Biocompatibility and antibacterial activity studies of polyamidoamine (PAMAM) dendron, side chain dendritic oligourethane (SCDOU)

Abstract Cytotoxicity of both polyamidoamine dendritic diol (PAMAM) and side chain dendritic oligourethane (SCDOU) was studied through interaction with mammalian fibroblast cells (L929). Cell metabolic activity in the presence of dendritic polymers was measured using an MTT assay exhibiting significant cell viability. Additionally, the antibacterial activity of PAMAM dendron, SCDOU, as well as their silver‐doped structures was studied against Escherichia coli bacteria. The results showed that the silver‐doped structures attain high antibacterial activity. Formation of silver‐doped dendritic polymers was investigated from the UV‐visible plasmon absorption band of silver particles. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 71A: 1–5, 2004