Functional biomaterials for tendon/ligament repair and regeneration
Source abstract
Abstract
Abstract With an increase in life expectancy and the popularity of high-intensity exercise, the frequency of tendon and ligament injuries has also increased. Owing to the specificity of its tissue, the rapid restoration of injured tendons and ligaments is challenging for treatment. This review summarizes the latest progress in cells, biomaterials, active molecules and construction technology in treating tendon/ligament injuries. The characteristics of supports made of different materials and the development and application of different manufacturing methods are discussed. The development of natural polymers, synthetic polymers and composite materials has boosted the use of scaffolds. In addition, the development of electrospinning and hydrogel technology has diversified the production and treatment of materials. First, this article briefly introduces the structure, function and biological characteristics of tendons/ligaments. Then, it summarizes the advantages and disadvantages of different materials, such as natural polymer scaffolds, synthetic polymer scaffolds, composite scaffolds and extracellular matrix (ECM)-derived biological scaffolds, in the application of tendon/ligament regeneration. We then discuss the latest applications of electrospun fiber scaffolds and hydrogels in regeneration engineering. Finally, we discuss the current problems and future directions in the development of biomaterials for restoring damaged tendons and ligaments.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Tendon Structure and Treatment · Shoulder Injury and Treatment · Knee injuries and reconstruction techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025, P. R. China
Funding
National Key Research and Development Program of China
References (100+)
Show source-provided references
1. Tissue engineering strategies in ligament regeneration10.1155/2012/374676 ↗
2. Gatt · 2022
3. The pathogenesis of tendinopathy. A molecular perspective10.1093/rheumatology/keg448 ↗
4. Clinical practice. Rotator-cuff failure10.1056/NEJMcp0800814 ↗
5. Hamstring autograft versus patellar tendon autograft for ACL reconstruction: is there a difference in graft failure rate? A meta-analysis of 47,613 patients10.1007/s11999-017-5278-9 ↗
6. Rotator cuff rehabilitation: current theories and practice10.1080/00913847.2016.1108883 ↗
7. Trends and epidemiology of knee extensor mechanism injuries presenting to united states emergency departments from 2001 TO 202010.1080/00913847.2021.2024775 ↗
8. Epidemiology of Achilles tendon ruptures: increasing incidence over a 33-year period10.1111/sms.12253 ↗
9. Increasing incidence of rotator cuff repairs—a nationwide registry study in Finland10.1186/s12891-015-0639-6 ↗
10. Epidemiology of Achilles tendon ruptures in the United States: athletic and nonathletic injuries from 2012 to 201610.1177/2325967118808238 ↗
11. Tendon and ligament genetics: how do they contribute to disease and injury? A narrative review10.3390/life12050663 ↗
12. The epiligament: structure, postnatal development and role in ligament healing
13. The role of the non-collagenous extracellular matrix in tendon and ligament mechanical behavior: a review10.1115/1.4053086 ↗
14. Opportunities and challenges of hydrogel microspheres for tendon-bone healing after anterior cruciate ligament reconstruction10.1002/jbm.b.34925 ↗
15. Hsu · 2022
16. Varacallo · 2022
17. Tendon injury: from biology to tendon repair10.1038/nrrheum.2015.26 ↗
18. Tendon development and diseases10.1002/wdev.201 ↗
19. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading10.1152/physrev.00031.2003 ↗
20. Ackermann · 2016 · V10.1007/978-3-319-33943-6 ↗
21. Tendon tissue engineering: cells, growth factors, scaffolds and production techniques10.1016/j.jconrel.2021.03.040 ↗
22. The structure and function of the anterolateral ligament of the knee: a systematic review10.1016/j.arthro.2014.12.015 ↗
23. Processing of collagen based biomaterials and the resulting materials properties10.1186/s12938-019-0647-0 ↗
24. A clinical, biological, and biomaterials perspective into tendon injuries and regeneration10.1089/ten.teb.2016.0181 ↗
25. Tendon grafts: their natural history, biology and future development10.1177/1753193415595176 ↗
26. Tendon injury and repair—a perspective on the basic mechanisms of tendon disease and future clinical therapy10.1016/j.actbio.2017.08.032 ↗
27. Regeneration and repair of tendon and ligament tissue using collagen fibre biomaterials10.1016/j.actbio.2011.06.002 ↗
28. Tissue engineering of cartilage, tendon and bone10.1007/s11684-011-0122-1 ↗
29. Therapeutic strategies for tendon healing based on novel biomaterials, factors and cells10.1159/000347059 ↗
30. Anterior cruciate ligament reconstruction, rehabilitation, and return to play: 2015 update10.2147/OAJSM.S72332 ↗
31. Strategies to engineer tendon/ligament-to-bone interface: biomaterials, cells and growth factors10.1016/j.addr.2015.03.004 ↗
32. Arthroscopic replacement of massive, irreparable rotator cuff tears using a GraftJacket allograft: technique and preliminary results10.1016/j.arthro.2007.07.033 ↗
33. Tendon fascicle-inspired nanofibrous scaffold of polylactic acid/collagen with enhanced 3D-Structure and biomechanical properties10.1038/s41598-018-35536-8 ↗
34. Mechanical factors in embryonic tendon development: potential cues for stem cell tenogenesis10.1016/j.copbio.2013.07.003 ↗
35. Tissue engineering in hand surgery: a technology update10.1016/j.jhsa.2017.06.014 ↗
36. Biodegradable polymer nanocomposites for ligament/tendon tissue engineering10.1186/s12951-019-0556-1 ↗
37. Woven collagen biotextiles enable mechanically functional rotator cuff tendon regeneration during repair of segmental tendon defects in vivo10.1002/jbm.b.34279 ↗
38. Tendinopathy10.1038/s41572-020-00234-1 ↗
39. Effect of diabetes on tendon structure and function: not limited to collagen crosslinking10.1177/19322968221100842 ↗
40. Rapid fabrication of tendon-like collagen gel via simultaneous fibre alignment and intermolecular cross-linking under mechanical loading10.1088/1748-605X/ac7305 ↗
41. Synergistic effects of mechanical stimulation and crimped topography to stimulate natural collagen development for tendon engineering10.1016/j.actbio.2022.04.026 ↗
42. Rotator cuff repair with autologous tenocytes and biodegradable collagen scaffold: a histological and biomechanical study in sheep10.1177/0363546519892580 ↗
43. Oriented collagen fiber membranes formed through counter-rotating extrusion and their application in tendon regeneration10.1016/j.biomaterials.2019.03.041 ↗
44. Driving hierarchical collagen fiber formation for functional tendon, ligament, and meniscus replacement10.1016/j.biomaterials.2020.120527 ↗
45. Influence of different surface modification treatments on silk biotextiles for tissue engineering applications10.1002/jbm.b.33400 ↗
46. Restorative and pain-relieving effects of fibroin in preclinical models of tendinopathy10.1016/j.biopha.2022.112693 ↗
47. Co-Electrospun silk fibroin and gelatin methacryloyl sheet seeded with mesenchymal stem cells for tendon regeneration10.1002/smll.202107714 ↗
48. Silk fibroin as a functional biomaterial for tissue engineering10.3390/ijms22031499 ↗
49. Fabrication and characterization of biphasic silk fibroin scaffolds for tendon/ligament-to-bone tissue engineering10.1089/ten.tea.2016.0460 ↗
50. Knitted silk-collagen scaffold incorporated with ligament stem/progenitor cells sheet for anterior cruciate ligament reconstruction and osteoarthritis prevention10.1021/acsbiomaterials.9b01041 ↗
51. Oxidized alginate-based hydrogels for tissue engineering applications: a review10.1021/acs.biomac.7b01331 ↗
52. Radio-metal cross-linking of alginate hydrogels for non-invasive in vivo imaging10.1016/j.biomaterials.2020.119930 ↗
53. Review of alginate-based hydrogel bioprinting for application in tissue engineering10.1088/1758-5090/ab331e ↗
54. Sustained delivery of transforming growth factor beta 1 by use of absorbable alginate scaffold enhances rotator cuff healing in a rabbit model10.1177/0363546518757759 ↗
55. Biomimetic multilayer polycaprolactone/sodium alginate hydrogel scaffolds loaded with melatonin facilitate tendon regeneration10.1016/j.carbpol.2021.118865 ↗
56. Mechanically competent chitosan-based bioadhesive for tendon-to-bone repair10.1002/adhm.202102344 ↗
57. Chitosan/alginate crosslinked hydrogels: preparation, characterization and application for cell growth purposes10.1016/j.ijbiomac.2013.04.073 ↗
58. Possibilities and limitations of electrospun chitosan-coated polycaprolactone grafts for rotator cuff tear repair10.1002/term.2985 ↗
59. Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity10.1038/s41551-021-00810-0 ↗
60. Microengineered multicomponent hydrogel fibers: combining polyelectrolyte complexation and microfluidics10.1021/acsbiomaterials.6b00331 ↗
61. Low molecular weight hyaluronic acid (500–730 kda) injections in tendinopathies—a narrative review10.3390/jfmk7010003 ↗
62. The impact of hyaluronic acid on tendon physiology and its clinical application in tendinopathies10.3390/cells10113081 ↗
63. Clinical efficacy of ultrasound-guided hyaluronic acid injections in patients with supraspinatus tendon tear10.55563/clinexprheumatol/cyiyy3 ↗
64. Polymer-based constructs for flexor tendon repair: a review10.3390/polym14050867 ↗
65. Histopathological and immunohistochemical evaluation of cellular response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch for tendon repair10.1038/s41598-020-61725-5 ↗
66. Biomaterials strategies to balance inflammation and tenogenesis for tendon repair10.1016/j.actbio.2021.05.043 ↗
67. Human adipose stem cells differentiated on braided polylactide scaffolds is a potential approach for tendon tissue engineering10.1089/ten.tea.2015.0276 ↗
68. Electrospun PLGA fiber diameter and alignment of tendon biomimetic fleece potentiate tenogenic differentiation and immunomodulatory function of amniotic epithelial stem cells10.3390/cells9051207 ↗
69. Synthesis of PLA-poly(ether urethane)-PLA copolymers and design of biodegradable anti-adhesive membranes for orthopaedic applications10.1039/D0TB02545C ↗
70. Rotator cuff repair using a bioresorbable nanofiber interposition scaffold: a biomechanical and histologic analysis in sheep10.1016/j.jse.2021.07.018 ↗
71. Elastic materials for tissue engineering applications: natural, synthetic, and hybrid polymers10.1016/j.actbio.2018.08.027 ↗
72. Exosome-delivered BMP-2 and polyaspartic acid promotes tendon bone healing in rotator cuff tear via Smad/RUNX2 signaling pathway10.1080/21655979.2021.2019871 ↗
73. Design and evaluation of collagen-inspired mineral-hydrogel nanocomposites for bone regeneration10.1016/j.actbio.2020.05.034 ↗
74. Assessment of sheep knee joint after ACL replacement with Achilles tendon autograft and PLA-based implant10.1016/j.jmbbm.2021.104923 ↗
75. Tissue engineering and regenerative medicine: history, progress, and challenges10.1146/annurev-chembioeng-061010-114257 ↗
76. Poly lactic-co-glycolic acid scaffold loaded with plasmid DNA encoding fibroblast growth factor-2 promotes periodontal ligament regeneration of replanted teeth10.1111/jre.12734 ↗
77. Sustained BMP-2 release and platelet rich fibrin synergistically promote tendon-bone healing after anterior cruciate ligament reconstruction in rat
78. Controlled release of bFGF loaded into electrospun core–shell fibrous membranes for use in guided tissue regeneration10.1088/1748-605X/ab7979 ↗
79. Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments10.1016/j.bioactmat.2022.04.003 ↗
80. Bioactive silk Fibroin-Based hybrid biomaterials for musculoskeletal engineering: recent progress and perspectives10.1021/acsabm.1c00654 ↗
81. Musculoskeletal tissue engineering using fibrous biomaterials10.1007/978-1-0716-0845-6_4 ↗
82. Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling10.1089/ten.2006.12.3285 ↗
83. Tissue-engineered magnetic cell sheet patches for advanced strategies in tendon regeneration10.1016/j.actbio.2017.09.014 ↗
84. Mesenchymal stem cell interacted with PLCL braided scaffold coated with poly-l-lysine/hyaluronic acid for ligament tissue engineering10.1002/jbm.a.36494 ↗
85. Hybrid interpenetrating hydrogel network favoring the bidirectional migration of tenocytes for rotator cuff tendon regeneration10.1002/jbm.b.34924 ↗
86. Gel-spinning of mimetic collagen and collagen/nano-carbon fibers: understanding multi-scale influences on molecular ordering and fibril alignment10.1016/j.jmbbm.2016.08.022 ↗
87. Magneto-mechanical actuation of magnetic responsive fibrous scaffolds boosts tenogenesis of human adipose stem cells10.1039/C9NR04355A ↗
88. Scaffolding strategies for tissue engineering and regenerative medicine applications10.3390/ma12111824 ↗
89. Preparation of collagen/polyurethane/knitted silk as a composite scaffold for tendon tissue engineering10.1177/0954411917697751 ↗
90. "Swiss roll"-like bioactive hybrid scaffolds for promoting bone tissue ingrowth and tendon-bone healing after anterior cruciate ligament reconstruction10.1039/C9BM01703H ↗
91. Sustained release of amnion-derived cellular cytokine solution facilitates achilles tendon healing in rats
92. The utilization of decellularized tendon slices to provide an inductive microenvironment for the proliferation and tenogenic differentiation of stem cells10.1016/j.biomaterials.2015.02.061 ↗
93. The role of the tendon ECM in mechanotransduction: disruption and repair following overuse10.1080/03008207.2021.1925663 ↗
94. Solubilized extracellular matrix bioscaffolds derived from diverse source tissues differentially influence macrophage phenotype10.1002/jbm.a.35894 ↗
95. Tendon extracellular matrix assembly, maintenance and dysregulation throughout life10.1007/978-3-030-80614-9_3 ↗
96. Decellularized tendon matrix membranes prevent post-surgical tendon adhesion and promote functional repair10.1016/j.actbio.2021.07.038 ↗
97. Collagen and chondroitin sulfate functionalized bioinspired fibers for tendon tissue engineering application10.1016/j.ijbiomac.2020.12.152 ↗
98. Use of a novel, reinforced, low immunogenic, porcine small intestine submucosa patch to repair a supraspinatus tendon defect in a rabbit model
99. Dehydrated human amniotic membrane regulates tenocyte expression and angiogenesis in vitro: implications for a therapeutic treatment of tendinopathy10.1002/jbm.b.34951 ↗
100. Tendon extracellular matrix remodeling and defective cell polarization in the presence of collagen VI mutations10.3390/cells9020409 ↗