Multi-stimuli responsive hydrogels in bone tissue engineering: microenvironmental cues and biofunctional strategies
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OpenAlex topics: Hydrogels: synthesis, properties, applications · Bone Tissue Engineering Materials · Supramolecular Self-Assembly in Materials
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References (100+)
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1. Kim J, Lee CM, Moon SY, et al. Biomedical membrane of fish collagen/gellan gum containing bone graft materials. Materials, 2022, 15: 295410.3390/ma15082954 ↗
2. Liang B, Liang JM, Ding JN, et al. Dimethyloxaloylglycine-stimulated human bone marrow mesenchymal stem cell-derived exosomes enhance bone regeneration through angiogenesis by targeting the AKT/mTOR pathway. Stem Cell Res Ther, 2019, 10: 33510.1186/s13287-019-1410-y ↗
3. Zhang N, Wang W, Zhang X, et al. The effect of different coatings on bone response and degradation behavior of porous magnesium-strontium devices in segmental defect regeneration. Bioactive Mater, 2021, 6: 1765–177610.1016/j.bioactmat.2020.11.026 ↗
4. Xu S, Zhou Z, Liu Z, et al. Concurrent stiffening and softening in hydrogels under dehydration. Sci Adv, 2023, 9: eade324010.1126/sciadv.ade3240 ↗
5. Wang F, Xu Y, Shi D, et al. Reconstruction of ocular surfaces with limbal stem cells supported by porous composite hydrogels. Sci China Mater, 2024, 67: 2103–211410.1007/s40843-024-2970-2 ↗
6. Bastos AR, da Silva LP, Maia FR, et al. Lactoferrin-hydroxyapatite containing spongy-like hydrogels for bone tissue engineering. Materials, 2019, 12: 207410.3390/ma12132074 ↗
7. Del Bakhshayesh AR, Asadi N, Alihemmati A, et al. An overview of advanced biocompatible and biomimetic materials for creation of replacement structures in the musculoskeletal systems: focusing on cartilage tissue engineering. J Biol Eng, 2019, 13: 8510.1186/s13036-019-0209-9 ↗
8. Tong L, Liu Q, Xiong L, et al. Sustainably releasing osteogenic trace elements from montmorillonite intercalated hybrid nanocomposites accelerates bone regeneration. Sci China Mater, 2024, 67: 2067–207910.1007/s40843-023-2842-3 ↗
9. Neumann M, di Marco G, Iudin D, et al. Stimuli-responsive hydrogels: the dynamic smart biomaterials of tomorrow. Macromolecules, 2023, 56: 8377–839210.1021/acs.macromol.3c00967 ↗
10. Feng W, Wang Z. Tailoring the swelling-shrinkable behavior of hydrogels for biomedical applications. Adv Sci, 2023, 10: 230332610.1002/advs.202303326 ↗
11. Chen W, Zhang H, Zhou Q, et al. Smart hydrogels for bone reconstruction via modulating the microenvironment. Research, 2023, 6: 008910.34133/research.0089 ↗
12. Kilic Boz R, Aydin D, Kocak S, et al. Redox-responsive hydrogels for tunable and “on-demand” release of biomacromolecules. Bioconjugate Chem, 2022, 33: 839–84710.1021/acs.bioconjchem.2c00094 ↗
13. Mao Y, Zhang Y, Wang Y, et al. A multifunctional nanocomposite hydrogel with controllable release behavior enhances bone regeneration. Regen BioMaterials, 2023, 10: rbad04610.1093/rb/rbad046 ↗
14. Peng Z, Du Y, Song M, et al. Dual-functionalized injectable pH-responsive hydrogels loaded with magnesium peroxide for the treatment of implant-associated infection. ACS Appl Mater Interfaces, 2024, 16: 68794–6881510.1021/acsami.4c10912 ↗
15. Zhang W, Lu H, Zhang W, et al. Inflammatory microenvironment-responsive hydrogels enclosed with quorum sensing inhibitor for treating post-traumatic osteomyelitis. Adv Sci, 2024, 11: 230796910.1002/advs.202307969 ↗
16. Rahmanian-Devin P, Baradaran Rahimi V, Askari VR, et al. Thermosensitive chitosan-β-glycerophosphate hydrogels as targeted drug delivery systems: an overview on preparation and their applications. Adv Pharmacol Pharm Sci, 2021, 2021: 1–1710.1155/2021/6640893 ↗
17. Deng A, Kang X, Zhang J, et al. Enhanced gelation of chitosan/β-sodium glycerophosphate thermosensitive hydrogel with sodium bicarbonate and biocompatibility evaluated. Mater Sci Eng-C, 2017, 78: 1147–115410.1016/j.msec.2017.04.109 ↗
18. Wu Y, Xie X, Luo G, et al. Photothermal sensitive nanocomposite hydrogel for infectious bone defects. Bone Res, 2025, 13: 2210.1038/s41413-024-00377-x ↗
19. Zhang F, Feng Q, Zhan J, et al. NIR-activatable antibacterial 3D-printed hydrogel scaffold with controllable drug release for enhanced vascularized bone regeneration. ACS Appl Mater Interfaces, 2025, 17: 40035–4005110.1021/acsami.5c06168 ↗
20. Wang Y, Chen Y, Zhou T, et al. A novel multifunctional nano-composite hydrogel orchestrates the macrophage reprogramming-osteogenesis crosstalk to boost bone defect repair. J Nanobiotechnol, 2024, 22: 70210.1186/s12951-024-02996-2 ↗
21. Niu X, Xiao S, Huang R, et al. ZIF-8-modified hydrogel sequentially delivers angiogenic and osteogenic growth factors to accelerate vascularized bone regeneration. J Control Release, 2024, 374: 154–17010.1016/j.jconrel.2024.08.011 ↗
22. Li J, Ma J, Feng Q, et al. Building osteogenic microenvironments with a double-network composite hydrogel for bone repair. Research, 2023, 6: 002110.34133/research.0021 ↗
23. Li M, Wu H, Gao K, et al. Smart implantable hydrogel for large segmental bone regeneration. Adv Healthcare Mater, 2024, 13: 240291610.1002/adhm.202402916 ↗
24. Chen H, Tan W, Tong T, et al. A pH-responsive asymmetric microfluidic/chitosan device for drug release in infective bone defect treatment. Int J Mol Sci, 2023, 24: 461610.3390/ijms24054616 ↗
25. Zhao Y, Peng X, Wang D, et al. Chloroplast-inspired scaffold for infected bone defect therapy: towards stable photothermal properties and self-defensive functionality. Adv Sci, 2022, 9: 220453510.1002/advs.202204535 ↗
26. Huang Y, Fu Z, Wang H, et al. Calcium peroxide-based hydrogels enable biphasic release of hydrogen peroxide for infected wound healing. Adv Sci, 2024, 11: 240481310.1002/advs.202404813 ↗
27. Bîrcă AC, Gherasim O, Niculescu AG, et al. Infection-free and enhanced wound healing potential of alginate gels incorporating silver and tannylated calcium peroxide nanoparticles. Int J Mol Sci, 2024, 25: 519610.3390/ijms25105196 ↗
28. Xu Y, Zheng S, Tang Z, et al. Injectable, oxygen-releasing, thermosensitive hydrogel promotes vascularized bone formation with prolonged oxygen delivery and improved osteoinductivity. Mater Today Bio, 2024, 29: 10126710.1016/j.mtbio.2024.101267 ↗
29. Islam MM, Shahruzzaman M, Biswas S, et al. Chitosan based bioactive materials in tissue engineering applications—a review. Bioactive Mater, 2020, 5: 164–18310.1016/j.bioactmat.2020.01.012 ↗
30. Shi T, Xiong YH, Song W, et al. Polysaccharide-based antibacterial nanocomposite hydrogels with Janus structure for treatment of infected extraction socket. Sci China Mater, 2024, 67: 2550–255710.1007/s40843-023-2721-5 ↗
31. Zhou HY, Chen XG, Kong M, et al. Effect of molecular weight and degree of chitosan deacetylation on the preparation and characteristics of chitosan thermosensitive hydrogel as a delivery system. Carbohydrate Polyms, 2008, 73: 265–27310.1016/j.carbpol.2007.11.026 ↗
32. Freeman FE, Stevens HY, Owens P, et al. Osteogenic differentiation of mesenchymal stem cells by mimicking the cellular niche of the endochondral template. Tissue Eng Part A, 2016, 22: 1176–119010.1089/ten.tea.2015.0339 ↗
33. Jeong S, Jeon HJ, Jang KJ, et al. Injectable thermosensitive chitosan solution with β-glycerophosphate as an optimal submucosal fluid cushion for endoscopic submucosal dissection. Polymers, 2021, 13: 169610.3390/polym13111696 ↗
34. Chen L, Liu M, Lin L, et al. Thermal-responsive hydrogel surface: tunable wettability and adhesion to oil at the water/solid interface. Soft Matter, 2010, 6: 2708–271210.1039/c002543g ↗
35. Raghuwanshi VS, Joram Mendoza D, Browne C, et al. Effect of temperature on the conformation and functionality of poly(N-isopropylacrylamide) (PNIPAM)-grafted nanocellulose hydrogels. J Colloid Interface Sci, 2023, 652: 1609–161910.1016/j.jcis.2023.08.152 ↗
36. Tavagnacco L, Chiessi E, Zaccarelli E. Molecular insights on poly(N-isopropylacrylamide) coil-to-globule transition induced by pressure. Phys Chem Chem Phys, 2021, 23: 5984–599110.1039/D0CP06452A ↗
37. Ansari MJ, Rajendran RR, Mohanto S, et al. Poly(N-isopropylacrylamide)-based hydrogels for biomedical applications: a review of the state-of-the-art. Gels, 2022, 8: 45410.3390/gels8070454 ↗
38. López-Cano JJ, Sigen A J J, Andrés-Guerrero V, et al. Thermo-responsive PLGA-PEG-PLGA hydrogels as novel injectable platforms for neuroprotective combined therapies in the treatment of retinal degenerative diseases. Pharmaceutics, 2021, 13: 23410.3390/pharmaceutics13020234 ↗
39. Heine S, Aguilar-Pimentel A, Russkamp D, et al. Thermosensitive PLGA–PEG–PLGA hydrogel as depot matrix for allergen-specific immunotherapy. Pharmaceutics, 2022, 14: 152710.3390/pharmaceutics14081527 ↗
40. Piao L, Xiang P, Zhou Y, et al. Thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of EGF to inhibit cervical cancer recurrence. Colloids Surfs B-Biointerfaces, 2024, 236: 11379510.1016/j.colsurfb.2024.113795 ↗
41. Jo SH, Roh S, Shim J, et al. Modulating the thermoresponsive characteristics of PLGA–PEG-PLGA hydrogels via manipulation of PLGA monomer sequences. Biomacromolecules, 2024, 25: 5374–538610.1021/acs.biomac.4c00817 ↗
42. S. AD, P. SPA, Naveen J, et al. Advancement in biomedical implant materials—a mini review. Front Bioeng Biotechnol, 2024, 12: 138973310.3389/fbioe.2024.1389733 ↗
43. Li Y, Xiao L, Wei D, et al. Injectable biomimetic hydrogel guided functional bone regeneration by adapting material degradation to tissue healing. Adv Funct Mater, 2023, 33: 221304710.1002/adfm.202213047 ↗
44. Chen W, Sheng S, Tan K, et al. Injectable hydrogels for bone regeneration with tunable degradability via peptide chirality modification. Mater Horiz, 2024, 11: 4367–437710.1039/D4MH00398E ↗
45. Tian Y, Cui Y, Ren G, et al. Dual-functional thermosensitive hydrogel for reducing infection and enhancing bone regeneration in infected bone defects. Mater Today Bio, 2024, 25: 10097210.1016/j.mtbio.2024.100972 ↗
46. Zhou L, Zhang C, Shi T, et al. Functionalized 3D-printed GelMA/Laponite hydrogel scaffold promotes BMSCs recruitment through osteoimmunomodulatory enhance osteogenic via AMPK/mTOR signaling pathway. Mater Today Bio, 2024, 29: 10126110.1016/j.mtbio.2024.101261 ↗
47. Ding J, Gao B, Mei X. Preparation of photothermal responsive, antibacterial hydrogel by using PVA-Alg and silver nanofibers as building blocks. Front Bioeng Biotechnol, 2023, 11: 122272310.3389/fbioe.2023.1222723 ↗
48. Wang W, Zhang G, Wang Y, et al. An injectable and thermosensitive hydrogel with nano-aided NIR-II phototherapeutic and chemical effects for periodontal antibacteria and bone regeneration. J Nanobiotechnol, 2023, 21: 36710.1186/s12951-023-02124-6 ↗
49. Wu M, Liu H, Li D, et al. Smart-responsive multifunctional therapeutic system for improved regenerative microenvironment and accelerated bone regeneration via mild photothermal therapy. Adv Sci, 2024, 11: 230464110.1002/advs.202304641 ↗
50. Rybak D, Rinoldi C, Nakielski P, et al. Injectable and self-healable nano-architectured hydrogel for NIR-light responsive chemo- and photothermal bacterial eradication. J Mater Chem B, 2024, 12: 1905–192510.1039/D3TB02693K ↗
51. Ma L, Zhang X, Wang H, et al. Two-dimensional Nb2C-based nano-platform augmented sonodynamic antibacterial therapy and bone regeneration. Sci China Mater, 2023, 66: 2913–292410.1007/s40843-022-2413-4 ↗
52. Yin X, Fan T, Zheng N, et al. Palladium nanoparticle based smart hydrogels for NIR light-triggered photothermal/photodynamic therapy and drug release with wound healing capability. Nanoscale Adv, 2023, 5: 1729–173910.1039/D2NA00897A ↗
53. Uusitalo M, Eriksson G, Hulander M, et al. Gold nanorods as photothermal antibacterial materials. ACS Appl Nano Mater, 2025, 8: 3661–367010.1021/acsanm.5c00324 ↗
54. Chen M, Chen XT, Zhang LY, et al. Kinetically and thermodynamically controlled one-pot growth of gold nanoshells with NIR-II absorption for multimodal imaging-guided photothermal therapy. J Nanobiotechnol, 2023, 21: 13810.1186/s12951-023-01907-1 ↗
55. Jakic K, Selc M, Razga F, et al. Long-term accumulation, biological effects and toxicity of BSA-coated gold nanoparticles in the mouse liver, spleen, and kidneys. IJN, 2024, Volume 19: 4103–412010.2147/IJN.S443168 ↗
56. Chen Y, Ma Q, Chen L, et al. Enhanced light-to-thermal conversion performance of self-assembly carbon nanotube/graphene-interconnected phase change materials for thermal-electric device. J Energy Storage, 2023, 72: 10838710.1016/j.est.2023.108387 ↗
57. Peng B, Tian Q, Wei D, et al. Optical phonon branches govern interfacial thermal transport in T-carbon based heterostructures. Int J Heat Mass Transfer, 2025, 242: 12687710.1016/j.ijheatmasstransfer.2025.126877 ↗
58. Yang Y, Shen H, Yang J, et al. Synergistic effect of reduced graphene oxide/carbon nanotube hybrid papers on cross-plane thermal and mechanical properties. RSC Adv, 2022, 12: 19144–1915310.1039/D2RA01723G ↗
59. Wang C, Qing J, Zong H, et al. Heat transfer behavior of graphene-based photothermal conversion materials prepared with tube arrayporous network composite structure. J Appl Phys, 2024, 135: 06500110.1063/5.0180089 ↗
60. Guo Z, Liu X, Lin Y, et al. Hyaluronic acid modified carbon nanotubes using for photothermal therapy by promoting apoptosis of nasopharyngeal carcinoma cells. Front Bioeng Biotechnol, 2023, 11: 122985210.3389/fbioe.2023.1229852 ↗
61. Báez DF. Graphene-based nanomaterials for photothermal therapy in cancer treatment. Pharmaceutics, 2023, 15: 228610.3390/pharmaceutics15092286 ↗
62. García Verdugo KF, Salazar Salas BM, Chan LHC, et al. Nanocomposite hydrogels based on poly(vinyl alcohol) and carbon nanotubes for NIR-light triggered drug delivery. ACS Omega, 2024, 9: 11860–1186910.1021/acsomega.3c09609 ↗
63. Zhang H, Zheng S, Chen C, et al. A graphene hybrid supramolecular hydrogel with high stretchability, self-healable and photothermally responsive properties for wound healing. RSC Adv, 2021, 11: 6367–637310.1039/D0RA09106E ↗
64. Bai X, Wang R, Hu X, et al. Two-dimensional biodegradable black phosphorus nanosheets promote large full-thickness wound healing through in situ regeneration therapy. ACS Nano, 2024, 18: 3553–357410.1021/acsnano.3c11177 ↗
65. Gunathilaka TM, Shimomura M. Nanoscale evaluation of the degradation stability of black phosphorus nanosheets functionalized with PEG and glutathione-stabilized doxorubicin drug-loaded gold nanoparticles in real functionalized system. Molecules, 2024, 29: 174610.3390/molecules29081746 ↗
66. Li H, Xue Y, Zhang T, et al. Black phosphorus nanosheets incorporated mesenchymal stem cell spheroids for accelerated bone regeneration. ACS Appl Nano Mater, 2025, 8: 8963–897610.1021/acsanm.5c01056 ↗
67. Qiu M, Tulufu N, Tang G, et al. Black phosphorus accelerates bone regeneration based on immunoregulation. Adv Sci, 2024, 11: 230482410.1002/advs.202304824 ↗
68. Zhang H, Wang S, Yu Y, et al. Dual-functional injectable photothermal nanohydrogel promotes anti-inflammation and bone regeneration in distraction osteogenesis. Adv Healthcare Mater, 2025, 14: e0260210.1002/adhm.202502602 ↗
69. Qi W, Zhang R, Wang Z, et al. Advances in the application of black phosphorus-based composite biomedical materials in the field of tissue engineering. Pharmaceuticals, 2024, 17: 24210.3390/ph17020242 ↗
70. Kolgesiz S, Ozcelik N, Erdemir NE, et al. Hybrid pectin/polydopamine hydrogels with photothermal properties. ACS Omega, 2025, 10: 21994–2200410.1021/acsomega.5c02084 ↗
71. Li X, Tang J, Guo W, et al. Polydopamine nanocomposite hydrogel for drug slow-release in bone defect repair: a review of research advances. Gels, 2025, 11: 19010.3390/gels11030190 ↗
72. Protsak IS, Morozov YM. Fundamentals and advances in stimuli-responsive hydrogels and their applications: a review. Gels, 2025, 11: 3010.3390/gels11010030 ↗
73. Datta D, Colaco V, Bandi SP, et al. Stimuli-responsive self-healing ionic gels: a promising approach for dermal and tissue engineering applications. ACS BioMater Sci Eng, 2025, 11: 1338–137210.1021/acsbiomaterials.4c02264 ↗
74. Ebrahimi R, Rezanejade Bardajee G. Sonochemical synthesis and swelling behavior of Fe3O4 nanocomposite based on poly(acrylamide-co-acrylic acid) hydrogel for drug delivery application. J Polym Res, 2021, 28: 3510.1007/s10965-020-02382-0 ↗
75. Chen Z, Song X, Soh WWM, et al. In situ synthesis of magnetic poly-(DMAEAB-co-NIPAm)@Fe3O4 composite hydrogel for removal of dye from water. Gels, 2021, 7: 20110.3390/gels7040201 ↗
76. Fischer L, Menzel AM. Magnetically induced elastic deformations in model systems of magnetic gels and elastomers containing particles of mixed size. Smart Mater Struct, 2021, 30: 01400310.1088/1361-665X/abc148 ↗
77. Yu K, Zhou H, Xu Y, et al. Engineering a triple-functional magnetic gel driving mutually-synergistic mild hyperthermia-starvation therapy for osteosarcoma treatment and augmented bone regeneration. J Nanobiotechnol, 2023, 21: 20110.1186/s12951-023-01955-7 ↗
78. Chen M, Tan H, Xu W, et al. A self-healing, magnetic and injectable biopolymer hydrogel generated by dual cross-linking for drug delivery and bone repair. Acta BioMater, 2022, 153: 159–17710.1016/j.actbio.2022.09.036 ↗
79. Zelepukin IV, Yaremenko AV, Ivanov IN, et al. Long-term fate of magnetic particles in mice: a comprehensive study. ACS Nano, 2021, 15: 11341–1135710.1021/acsnano.1c00687 ↗
80. Nowak-Jary J, Machnicka B. Comprehensive analysis of the potential toxicity of magnetic iron oxide nanoparticles for medical applications: cellular mechanisms and systemic effects. Int J Mol Sci, 2024, 25: 1201310.3390/ijms252212013 ↗
81. Chen D, Yin L, Fu Q, et al. A straightforward approach for synthesizing electromechanical sigma-delta MEMS accelerometers. Sensors, 2019, 20: 9110.3390/s20010091 ↗
82. Geng Q, Fu H, Liang X, et al. A conductive composite hydrogel for promoting bone defect regeneration through microcurrent stimulation. Compos Part A-Appl Sci Manufacturing, 2025, 199: 10920510.1016/j.compositesa.2025.109205 ↗
83. McCaig CD, Zhao M. Physiological electrical fields modify cell behaviour. BioEssays, 1997, 19: 819–82610.1002/bies.950190912 ↗
84. Chen Y, Kuang P, Wang Y, et al. Self-healing conductive composite hydrogel for human motion and 3D cell culture monitoring. Sci China Mater, 2023, 66: 4853–486410.1007/s40843-023-2612-3 ↗
85. Jakob DS, Wang H, Xu XG. Pulsed force Kelvin probe force microscopy. ACS Nano, 2020, 14: 4839–484810.1021/acsnano.0c00767 ↗
86. Han L, Liang W, Xie Q, et al. Health monitoring via heart, breath, and Korotkoff sounds by wearable piezoelectret patches. Adv Sci, 2023, 10: 230118010.1002/advs.202301180 ↗
87. Joo S, Gwon Y, Kim S, et al. Piezoelectrically and topographically engineered scaffolds for accelerating bone regeneration. ACS Appl Mater Interfaces, 2024, 16: 1999–201110.1021/acsami.3c12575 ↗
88. Ma Q, Miri Z, Haugen HJ, et al. Significance of mechanical loading in bone fracture healing, bone regeneration, and vascularization. J Tissue Eng, 2023, 14: 2041731423117257310.1177/20417314231172573 ↗
89. Xia P, Shi Y, Wang X, et al. Advances in the application of low-intensity pulsed ultrasound to mesenchymal stem cells. Stem Cell Res Ther, 2022, 13: 21410.1186/s13287-022-02887-z ↗
90. Kaadan A, Salati S, Setti S, et al. Augmentation of deficient bone healing by pulsed electromagnetic fields—from mechanisms to clinical outcomes. Bioengineering, 2024, 11: 122310.3390/bioengineering11121223 ↗
91. Xia Z, Zhang H, Li Q, et al. The biomimetic electrical stimulation system inducing osteogenic differentiations of BMSCs. ACS Appl Mater Interfaces, 2024, 16: 56730–5674310.1021/acsami.4c11890 ↗
92. Li X, Sun Z, Shang X, et al. Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair. Mater Today Bio, 2024, 29: 10137410.1016/j.mtbio.2024.101374 ↗
93. Chen Q, Li J, Han F, et al. A multifunctional composite hydrogel that rescues the ROS microenvironment and guides the immune response for repair of osteoporotic bone defects. Adv Funct Mater, 2022, 32: 220106710.1002/adfm.202201067 ↗
94. Li W, Bei Y, Pan X, et al. Selenide-linked polydopamine-reinforced hybrid hydrogels with on-demand degradation and light-triggered nanozyme release for diabetic wound healing. BioMater Res, 2023, 27: 4910.1186/s40824-023-00367-w ↗
95. Chen W, Zhou Z, Chen D, et al. Bone regeneration using MMP-cleavable peptides-based hydrogels. Gels, 2021, 7: 19910.3390/gels7040199 ↗
96. Wu Y, Li X, Sun Y, et al. Multiscale design of stiffening and ROS scavenging hydrogels for the augmentation of mandibular bone regeneration. Bioactive Mater, 2023, 20: 111–12510.1016/j.bioactmat.2022.05.021 ↗
97. Sun H, Xu J, Wang Y, et al. Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair. Bioactive Mater, 2023, 24: 477–49610.1016/j.bioactmat.2022.12.021 ↗
98. Huang Q, Qu Y, Tang M, et al. ROS-responsive hydrogel for bone regeneration: controlled dimethyl fumarate release to reduce inflammation and enhance osteogenesis. Acta BioMater, 2025, 195: 183–20010.1016/j.actbio.2025.02.026 ↗
99. Sheng W, Qin H, Wang T, et al. Advanced phosphocreatine-grafted chitosan hydrogel promote wound healing by macrophage modulation. Front Bioeng Biotechnol, 2023, 11: 119993910.3389/fbioe.2023.1199939 ↗
100. Chen Y, Zhao Q. Innovative modification strategies and emerging applications of natural hydrogel scaffolds for osteoporotic bone defect regeneration. Front Bioeng Biotechnol, 2025, 13: 159189610.3389/fbioe.2025.1591896 ↗