Repair calvarial defect of osteoporotic rats by berberine functionalized porous calcium phosphate scaffold
Source abstract
Abstract
Abstract In this article, we propose a simple scheme of using berberine (BBR) to modify porous calcium phosphate ceramics (named PCPC). These BBR molecules regulate the crystallization of hydroxyapatite nanorods on PCPC. We found that these nanorods and the adsorbed BBR changed the interface micro-environment of PCPC by SEM images. The microenvironment of PCPC surface is essential for promoting BMSCs’ proliferation and differentiation. These results demonstrated that PCPC/BBR markedly improved the bone regeneration of osteoporosis rats. Moreover, PCPC/BBR had significantly increased the expression levels of ALP, osteocalcin and bone morphogenetic protein2 and RUNX2 in BMSCs originated from osteoporosis rats.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Periodontal Regeneration and Treatments · Dental Implant Techniques and Outcomes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China
Jinzhou Medical University, Jinzhou 121001, China
Funding
National Natural Science Foundation of China
References (41)
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