Biomimetic apatite coatings on titanium coprecipitated with cephradine and salviae miltlorrhizae

Abstract Incorporation of antibiotics in the apatite coatings on titanium surface is an effective step for surgical infections of titanium implant. In this work, antibiotics cephradine and traditional Chinese medicine salviae miltlorrhizae (SM) were incorporated in the simulated body fluid (SBF). The apatite coatings were coprecipitated with cephradine and SM by a biomimetic method. The research showed that in the biomimetic coprecipitation process cephradine containing carboxylic groups were beneficial to the apatite coprecipitation. X‐ray diffraction patterns showed that cephradine had a positive effect on the crystal growth in terms of cystallinity. And also in the Fourier transformed infrared spectra, the organic groups corresponded with cephradine were also observed. However, little apatite formed on the titanium immersed in SBF with SM. Probably, SM was more absorbed on the surface when calcium and phosphate ions precipitated. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008