DataVXScience and Technology of Advanced MaterialsPaper
journal article·2020-01-31Open access

Synthesis and characterization of phenylboronic acid-containing polymer for glucose-triggered drug delivery+

Guihua Cui, Kunming Zhao, Kewei You, Zhengguo Gao, Toyoji Kakuchi, Bo Feng, Qian Duan

Science and Technology of Advanced Materials· Volume 21· Issue 1
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Source abstract

Abstract

Thermo-, pH- and glucose-responsive polymeric nanoparticles are of great interest in developing a self-regulated drug delivery system. The novel core-shell nanoparticles were synthesized by self-assembly of a phenylboronic acid-based block copolymer poly-(N-isopropylacrylamide)-block-poly(3-acrylamidophenylboronic acid) (PNIPAM136-b-PAPBA16) and a fluorescent complex glucosamine-poly(N-isopropylacrylamide)/Eu(III) (GA-PNIPAM)/Eu(III) based on the cross-linking between PBA- and GA-containing blocks in this work. The nanoparticles can be tuned via thermo-induced collapse or glucose-induced swelling at appropriate pH and temperatures; they had an average kinetic radius was about 80nm, and which showed excellent fluorescence. MTT assays revealed the nanocarriers had no significant cytotoxic response of the micelle when it was observed in the cell line over the concentration range from 0.1 to 1000 μg/ml at any exposure times.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced Polymer Synthesis and Characterization · Hydrogels: synthesis, properties, applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for Biomaterials, Jilin Medical University, Jilin, China

Department of Materials Science and Engineering, Changchun University of Science and Technology, Changchun, Jilin, China

Department of Research, Redpharm Biotechnology Co., Ltd, Beijing, China

Chemical and Engineering College, Yantai University, Yantai, Shandong, China

Division of Biotechnology and Macromolecular Chemistry, Graduate School of Engineering, Hokkaido University, Sapporo, Japan

Department of Pharmacy, Jilin Medical University, Jilin, China

Funding

Jilin Province Science and Technology project of traditional Chinese medicine · The science and technology development project · Jilin Province Education Department the Science and Technology development project · Jilin Province Health and health Commission · Jilin City Science and Technology Innovation development project · National College Student Innovation Training Program

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