The effect of hydroxyapatite nanoparticles on adipogenic differentiation of human mesenchymal stem cells
Source abstract
Abstract
Abstract Due to its excellent biocompatibility, nanosized hydroxyapatite (nHA) has drawn much attention for various applications in biomedical fields. There are growing concerns about its biosecurity; however, little is known about its effects on adipogenesis. In the present study, nHA with three different sizes were synthesized, and the in vitro effects of nHA on cell proliferation and adipogenic differentiation of human mesenchymal stem cells (hMSCs) were investigated. The results clearly show that nHA does not affect the cell viability, the lipids droplets formation, triglyceride (TG) synthesis, and the expression of adipogenic marker genes/proteins of hMSCs at concentrations lower than 50 μg/mL. It is concluded that the adipogenic differentiation potential of hMSCs is not affected by nHA at noncytotoxic concentrations. These will provide a reference for the applications of nHA in biomedical fields. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1822–1831, 2018.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications · biodegradable polymer synthesis and properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering Tsinghua University Beijing 100084 China
Department of Stomatology Shengli Oilfield Central Hospital Dongying 257034 China
Graduate School at Shenzhen, Tsinghua University Shenzhen 518055 China
Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and Engineering, Tsinghua University Beijing 100084 China
Funding
National Natural Science Foundation of China
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