journal article·2023-01-17Open access

Aggregation-induced emission biomaterials for anti-pathogen medical applications: detecting, imaging and killing

Zicong Zhang, Ziwei Deng, Lixun Zhu, Jialin Zeng, Xu Min Cai, Zijie Qiu, Zheng Zhao, Ben Zhong Tang

Abstract

Abstract Microbial pathogens, including bacteria, fungi and viruses, greatly threaten the global public health. For pathogen infections, early diagnosis and precise treatment are essential to cut the mortality rate. The emergence of aggregation-induced emission (AIE) biomaterials provides an effective and promising tool for the theranostics of pathogen infections. In this review, the recent advances about AIE biomaterials for anti-pathogen theranostics are summarized. With the excellent sensitivity and photostability, AIE biomaterials have been widely applied for precise diagnosis of pathogens. Besides, different types of anti-pathogen methods based on AIE biomaterials will be presented in detail, including chemotherapy and phototherapy. Finally, the existing deficiencies and future development of AIE biomaterials for anti-pathogen applications will be discussed.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Luminescence and Fluorescent Materials · Nanoplatforms for cancer theranostics · Polydiacetylene-based materials and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Clinical Translational Research Center of Aggregation-Induced Emission, The Second Affiliated Hospital, School of Medicine, School of Science and Engineering, Shenzhen Key Laboratory of Functional Aggregate Materials, The Chinese University of Hong Kong , Shenzhen, Guangdong 518172, China

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Rescources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University , Nanjing 210037, China

HKUST-Shenzhen Research Institute, South Area Hi-Tech Park , Nanshan, Shenzhen, Guangdong Province 518057, China

Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon, Hong Kong, China

Funding

NSFC · Shenzhen Key Laboratory of Functional Aggregate Materials

References (100+)

Show source-provided references
1. Infectious diseases and human population history10.2307/1312814 ↗
2. A review on recent diseases caused by microbes
3. The Johns Hopkins university center for systems science and engineering COVID-19 dashboard: data collection process, challenges faced, and lessons learned10.1016/S1473-3099(22)00434-0 ↗
5. Texture of microbial sediments revealed by cryo-scanning electron microscopy
6. Recent advances in genomic DNA sequencing of microbial species from single cells10.1038/nrg3785 ↗
7. Antibacterial resistance worldwide: causes, challenges and responses10.1038/nm1145 ↗
8. Antibiotics: past, present and future10.1016/j.mib.2019.10.008 ↗
9. Fluorescent probes for sensing and imaging within specific cellular organelles10.1021/acs.accounts.6b00292 ↗
10. Birks · 1970
11. Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole10.1039/b105159h ↗
12. Aggregation-induced emission: together we shine, united we soar!10.1021/acs.chemrev.5b00263 ↗
13. Aggregation-induced emission: new vistas at the aggregate level10.1002/anie.201916729 ↗
14. Recent advances of aggregation-induced emission materials for fluorescence image-guided surgery10.1016/j.biomaterials.2022.121709 ↗
15. Aggregation-enhanced theranostics: AIE sparkles in biomedical field10.1002/agt2.7 ↗
16. Aggregation-induced emission-based platforms for the treatment of bacteria, fungi, and viruses10.1002/adhm.202100736 ↗
17. Aggregation-induced fluorogens in bio-detection, tumor imaging, and therapy: a review10.31635/ccschem.021.202101307 ↗
18. Molecular mechanism of aggregation-induced emission10.1002/agt2.91 ↗
19. Deciphering the working mechanism of aggregation-induced emission of tetraphenylethylene derivatives by ultrafast spectroscopy10.1039/C8SC01170B ↗
20. Non-aromatic annulene-based aggregation-induced emission system via aromaticity reversal process10.1038/s41467-019-10818-5 ↗
21. Precise and long-term tracking of mitochondria in neurons using a bioconjugatable and photostable AIE luminogen10.1039/D1SC06336G ↗
22. Two-photon AIE bio-probe with large stokes shift for specific imaging of lipid droplets10.1039/C7SC01400G ↗
23. Fluorescent sensors based on aggregation-induced emission: recent advances and perspectives10.1021/acssensors.7b00551 ↗
24. A photostable AIE luminogen for specific mitochondrial imaging and tracking10.1021/ja310324q ↗
25. AIE bioconjugates for biomedical applications10.1002/adom.202000162 ↗
26. Recent advances of AIE light-up probes for photodynamic therapy10.1039/D1SC00045D ↗
27. Progress and trends of photodynamic therapy: from traditional photosensitizers to AIE-based photosensitizers10.1016/j.pdpdt.2021.102254 ↗
28. Aggregation-induced emission: recent advances in materials and biomedical applications10.1002/anie.202000845 ↗
29. Design of superior phototheranostic agents guided by Jablonski diagrams10.1039/D0CS00671H ↗
30. Characterization of electronic transitions in complex molecules10.1039/df9500900014 ↗
31. AIE luminogens for bioimaging and theranostics: from organelles to animals10.1016/j.chempr.2017.05.010 ↗
32. Precise molecular design for high-performance luminogens with aggregation-induced emission10.1002/adma.201903530 ↗
33. Photothermal agents based on small organic fluorophores with intramolecular motion10.1016/j.actbio.2022.07.004 ↗
34. Molecular engineering to boost AIE-active free radical photogenerators and enable high-performance photodynamic therapy under hypoxia10.1002/adfm.202002057 ↗
35. Aggregation-induced emission photosensitizers: from molecular design to photodynamic therapy10.1021/acs.jmedchem.9b02014 ↗
36. Tuning organelle specificity and photodynamic therapy efficiency by molecular function design10.1021/acsnano.9b04430 ↗
37. What are bacterial species?10.1146/annurev.micro.56.012302.160634 ↗
38. Specific discrimination of gram-positive bacteria and direct visualization of its infection towards mammalian cells by a DPAN-based AIEgen10.1016/j.biomaterials.2018.09.019 ↗
39. The bacterial cell envelope10.1101/cshperspect.a000414 ↗
40. Killing G(+) or G(−) bacteria? The important role of molecular charge in AIE-active photosensitizers10.1002/smtd.202000046 ↗
41. Ultrafast discrimination of gram-positive bacteria and highly efficient photodynamic antibacterial therapy using near-infrared photosensitizer with aggregation-induced emission characteristics10.1016/j.biomaterials.2019.119582 ↗
42. Identification of a functionally unique family of penicillin-binding proteins10.1021/jacs.7b10170 ↗
43. Fluorogenic probes/inhibitors of beta-lactamase and their applications in drug-resistant bacteria10.1002/anie.202006635 ↗
44. A receptor-targeting AIE photosensitizer for selective bacterial killing and real-time monitoring of photodynamic therapy outcome10.1039/D2CC02230C ↗
45. A fluorogenic trehalose probe for tracking phagocytosed mycobacterium tuberculosis10.1021/jacs.0c07700 ↗
46. A simple approach to bioconjugation at diverse levels: metal-free click reactions of activated alkynes with native groups of biotargets without prefunctionalization
47. A clickable AIEgen for visualization of macrophage-microbe interaction10.1016/j.bios.2022.114614 ↗
48. Visualization and in situ ablation of intracellular bacterial pathogens through metabolic labeling10.1002/anie.201910187 ↗
49. Highly fluorescent and photostable probe for long-term bacterial viability assay based on aggregation-induced emission10.1002/adhm.201200475 ↗
50. Molecular diagnostics for the detection and characterization of microbial pathogens10.1086/519259 ↗
51. Diagnosis and treatment of invasive fungal infections: looking ahead10.1093/jac/dkz041 ↗
52. Molecular diagnostics of infectious diseases10.1093/clinchem/43.11.2021 ↗
53. Cationic conjugated polymers for discrimination of microbial pathogens10.1002/adma.201400636 ↗
54. Direct visualization of bactericidal action of cationic conjugated polyelectrolytes and oligomers10.1021/la2044569 ↗
55. One stone, three birds: one AIEgen with three colors for fast differentiation of three pathogens10.1039/D0SC00256A ↗
56. Engineering sensor arrays using aggregation-induced emission luminogens for pathogen identification10.1002/adfm.201805986 ↗
57. Emerging fungal pathogens10.1007/BF01963467 ↗
58. A global view on fungal infections in humans and animals: opportunistic infections and microsporidioses10.1111/jam.15032 ↗
59. Antifungal susceptibility testing: a primer for clinicians10.1002/phar.1146 ↗
60. Antifungal susceptibility testing: practical aspects and current challenges10.1128/CMR.14.4.643-658.2001 ↗
61. Effect of fluconazole on viability of Candida albicans over extended periods of time10.1128/AAC.40.11.2622 ↗
62. A rapid method of staining for fungus and monilial infection10.1038/jid.1952.60 ↗
63. A rapid and inexpensive viability assay for zoospores and zoosporangia of Batrachochytrium dendrobatidis10.1016/j.mimet.2019.105688 ↗
64. The fluorescent toolbox for assessing protein location and function10.1126/science.1124618 ↗
65. More is less: creation of pathogenic microbe-related theranostic oriented AIEgens10.1016/j.biomaterials.2021.120725 ↗
66. A dibenzothiophene core-based small-molecule AIE probe for wash-free and selective staining of lipid droplets in live mammalian and fungal cells10.1016/j.snb.2021.130128 ↗
67. One-step, rapid fluorescence sensing of fungal viability based on a bioprobe with aggregation-induced emission characteristics10.1039/C9QM00732F ↗
68. Rapid and high-throughput testing of antifungal susceptibility using an AIEgen-based analytical system10.1016/j.biomaterials.2022.121618 ↗
69. A rapid, sensitive, multiplexed assay for detection of viral nucleic acids using the FlowMetrix system10.1093/clinchem/44.9.2054 ↗
70. Rapid and real-time detection technologies for emerging viruses of biomedical importance10.1007/s12038-008-0079-7 ↗
71. Early detection of SARS-CoV-2 seroconversion in humans with aggregation-induced near-infrared emission nanoparticle-labeled lateral flow immunoassay10.1021/acsnano.1c01932 ↗
72. Ultrabright nanoparticle-labeled lateral flow immunoassay for detection of anti-SARS-CoV-2 neutralizing antibodies in human serum10.1016/j.biomaterials.2022.121694 ↗
73. Novel strategy to prepare fluorescent polymeric nanoparticles based on aggregation-induced emission via precipitation polymerization for fluorescent lateral flow assay10.1039/D0QM00998A ↗
74. Ultrasensitive virion immunoassay platform with dual-modality based on a multifunctional aggregation-induced emission luminogen10.1021/acsnano.8b05270 ↗
75. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding10.1016/S0140-6736(20)30251-8 ↗
76. Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection10.1016/j.cmi.2020.09.057 ↗
77. A new coronavirus associated with human respiratory disease in China10.1038/s41586-020-2008-3 ↗
78. Rapid one-step detection of viral particles using an aptamer-based thermophoretic assay10.1021/jacs.1c02929 ↗
79. A wearable AIEgen-based lateral flow test strip for rapid detection of SARS-CoV-2 RBD protein and N protein10.1016/j.xcrp.2022.100740 ↗
80. Organic photo-antimicrobials: principles, molecule design, and applications10.1021/jacs.1c08679 ↗
81. Organic photosensitizers for antimicrobial phototherapy10.1039/D1CS00647A ↗
82. A bifunctional aggregation-induced emission luminogen for monitoring and killing of multidrug-resistant bacteria10.1002/adfm.202213353 ↗
83. A NIR-II emissive polymer AIEgen for imaging-guided photothermal elimination of bacterial infection10.1016/j.biomaterials.2022.121579 ↗
84. Penicillin: the medicine with the greatest impact on therapeutic outcomes10.1007/s00253-011-3587-6 ↗
85. The crisis in antibiotic resistance10.1126/science.257.5073.1064 ↗
86. Antibiotic resistance10.1016/j.jiph.2016.08.007 ↗
87. Fluorescent antibiotics: new research tools to fight antibiotic resistance10.1016/j.tibtech.2018.01.004 ↗
88. The commercial antibiotics with inherent AIE feature: in situ visualization of antibiotic metabolism and specifically differentiation of bacterial species and broad-spectrum therapy10.1016/j.bioactmat.2022.11.002 ↗
89. AIE-active antibiotic photosensitizer with enhanced fluorescence in bacteria infected cells and better therapy effect toward drug-resistant bacteria10.1021/acsabm.2c00681 ↗
90. Design and synthesis of theranostic antibiotic nanodrugs that display enhanced antibacterial activity and luminescence10.1073/pnas.1708556114 ↗
91. Inspiration from nature: bioAIEgens for biomedical and sensing applications10.1016/j.biomaterials.2022.121712 ↗
92. Leveraging bacterial survival mechanism for targeting and photodynamic inactivation of bacterial biofilms with red natural AIEgen10.1016/j.xcrp.2022.100803 ↗
93. Antibacterial biomaterials for skin wound dressing10.1016/j.ajps.2022.01.001 ↗
94. Antibacterial biohybrid nanofibers for wound dressings10.1016/j.actbio.2020.02.022 ↗
95. In situ electrospinning of aggregation-induced emission nanofibrous dressing for wound healing10.1002/smtd.202101247 ↗
96. Photodynamic therapy: a new antimicrobial approach to infectious disease?10.1039/b311900a ↗
97. Evaluation of structure-function relationships of aggregation-induced emission luminogens for simultaneous dual applications of specific discrimination and efficient photodynamic killing of gram-positive bacteria10.1021/jacs.9b07162 ↗
98. Biomaterial-associated infection: locating the finish line in the race for the surface10.1126/scitranslmed.3004528 ↗
99. Evaluation of the anti-biofilm activities of bacterial cellulose-tannic acid-magnesium chloride composites using an in vitro multispecies biofilm model10.1093/rb/rbab054 ↗
100. Mechanisms of biofilm resistance to antimicrobial agents10.1016/S0966-842X(00)01913-2 ↗