Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications
Source abstract
Abstract
Biomedical applications of porous calcium carbonate (CaCO3) microspheres have been mainly restricted by their aqueous instability and low remineralization rate. To overcome these obstacles, a novel symmetry-breaking assembled porous calcite microsphere (PCMS) was constructed in an ethanol/water mixed system using a two-step vapor-diffusion/aging crystallization strategy. In contrast to the conventional additive-induced crystallization method, the present strategy was performed under mild conditions and was free from any foreign additives, thus avoiding the potential contamination of the final product. Meanwhile, the prepared PCMSs were characterized by their highly uniform spherical morphology and large open pores, which are favorable for large protein delivery. An antimicrobial study of immunoglobulin Y (IgY)-loaded PCMSs revealed excellent antimicrobial activity against Streptococcus mutans. More importantly, they showed surprisingly rapid transformation to bone minerals in physiological medium. Evaluation of the in vitro efficacy of PCMSs in dentinal tubule occlusion demonstrated their powerful potential to serve as a catalyst in the repair of dental hard tissue. Therefore, the developed PCMSs show great promise as multifunctional biomaterials for dental treatment applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Calcium Carbonate Crystallization and Inhibition · Dental Erosion and Treatment
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (42)
Show source-provided references
1. Trushina DB, Bukreeva TV, Kovalchuk MV, et al. Ca CO3 vaterite microparticles for biomedical and personal care applications. Mater Sci Eng-C, 2014, 45: 644–65810.1016/j.msec.2014.04.050 ↗
2. Cury JA, Simões GS, Del Bel Cury AA, et al. Effect of a calcium carbonate- based dentifrice on in situ enamel remineralization. Caries Res, 2005, 39: 255–25710.1159/000084807 ↗
3. Elabbadi A, Jeckelmann N, Haefliger O, et al. Selective coprecipitation of polyphenols in bioactive/inorganic complexes. ACS Appl Mater Interfaces, 2011, 3: 2764–277110.1021/am2005515 ↗
4. Lu P, Arai K, Kuboyama N. Possibility of application of calcium carbonate in pulpotomy of rat molars. Pediatric Dental J, 2010, 20: 45–5610.1016/S0917-2394(10)70192-0 ↗
5. Pickles MJ, Evans M, Philpotts CJ, et al. In vitro efficacy of a whitening toothpaste containing calcium carbonate and perlite. Int Dental J, 2005, 55: 197–20210.1111/j.1875-595X.2005.tb00060.x ↗
6. Ueno Y, Futagawa H, Takagi Y, et al. Drug-incorporating calcium carbonate nanoparticles for a new delivery system. J Control Release, 2005, 103: 93–9810.1016/j.jconrel.2004.11.015 ↗
7. Wei W, Ma GH, Hu G, et al. Preparation of hierarchical hollow Ca CO3 particles and the application as anticancer drug carrier. J Am Chem Soc, 2008, 130: 15808–1581010.1021/ja8039585 ↗
8. Kim YY, Schenk AS, Ihli J, et al. A critical analysis of calcium carbonate mesocrystals. Nat Commun, 2014, 5: 434110.1038/ncomms5341 ↗
9. Yu JG, Guo H, Davis SA, et al. Fabrication of hollow inorganic microspheres by chemically induced self-transformation. Adv Funct Mater, 2006, 16: 2035–204110.1002/adfm.200600552 ↗
10. Lee K, Wagermaier W, Masic A, et al. Self-assembly of amorphous calcium carbonate microlens arrays. Nat Commun, 2012, 3: 72510.1038/ncomms1720 ↗
11. Wolf SE, Leiterer J, Pipich V, et al. Strong stabilization of amorphous calcium carbonate emulsion by ovalbumin: gaining insight into the mechanism of ‘polymer-induced liquid precursor’ processes. J Am Chem Soc, 2011, 133: 12642–1264910.1021/ja202622g ↗
12. Qi C, Zhu YJ, Lu BQ, et al. ATP-stabilized amorphous calcium carbonate nanospheres and their application in protein adsorption. Small, 2014, 10: 2047–205610.1002/smll.201302984 ↗
13. Hetherington NBJ, Kulak AN, Kim YY, et al. Porous single crystals of calcite from colloidal crystal templates: ACC is not required for nanoscale templating. Adv Funct Mater, 2011, 21: 948–95410.1002/adfm.201001366 ↗
14. Won YH, Jang HS, Chung DW, et al. Multifunctional calcium carbonate microparticles: synthesis and biological applications. J Mater Chem, 2010, 20: 7728–773310.1039/c0jm01231a ↗
15. Zhang J, Li Y, Xie H, et al. Calcium carbonate nanoplate assemblies with directed high-energy facets: additive-free synthesis, high drug loading, and sustainable releasing. ACS Appl Mater Interfaces, 2015, 7: 15686–1569110.1021/acsami.5b04819 ↗
16. Volodkin DV, Petrov AI, Prevot M, et al. Matrix polyelectrolytemicrocapsules: new system for macromolecule encapsulation. Langmuir, 2004, 20: 3398–340610.1021/la036177z ↗
17. Wang X, Kong R, Pan X, et al. Role of ovalbumin in the stabilization of metastable vaterite in calcium carbonate biomineralization. J Phys Chem B, 2009, 113: 8975–898210.1021/jp810281f ↗
18. Zhang Z, Gao D, Zhao H, et al. Biomimetic assembly of polypeptide- stabilized Ca CO3 nanoparticles. J Phys Chem B, 2006, 110: 8613–861810.1021/jp060838u ↗
19. Cölfen H, Antonietti M. Crystal design of calcium carbonate microparticles using double-hydrophilic block copolymers. Langmuir, 1998, 14: 582–58910.1021/la970765t ↗
20. Chen SF, Yu SH, Jiang J, et al. Polymorph discrimination of Ca CO3 mineral in an ethanol/water solution: formation of complex vaterite superstructures and aragonite rods. Chem Mater, 2006, 18: 115–12210.1021/cm0519028 ↗
21. de Leeuw NH, Parker SC. Surface structure and morphology of calcium carbonate polymorphs calcite, aragonite, and vaterite: an atomistic approach. J Phys Chem B, 1998, 102: 2914–292210.1021/jp973210f ↗
22. Montes-Hernandez G, Renard F, Findling N, et al. Formation of porous calcitemesocrystals from CO2–H2O–Ca(OH)2 slurry in the presence of common domestic drinks. Cryst Eng Comm, 2015, 17: 5725–573310.1039/C4CE01598C ↗
23. Wang J, Li D, Li T, et al. Gelatin tight-coated poly(lactide-co-glycolide) scaffold incorporating rh BMP-2 for bone tissue engineering. Materials, 2015, 8: 1009–102610.3390/ma8031009 ↗
24. Zhang N, Wang Y, Xu W, et al. Poly(lactide-co-glycolide)/hydroxyapatite porous scaffold withmicrochannels for bone regeneration. Polymers, 2016, 8: 21810.3390/polym8060218 ↗
25. Domingo C, Loste E, Gómez-Morales J, et al. Calcite precipitation by a high-pressure CO2 carbonation route. J Supercritical Fluids, 2006, 36: 202–21510.1016/j.supflu.2005.06.006 ↗
26. Lee HS, Ha TH, Kim K. Fabrication of unusually stable amorphous calcium carbonate in an ethanolmedium. Mater Chem Phys, 2005, 93: 376–38210.1016/j.matchemphys.2005.03.037 ↗
27. Saleem IY, Vordermeier M, Barralet JE, et al. Improving peptidebased assays to differentiate between vaccination and mycobacterium bovis infection in cattle using nanoparticle carriers for adsorbed antigens. J Control Release, 2005, 102: 551–56110.1016/j.jconrel.2004.10.034 ↗
28. Ikoma T, Tonegawa T, Watanaba H, et al. Drug-supported microparticles of calcium carbonate nanocrystals and its covering with hydroxyapatite. J Nanosci Nanotech, 2007, 7: 822–82710.1166/jnn.2007.523 ↗
29. Cai WY, Feng LD, Liu SH, et al. Hemoglobin-Cd Te-Ca CO3 @polyelectrolytes 3D architecture: fabrication, characterization, and application in biosensing. Adv Funct Mater, 2008, 18: 3127–313610.1002/adfm.200800531 ↗
30. Sand KK, Rodriguez-Blanco JD, Makovicky E, et al. Crystallization of Ca CO3 in water–alcoholmixtures: spherulitic growth, polymorph stabilization, and morphology change. Cryst Growth Des, 2012, 12: 842–85310.1021/cg2012342 ↗
31. Wang T, Cölfen H, Antonietti M. Nonclassical crystallization: mesocrystals and morphology change of Ca CO3 crystals in the presence of a polyelectrolyte additive. J Am Chem Soc, 2005, 127: 3246–324710.1021/ja045331g ↗
32. Smith DJ, King WF, Godiska R. Passive transfer of immunoglobulin Y antibody to Streptococcus mutans glucan binding protein B can confer protection against experimental dental caries. Infection Immun, 2001, 69: 3135–314210.1128/IAI.69.5.3135-3142.2001 ↗
33. Nilsson E, Kollberg H, Johannesson M, et al. More than 10 years' continuous oral treatment with specific immunoglobulin Y for the prevention of Pseudomonas aeruginosa infections: a case report. J Medicinal Food, 2007, 10: 375–37810.1089/jmf.2006.214 ↗
34. Klein MI, Hwang G, Santos PHS, et al. Streptococcus mutans-derived extracellular matrix in cariogenic oral biofilms. Front Cell Infect Microbiol, 2015, 5: 1010.3389/fcimb.2015.00010 ↗
35. Kim S, Park CB. Mussel-inspired transformation of Ca CO3 to bone minerals. Biomaterials, 2010, 31: 6628–663410.1016/j.biomaterials.2010.05.004 ↗
36. de La Pierre M, Carteret C, Maschio L, et al. The Raman spectrum of Ca CO3 polymorphs calcite and aragonite: a combined experimental and computational study. J Chem Phys, 2014, 140: 16450910.1063/1.4871900 ↗
37. Yamini D, Devanand Venkatasubbu G, Kumar J, et al. Raman scattering studies on PEG functionalized hydroxyapatite nanoparticles. Spectrochimica Acta Part A-Mol Biomolecular Spectroscopy, 2014, 117: 299–30310.1016/j.saa.2013.07.064 ↗
38. Chiang YC, Lin HP, Chang HH, et al. A mesoporous silica biomaterial for dental biomimetic crystallization. ACS Nano, 2014, 8: 12502–1251310.1021/nn5053487 ↗
39. Absi EG, Addy M, Adams D. Dentine hypersensitivity. A study of the patency of dentinal tubules in sensitive and non-sensitive cervical dentine. J Clin Periodontol, 1987, 14: 280–284
40. Oh DX, Prajatelistia E, Ju SW, et al. A rapid, efficient, and facile solution for dental hypersensitivity: the tannin–iron complex. Sci Rep, 2015, 5: 1088410.1038/srep10884 ↗
41. Tsai WS, Placa SJ, Panagakos PS. Clinical evaluation of an in-office desensitizing paste containing 8% arginine and calcium carbonate for relief of dentin hypersensitivity prior to dental prophylaxis. Am J Dent, 2012, 25: 165-170
42. Suge T, Ishikawa K, Kawasaki A, et al. Duration of dentinal tubule occlusion formed by calcium phosphate precipitation method: in vitro evaluation using synthetic saliva. J Dental Res, 1995, 74: 1709–171410.1177/00220345950740101301 ↗