Coffer JL (2013) Sustained antifungal activity from a ketoconazole-loaded nanostructured mesoporous silicon platform. Silicon 5:213–21710.1007/s12633-013-9143-5 ↗
20. Salonen J, Laitinen L, Kaukonen AM, Tuuraa J, Björkqvista M, Heikkiläa T, Vähä-Heikkiläa K, Hirvonen J, Lehto V-P (2005) Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs. J Control Release 108:362– 37410.1016/j.jconrel.2005.08.017 ↗
21. Gu L, Ruff LE, Qin Z, Corr M, Hedrick SM, Sailor MJ (2012) Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody. Adv Mater 24:3981–398710.1002/adma.201200776 ↗
22. Kilpeläinen M, Riikonen J, Vlasova MA, Huotari A, Lehto V-P, Salonen J, Herzig K H, Järvinen K. (2009) In vivo delivery of a peptide, ghrelin antagonist, with mesoporous silicon microparticles. J Control Release 137:166–17010.1016/j.jconrel.2009.03.017 ↗
23. Sailor M (2012) Porous silicon in practice. Wiley-VCH, Weinheim, pp 48–51
24. Loni A, Barwick D, Batchelor L, Tunbridge J, Han Y, Li Z, Canham LT (2011). Electrochem Solid-State Lett 14:K25–K2710.1149/1.3548513 ↗
25. Cullis AG, Canham LT (1991) Visible light emission due to quantum size effects in highly porous crystalline silicon. Nature 353:335–33810.1038/353335a0 ↗
26. Canham LT, Cullis AG, Pickering C, Dosser OD, Cox TI, Lynch TP (1994) Luminescent silicon aerocrystal networks prepared by anodisation and supercritical drying. Nature 368:133– 13510.1038/368133a0 ↗