Stable and low-resistance polydopamine methacrylamide-polyacrylamide hydrogel for brain-computer interface
Source abstract
Abstract
硬质金属电极与柔软人体皮肤之间的界面失效会导致脑机接口器件的信号漂移和性能不稳定, 影响脑电信号的精确采集. 本研究设计并制备了一种聚多巴胺甲基丙烯酰胺-聚丙烯酰胺(PDMA-PAAM)水凝胶. 将多巴胺引入到聚丙烯酰胺水凝胶中, 通过多巴胺的氨基与邻苯二酚基团在有机-无机界面上建立共价和非共价相互作用提高了界面粘结力. 金属电极与人体皮肤之间形成了强附着和有效模量过渡体系, PDMA-PAAM水凝胶与猪皮之间的剥离力达到22 N m−1. 此外, 通过添加氯化钠和甘油, PDMA-PAAM水凝胶具有稳定的电导率和室温下60天以上的长期使用寿命. 将本研究制备的PDMA-PAAM水凝胶集成在柔性金电极上用于脑机接口, 采集到的脑电信号强度和波形与同类商用产品基本一致, 且PDMA-PAAM水凝胶柔性电极具有更稳定的界面.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Neuroscience and Neural Engineering · EEG and Brain-Computer Interfaces
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (52)
Show source-provided references
1. Nelson PG, Brenneman DE. Electrical activity of neurons and development of the brain. Trends Neuroscis, 1982, 5: 229–23210.1016/0166-2236(82)90133-3 ↗
2. Alivisatos AP, Andrews AM, Boyden ES, et al. Nanotools for neuroscience and brain activity mapping. ACS Nano, 2013, 7: 1850–186610.1021/nn4012847 ↗
3. Ma Y, Zhang Y, Cai S, et al. Flexible hybrid electronics for digital healthcare. Adv Mater, 2020, 32: 190206210.1002/adma.201902062 ↗
4. Minev IR, Musienko P, Hirsch A, et al. Electronic dura mater for long-term multimodal neural interfaces. Science, 2015, 347: 159–16310.1126/science.1260318 ↗
5. Rios G, Lubenov EV, Chi D, et al. Nanofabricated neural probes for dense 3-D recordings of brain activity. Nano Lett, 2016, 16: 6857–686210.1021/acs.nanolett.6b02673 ↗
6. Wang J, Thow XY, Wang H, et al. A highly selective 3D spiked ultraflexible neural (SUN) interface for decoding peripheral nerve sensory information. Adv Healthcare Mater, 2017, 7: 170098710.1002/adhm.201700987 ↗
7. Lee B, Koripalli MK, Jia Y, et al. An implantable peripheral nerve recording and stimulation system for experiments on freely moving animal subjects. Sci Rep, 2018, 8: 611510.1038/s41598-018-24465-1 ↗
8. Yang J, Liu L, Li T, et al. Array focal cortical stimulation enhances motor function recovery and brain remodeling in a rat model of ischemia. J Stroke Cerebrovasc Dis, 2017, 26: 658–66510.1016/j.jstrokecerebrovasdis.2016.11.009 ↗
9. Nam J, Lim HK, Kim NH, et al. Supramolecular peptide hydrogel-based soft neural interface augments brain signals through a three-dimensional electrical network. ACS Nano, 2020, 14: 664–67510.1021/acsnano.9b07396 ↗
10. Grill WM, Norman SE, Bellamkonda RV. Implanted neural interfaces: Biochallenges and engineered solutions. Annu Rev Biomed Eng, 2009, 11: 1–2410.1146/annurev-bioeng-061008-124927 ↗
11. Bettinger CJ. Recent advances in materials and flexible electronics for peripheral nerve interfaces. Bioelectron Med, 2018, 4: 110.1186/s42234-018-0007-6 ↗
12. Won SM, Song E, Zhao J, et al. Recent advances in materials, devices, and systems for neural interfaces. Adv Mater, 2018, 30: 180053410.1002/adma.201800534 ↗
13. Lee M, Shim HJ, Choi C, et al. Soft high-resolution neural interfacing probes: Materials and design approaches. Nano Lett, 2019, 19: 2741–274910.1021/acs.nanolett.8b04895 ↗
14. Li H, Liu H, Sun M, et al. 3D interfacing between soft electronic tools and complex biological tissues. Adv Mater, 2021, 33: 200442510.1002/adma.202004425 ↗
15. Pedrosa P, Fiedler P, Schinaia L, et al. Alginate-based hydrogels as an alternative to electrolytic gels for rapid EEG monitoring and easy cleaning procedures. Sens Actuat B-Chem, 2017, 247: 273–28310.1016/j.snb.2017.02.164 ↗
16. Chen Y, Liu F, Lu B, et al. Skin-like hybrid integrated circuits conformal to face for continuous respiratory monitoring. Adv Electron Mater, 2020, 6: 200014510.1002/aelm.202000145 ↗
17. Debener S, Emkes R, De Vos M, et al. Unobtrusive ambulatory EEG using a smartphone and flexible printed electrodes around the ear. Sci Rep, 2015, 5: 1674310.1038/srep16743 ↗
18. Valentin O, Viallet G, Delnavaz A, et al. Custom-fitted in- and around-the-ear sensors for unobtrusive and on-the-go EEG acquisitions: Development and validation. Sensors, 2021, 21: 295310.3390/s21092953 ↗
19. Jiang X, Bian GB, Tian Z. Removal of artifacts from EEG signals: A review. Sensors, 2019, 19: 98710.3390/s19050987 ↗
20. Frankel MA, Lehmkuhle MJ, Watson M, et al. Electrographic seizure monitoring with a novel, wireless, single-channel EEG sensor. Clin Neurophysiol Pract, 2021, 6: 172–17810.1016/j.cnp.2021.04.003 ↗
21. Bleichner MG, Debener S. Concealed, unobtrusive ear-centered EEG acquisition: cEEGrids for transparent EEG. Front Hum Neurosci, 2017, 11: 16310.3389/fnhum.2017.00163 ↗
22. Bleichner MG, Mirkovic B, Debener S. Identifying auditory attention with ear-EEG: cEEGrid versus high-density cap-EEG comparison. J Neural Eng, 2016, 13: 06600410.1088/1741-2560/13/6/066004 ↗
23. Sterr A, Ebajemito JK, Mikkelsen KB, et al. Sleep EEG derived from behind-the-ear electrodes (cEEGrid) compared to standard polysomnography: A proof of concept study. Front Hum Neurosci, 2018, 12: 45210.3389/fnhum.2018.00452 ↗
24. Sheng H, Wang X, Kong N, et al. Neural interfaces by hydrogels. Extreme Mech Lett, 2019, 30: 10051010.1016/j.eml.2019.100510 ↗
25. Yuk H, Lu B, Lin S, et al. 3D printing of conducting polymers. Nat Commun, 2020, 11: 160410.1038/s41467-020-15316-7 ↗
26. Wong TH, Yiu CK, Zhou J, et al. Tattoo-like epidermal electronics as skin sensors for human machine interfaces. Soft Sci, 2021, 1: 10
27. Oribe S, Yoshida S, Kusama S, et al. Hydrogel-based organic subdural electrode with high conformability to brain surface. Sci Rep, 2019, 9: 1337910.1038/s41598-019-49772-z ↗
28. Wirthl D, Pichler R, Drack M, et al. Instant tough bonding of hydrogels for soft machines and electronics. Sci Adv, 2017, 3: e170005310.1126/sciadv.1700053 ↗
29. Kim SH, Jung S, Yoon IS, et al. Ultrastretchable conductor fabricated on skin-like hydrogel-elastomer hybrid substrates for skin electronics. Adv Mater, 2018, 30: 180010910.1002/adma.201800109 ↗
30. Zhu J, Zhou C, Zhang M. Recent progress in flexible tactile sensor systems: From design to application. SS, 2021, 1: 3
31. Lim C, Hong YJ, Jung J, et al. Tissue-like skin-device interface for wearable bioelectronics by using ultrasoft, mass-permeable, and low-impedance hydrogels. Sci Adv, 2021, 7: eabd371610.1126/sciadv.abd3716 ↗
32. Wellman SM, Eles JR, Ludwig KA, et al. A materials roadmap to functional neural interface design. Adv Funct Mater, 2017, 28: 170126910.1002/adfm.201701269 ↗
33. Ge W, Cao S, Yang Y, et al. Nanocellulose/LiCl systems enable conductive and stretchable electrolyte hydrogels with tolerance to dehydration and extreme cold conditions. Chem Eng J, 2021, 408: 12730610.1016/j.cej.2020.127306 ↗
34. Pan X, Wang Q, Ning D, et al. Ultraflexible self-healing guar gum-glycerol hydrogel with injectable, antifreeze, and strain-sensitive properties. ACS Biomater Sci Eng, 2018, 4: 3397–340410.1021/acsbiomaterials.8b00657 ↗
35. Peng S, Liu S, Sun Y, et al. Facile preparation and characterization of poly(vinyl alcohol)-NaCl-glycerol supramolecular hydrogel electrolyte. Eur Polym J, 2018, 106: 206–21310.1016/j.eurpolymj.2018.07.024 ↗
36. Zhang Q, Liu X, Duan L, et al. Ultra-stretchable wearable strain sensors based on skin-inspired adhesive, tough and conductive hydrogels. Chem Eng J, 2019, 365: 10–1910.1016/j.cej.2019.02.014 ↗
37. Shao C, Wang M, Meng L, et al. Mussel-inspired cellulose nanocomposite tough hydrogels with synergistic self-healing, adhesive, and strain-sensitive properties. Chem Mater, 2018, 30: 3110–312110.1021/acs.chemmater.8b01172 ↗
38. He X, Liu L, Han H, et al. Bioinspired and microgel-tackified adhesive hydrogel with rapid self-healing and high stretchability. Macromolecules, 2018, 52: 72–8010.1021/acs.macromol.8b01678 ↗
39. Han L, Liu K, Wang M, et al. Mussel-inspired adhesive and conductive hydrogel with long-lasting moisture and extreme temperature tolerance. Adv Funct Mater, 2017, 28: 170419510.1002/adfm.201704195 ↗
40. Wu L, Li L, Qu M, et al. Mussel-inspired self-adhesive, antidrying, and antifreezing poly(acrylic acid)/bentonite/polydopamine hybrid glycerol-hydrogel and the sensing application. ACS Appl Polym Mater, 2020, 2: 3094–310610.1021/acsapm.0c00264 ↗
41. Yan Y, Huang J, Qiu X, et al. An ultra-stretchable glycerol-ionic hybrid hydrogel with reversible gelid adhesion. J Colloid Interface Sci, 2021, 582: 187–20010.1016/j.jcis.2020.08.008 ↗
42. Zhu HW, Zhang JN, Su P, et al. Strong adhesion of poly(vinyl alcohol)-glycerol hydrogels onto metal substrates for marine antifouling applications. Soft Matter, 2020, 16: 709–71710.1039/C9SM01413F ↗
43. Dreyer DR, Miller DJ, Freeman BD, et al. Elucidating the structure of poly(dopamine). Langmuir, 2012, 28: 6428–643510.1021/la204831b ↗
44. Liebscher J, Mrówczyński R, Scheidt HA, et al. Structure of polydopamine: A never-ending story? Langmuir, 2013, 29: 10539–1054810.1021/la4020288 ↗
45. Liu Y, Ai K, Lu L. Polydopamine and its derivative materials: Synthesis and promising applications in energy, environmental, and biomedical fields. Chem Rev, 2014, 114: 5057–511510.1021/cr400407a ↗
46. Han L, Lu X, Wang M, et al. A mussel-inspired conductive, self-adhesive, and self-healable tough hydrogel as cell stimulators and implantable bioelectronics. Small, 2017, 13: 160191610.1002/smll.201601916 ↗
47. Yu QH, Zhang CM, Jiang ZW, et al. Mussel-inspired adhesive polydopamine-functionalized hyaluronic acid hydrogel with potential bacterial inhibition. Glob Challenges, 2020, 4: 190006810.1002/gch2.201900068 ↗
48. Han L, Wang M, Li P, et al. Mussel-inspired tissue-adhesive hydrogel based on the polydopamine-chondroitin sulfate complex for growth-factor-free cartilage regeneration. ACS Appl Mater Interfaces, 2018, 10: 28015–2802610.1021/acsami.8b05314 ↗
49. Yang Z, Huang R, Zheng B, et al. Highly stretchable, adhesive, biocompatible, and antibacterial hydrogel dressings for wound healing. Adv Sci, 2021, 8: 200362710.1002/advs.202003627 ↗
50. Han L, Lu X, Liu K, et al. Mussel-inspired adhesive and tough hydrogel based on nanoclay confined dopamine polymerization. ACS Nano, 2017, 11: 2561–257410.1021/acsnano.6b05318 ↗
51. Wang C, Zhao N, Yuan W. NIR/thermoresponsive injectable self-healing hydrogels containing polydopamine nanoparticles for efficient synergistic cancer thermochemotherapy. ACS Appl Mater Interfaces, 2020, 12: 9118–913110.1021/acsami.9b23536 ↗
52. Kaveh R, Doong J, Zhou A, et al. Wireless user-generic ear EEG. IEEE Trans Biomed Circuits Syst, 2020, 14: 727–73710.1109/TBCAS.2020.3001265 ↗