Preparation and characterization of methacrylated gelatin/bacterial cellulose composite hydrogels for cartilage tissue engineering
Source abstract
Abstract
Abstract Methacrylated gelatin (GelMA)/bacterial cellulose (BC) composite hydrogels have been successfully prepared by immersing BC particles in GelMA solution followed by photo-crosslinking. The morphology of GelMA/BC hydrogel was examined by scanning electron microscopy and compared with pure GelMA. The hydrogels had very well interconnected porous network structure, and the pore size decreased from 200 to 10 µm with the increase of BC content. The composite hydrogels were also characterized by swelling experiment, X-ray diffraction, thermogravimetric analysis, rheology experiment and compressive test. The composite hydrogels showed significantly improved mechanical properties compared with pure GelMA. In addition, the biocompatility of composite hydrogels were preliminarily evaluated using human articular chondrocytes. The cells encapsulated within the composite hydrogels for 7 days proliferated and maintained the chondrocytic phenotype. Thus, the GelMA/BC composite hydrogels might be useful for cartilage tissue engineering.
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Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Silk-based biomaterials and applications · Wound Healing and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Medical College, Guizhou University, Guiyang 550025, China
Department of Rehabilitation, Guizhou Provincial People’s Hospital, Guiyang 550002, China
Center for Joint Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China
Department of Orthopedics, Guizhou Provincial People’s Hospital, Guiyang 550002, China
Zunyi Traditional Chinese Medicine Hospital, Zunyi 563099, China
Funding
Science Foundation of Guizhou Province
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