Dopamine detection using a patch-clamp system on a planar microeletrode array electrodeposited by polypyrrole/graphene nanocomposites
Source abstract
Abstract
To achieve a dopamine (DA) response with high sensitivity and high signal-to-noise ratio (S/N) with a patch-clamp system, polypyrrole/graphene (PPy/GR) nanocomposites were steadily electrodeposited by an electrochemical method on a planar microelectrode array (pMEA) fabricated by a standard micromachining process. The electrodeposition process was carried out by chronopotentimetry measurement scanning from 0.1 to 0.8 C/cm2 at the current of 2 mA; 0.5 C/cm2 was found to be optimal. The pMEA modified by PPy/GR at the 0.5 C/cm2 exhibits remarkable properties; for instance, the standard deviation (SD) decreases from 8.4614×10−11 to 5.62×10−11 A, reduced by 33.52%, and the sensitivity increases from 2566.88 to 76114.65 μAmMcm−2, 29.65 times higher than the bare Pt (platinum). A good linear relationship between the current and DA concentration in the range of 0.30 to 61.71 μm was obtained, with a correlation coefficient of 0.997. The sensor is meaningful for neuroscience research and the treatment of neurological diseases.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Electrochemical sensors and biosensors · Conducting polymers and applications · Electrochemical Analysis and Applications
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