Tough and fatigue-resistant anisotropic hydrogels via fiber reinforcement and magnetic field induction
Source abstract
Abstract
生物组织(如肌腱、软骨等)不仅具有优异的强度、模量和韧性, 而且具有长期稳定性, 可承受数百万次高应力循环而不断裂, 其疲劳阈 值超过1000 J m−2. 相比之下, 尽管合成水凝胶在强度、模量、韧性和 其他性能方面与天然软组织相当, 但这些增韧水凝胶仍然会在反复循 环载荷下遭受疲劳断裂, 其疲劳阈值通常低于100 J m−2. 在本工作中, 我们报道了一种简单的策略, 用于开发韧性和抗疲劳的各向异性水凝 胶, 其疲劳阈值超过常规水凝胶的100倍. 各向异性水凝胶通过两步工 艺合成, 包括磁场定向工艺形成优先排列的PDA-Fe3O4-CF纤维结构, 以及冷冻解冻-退火工艺处理, 优先排列纤维结构和高结晶度的协同作 用具有超高的强度和韧性、优异的摩擦学性能和非凡的抗疲劳性能. 各向异性水凝胶的抗拉强度、抗压强度和疲劳阈值分别高达11.82 ± 0.85 MPa、5.95 ±0.35 MPa和1845 J m−2, 显著高于大多数生物凝胶和 合成水凝胶. 因此, 本研究为制造性能优异的软材料提供了一种可行的 方法, 拓展了软质材料在承重材料(如人工软组织)、软机器人、柔性电 子等领域的应用.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Sensor and Energy Harvesting Materials · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (54)
Show source-provided references
1. Mredha MTI, Jeon I. Biomimetic anisotropic hydrogels: Advanced fabrication strategies, extraordinary functionalities, and broad applications. Prog Mater Sci, 2021, 124: 10087010.1016/j.pmatsci.2021.100870 ↗
2. Zhao Z, Wang Z, Li G, et al. Injectable microfluidic hydrogel microspheres for cell and drug delivery. Adv Funct Mater, 2021, 31: 210333910.1002/adfm.202103339 ↗
3. Ilami M, Bagheri H, Ahmed R, et al. Materials, actuators, and sensors for soft bioinspired robots. Adv Mater, 2021, 33: 200313910.1002/adma.202003139 ↗
4. Jiang L, Lu X. Functional hydrogel-based supercapacitors for wearable bioelectronic devices. Mater Chem Front, 2021, 5: 7479–749810.1039/D1QM00657F ↗
5. Gu Z, Huang K, Luo Y, et al. Double network hydrogel for tissue engineering. WIREs Nanomed Nanobiotechnol, 2018, 10: e152010.1002/wnan.1520 ↗
6. Zhao H, Liu M, Zhang Y, et al. Nanocomposite hydrogels for tissue engineering applications. Nanoscale, 2020, 12: 14976–1499510.1039/D0NR03785K ↗
7. Beckett LE, Lewis JT, Tonge TK, et al. Enhancement of the mechanical properties of hydrogels with continuous fibrous reinforcement. ACS BioMater Sci Eng, 2020, 6: 5453–547310.1021/acsbiomaterials.0c00911 ↗
8. Zhang G, Chen S, Peng Z, et al. Topologically enhanced dual-network hydrogels with rapid recovery for low-hysteresis, self-adhesive epidemic electronics. ACS Appl Mater Interfaces, 2021, 13: 12531–1254010.1021/acsami.1c00819 ↗
9. Zhao Z, Fang R, Rong Q, et al. Bioinspired nanocomposite hydrogels with highly ordered structures. Adv Mater, 2017, 29: 170304510.1002/adma.201703045 ↗
10. Choi S, Choi Y, Kim J. Anisotropic hybrid hydrogels with superior mechanical properties reminiscent of tendons or ligaments. Adv Funct Mater, 2019, 29: 190434210.1002/adfm.201904342 ↗
11. Yang F, Zhao J, Koshut WJ, et al. A synthetic hydrogel composite with the mechanical behavior and durability of cartilage. Adv Funct Mater, 2020, 30: 200345110.1002/adfm.202003451 ↗
12. Sun JY, Zhao X, Illeperuma WRK, et al. Highly stretchable and tough hydrogels. Nature, 2012, 489: 133–13610.1038/nature11409 ↗
13. Gong JP, Katsuyama Y, Kurokawa T, et al. Double-network hydrogels with extremely high mechanical strength. Adv Mater, 2003, 15: 1155115810.1002/adma.200304907 ↗
14. Qiao Z, Cao M, Michels K, et al. Design and fabrication of highly stretchable and tough hydrogels. Polym Rev, 2020, 60: 420–44110.1080/15583724.2019.1691590 ↗
15. Bai R, Yang Q, Tang J, et al. Fatigue fracture of tough hydrogels. Extreme Mech Lett, 2017, 15: 91–9610.1016/j.eml.2017.07.002 ↗
16. Lin S, Liu X, Liu J, et al. Anti-fatigue-fracture hydrogels. Sci Adv, 2019, 5: eaau852810.1126/sciadv.aau8528 ↗
17. Bai R, Yang J, Morelle XP, et al. Fatigue fracture of self-recovery hydrogels. ACS Macro Lett, 2018, 7: 312–31710.1021/acsmacrolett.8b00045 ↗
18. Zhang W, Liu X, Wang J, et al. Fatigue of double-network hydrogels. Eng Fract Mech, 2018, 187: 74–9310.1016/j.engfracmech.2017.10.018 ↗
19. Bircher K, Zündel M, Pensalfini M, et al. Tear resistance of soft collagenous tissues. Nat Commun, 2019, 10: 79210.1038/s41467-019-08723-y ↗
20. Taylor D, O’Mara N, Ryan E, et al. The fracture toughness of soft tissues. J Mech Behav BioMed Mater, 2012, 6: 139–14710.1016/j.jmbbm.2011.09.018 ↗
21. Liang X, Chen G, Lin S, et al. Anisotropically fatigue-resistant hydrogels. Adv Mater, 2021, 33: 210201110.1002/adma.202102011 ↗
22. Lin S, Liu J, Liu X, et al. Muscle-like fatigue-resistant hydrogels by mechanical training. Proc Natl Acad Sci USA, 2019, 116: 10244–1024910.1073/pnas.1903019116 ↗
23. Hu D, Cui Y, Mo K, et al. Ultrahigh strength nanocomposite hydrogels designed by locking oriented tunicate cellulose nanocrystals in polymeric networks. Compos Part B-Eng, 2020, 197: 10811810.1016/j.compositesb.2020.108118 ↗
24. Chau M, De France KJ, Kopera B, et al. Composite hydrogels with tunable anisotropic morphologies and mechanical properties. Chem Mater, 2016, 28: 3406–341510.1021/acs.chemmater.6b00792 ↗
25. Hua M, Wu S, Ma Y, et al. Strong tough hydrogels via the synergy of freeze-casting and salting out. Nature, 2021, 590: 594–59910.1038/s41586-021-03212-z ↗
26. Liu K, Han L, Tang P, et al. An anisotropic hydrogel based on mussel-inspired conductive ferrofluid composed of electromagnetic nanohybrids. Nano Lett, 2019, 19: 8343–835610.1021/acs.nanolett.9b00363 ↗
27. Liu M, Ishida Y, Ebina Y, et al. An anisotropic hydrogel with electrostatic repulsion between cofacially aligned nanosheets. Nature, 2015, 517: 68–7210.1038/nature14060 ↗
28. Lu Q, Bai S, Ding Z, et al. Hydrogel assembly with hierarchical alignment by balancing electrostatic forces. Adv Mater Inter, 2016, 3: 150068710.1002/admi.201500687 ↗
29. Shi W, Huang J, Fang R, et al. Imparting functionality to the hydrogel by magnetic-field-induced nano-assembly and macro-response. ACS Appl Mater Interfaces, 2020, 12: 5177–519410.1021/acsami.9b16770 ↗
30. Hua M, He X. Soft-fiber-reinforced tough and fatigue resistant hydrogels. Matter, 2021, 4: 1755–175710.1016/j.matt.2021.05.006 ↗
31. Ni J, Lin S, Qin Z, et al. Strong fatigue-resistant nanofibrous hydrogels inspired by lobster underbelly. Matter, 2021, 4: 1919–193410.1016/j.matt.2021.03.023 ↗
32. Yang H, Ji M, Yang M, et al. Fabricating hydrogels to mimic biological tissues of complex shapes and high fatigue resistance. Matter, 2021, 4: 1935–194610.1016/j.matt.2021.03.011 ↗
33. Li X, Cui K, Kurokawa T, et al. Effect of mesoscale phase contrast on fatigue-delaying behavior of self-healing hydrogels. Sci Adv, 2021, 7: eabe821010.1126/sciadv.abe8210 ↗
34. Rong M, Liu H, Scaraggi M, et al. High lubricity meets load capacity: Cartilage mimicking bilayer structure by brushing up stiff hydrogels from subsurface. Adv Funct Mater, 2020, 30: 200406210.1002/adfm.202004062 ↗
35. Chen Q, Zhang X, Chen K, et al. Anisotropic hydrogels with enhanced mechanical and tribological performance by magnetically oriented nanohybrids. Chem Eng J, 2022, 430: 13303610.1016/j.cej.2021.133036 ↗
36. Frank E, Steudle LM, Ingildeev D, et al. Carbon fibers: Precursor systems, processing, structure, and properties. Angew Chem Int Ed, 2014, 53: 5262–529810.1002/anie.201306129 ↗
37. Luo H, Xiong G, Yang Z, et al. Preparation of three-dimensional braided carbon fiber-reinforced PEEK composites for potential load-bearing bone fixations. Part I. Mechanical properties and cyto-compatibility. J Mech Behav BioMed Mater, 2014, 29: 103–11310.1016/j.jmbbm.2013.09.003 ↗
38. Gupta AK, Gupta M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials, 2005, 26: 3995–402110.1016/j.biomaterials.2004.10.012 ↗
39. Liu Y, Ai K, Lu L. Polydopamine and its derivative materials: Synthesis and promising applications in energy, environmental, and biomedical fields. Chem Rev, 2014, 114: 5057–511510.1021/cr400407a ↗
40. Lee H, Dellatore SM, Miller WM, et al. Mussel-inspired surface chemistry for multifunctional coatings. Science, 2007, 318: 426–43010.1126/science.1147241 ↗
41. Fu Y, Han C, Ni Q. Effects of surface modification on the dispersion property of VGC. Chin J Chem, 2009, 27: 1110–111610.1002/cjoc.200990185 ↗
42. Holloway JL, Lowman AM, Palmese GR. The role of crystallization and phase separation in the formation of physically cross-linked PVA hydrogels. Soft Matter, 2013, 9: 826–83310.1039/C2SM26763B ↗
43. Bodugoz-Senturk H, Choi J, Oral E, et al. The effect of polyethylene glycol on the stability of pores in polyvinyl alcohol hydrogels during annealing. Biomaterials, 2008, 29: 141–14910.1016/j.biomaterials.2007.09.015 ↗
44. Bodugoz-Senturk H, Macias CE, Kung JH, et al. Poly(vinyl alcohol)-acrylamide hydrogels as load-bearing cartilage substitute. Biomaterials, 2009, 30: 589–59610.1016/j.biomaterials.2008.10.010 ↗
45. Chen K, Chen G, Wei S, et al. Preparation and property of high strength and low friction PVA-HA/PAA composite hydrogel using annealing treatment. Mater Sci Eng-C, 2018, 91: 579–58810.1016/j.msec.2018.05.080 ↗
46. Gan S, Lin W, Zou Y, et al. Nano-hydroxyapatite enhanced double network hydrogels with excellent mechanical properties for potential application in cartilage repair. Carbohydrate Polyms, 2020, 229: 11552310.1016/j.carbpol.2019.115523 ↗
47. Yu Y, Zhu C, Liu Y, et al. Synthesis and characterization of N-maleyl chitosan-cross-linked poly(acrylamide)/montmorillonite nanocomposite hydrogels. Polym-Plasts Tech Eng, 2011, 50: 525–52910.1080/03602559.2010.543735 ↗
48. Bai R, Yang J, Morelle XP, et al. Flaw-insensitive hydrogels under static and cyclic loads. Macromol Rapid Commun, 2019, 40: 180088310.1002/marc.201800883 ↗
49. Yang W, Sherman VR, Gludovatz B, et al. On the tear resistance of skin. Nat Commun, 2015, 6: 664910.1038/ncomms7649 ↗
50. Gillies AR, Lieber RL. Structure and function of the skeletal muscle extracellular matrix. Muscle Nerve, 2011, 44: 318–33110.1002/mus.22094 ↗
51. Little CJ, Bawolin NK, Chen X. Mechanical properties of natural cartilage and tissue-engineered constructs. Tissue Eng Part B-Rev, 2011, 17: 213–22710.1089/ten.teb.2010.0572 ↗
52. Chen Y, Jiao C, Peng X, et al. Biomimetic anisotropic poly(vinyl alcohol) hydrogels with significantly enhanced mechanical properties by freezing-thawing under drawing. J Mater Chem B, 2019, 7: 3243–324910.1039/C9TB00372J ↗
53. Wang X, Fang J, Zhu W, et al. Bioinspired highly anisotropic, ultra-strong and stiff, and osteoconductive mineralized wood hydrogel composites for bone repair. Adv Funct Mater, 2021, 31: 201006810.1002/adfm.202010068 ↗
54. Sun Q, Ma S, Lin P, et al. Anisotropic hydrogels with high mechanical strength by stretching-induced oriented crystallization and drying. ACS Appl Polym Mater, 2020, 2: 2142–215010.1021/acsapm.0c00096 ↗