Benefits of 3D and 4D printing in recent biomedical applications: a review of rapid advances in additive manufacturing
Source abstract
Abstract
Purpose This review aims to provide a comprehensive assessment of the major benefits of 3D and 4D printing technologies in biomedical applications. It highlights their growing influence on personalized medicine, prosthetics, orthopedics, pharmaceuticals and cardiovascular treatments, while clarifying the practical, economic and societal implications of these emerging technologies. Design/methodology/approach Recent developments in additive manufacturing from 2018 to 2025 were analyzed through a critical and comparative review of scientific literature and industrial advancements. The methodology focuses on identifying key innovations, evaluating their clinical relevance and examining implementation challenges related to materials, biocompatibility and regulatory compliance. Findings The review demonstrates that 3D and 4D printing significantly enhance treatment efficiency, enable patient-specific customization and improve clinical outcomes through advanced materials and adaptive functionalities. Notable examples include self-expanding hydrogel stents, smart bone implants, biodegradable programmable sutures, shape-changing scaffolds and stimuli-responsive drug delivery systems. Remaining obstacles include material limitations, biocompatibility concerns and stringent regulations surrounding bio printing. Originality/value This paper provides an updated synthesis covering the most recent decade of progress, integrating advances not addressed in earlier reviews. Its unique contribution lies in emphasizing both the technological innovations and their practical translation into clinical contexts, demonstrating the transformative potential of 3D/4D printing for future healthcare solutions.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Advanced Materials and Mechanics · Additive Manufacturing and 3D Printing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
University of Tunis Laboratory of Mechanical, Production, and Energy Engineering (LMPE), National Engineering School of Tunis (ENSIT), , Tunis,
University of Monastir Mechanical Engineering Laboratory (LGM), National Engineering School of Monastir (ENIM), , Monastir,
University of Tunis Laboratory of Mechanical, Production, and Energy Engineering (LMPE), National Engineering School of Tunis (ENSIT), , Tunis, , and
Imam Mohammad Ibn Saud Islamic University Mechanical Engineering Department, , Riyadh,
References (100+)
Show source-provided references
1. A review of natural Fiber-Based filaments for 3D printing: filament fabrication and characterization10.3390/ma16114052 ↗
2. 22-Emission spectroscopy, comprehensive polymer science and supplements
3. Effect of UV-C radiation on 3D printed ABS-PC polymers10.3390/polym15081966 ↗
4. 4D printing with mechanically robust, thermally actuating hydrogels10.1002/marc.201500079 ↗
5. 3D printing in the education of graphic engineering and design students
6. 4D printing of shape memory polylactic acid (PLA) components: investigating the role of the operational parameters in fused deposition modelling (FDM)10.1016/j.jmapro.2020.11.036 ↗
7. Structure–property relationships for 3D-printed PEEK intervertebral lumbar cages produced using fused filament fabrication10.1557/jmr.2018.178 ↗
8. 4D printing of composite thermoplastic elastomers for super-stretchable soft artificial muscles10.1002/app.57177 ↗
9. 3-D printing: the new industrial revolution10.1016/j.bushor.2011.11.003 ↗
10. Blum · 2017
11. Bouffaron · 2014
12. Additive manufacturing: rapid prototyping comes of age10.1108/13552541211231563 ↗
13. Campbell · 2011 · 1
14. The programmable world10.1038/scientificamerican1114-60 ↗
15. Fused deposition modeling with polypropylene10.1016/j.matdes.2015.06.053 ↗
16. Caron · 2022
17. 4D printing of high performance shape memory polymer using stereolithography10.1016/j.matdes.2017.04.049 ↗
18. 3D bioprinting for organ regeneration10.1002/adhm.201601118 ↗
19. A comprehensive review on additive manufacturing of medical devices10.1007/s40964-021-00188-0 ↗
20. Double network shape memory hydrogels activated by near-infrared with high mechanical toughness, nontoxicity, and 3D printability10.1016/j.cej.2018.09.078 ↗
21. Dammak · 2022
22. Effects of nozzle temperature and building orientation on mechanical properties and microstructure of PEEK and PEI printed by 3D-FDM10.1016/j.polymertesting.2019.105948 ↗
23. Applications of 3d-printed peek via fused filament fabrication: a systematic review10.3390/polym13224046 ↗
24. Preparation of poly (ε-caprolactone)-based tissue engineering scaffolds by stereolithography10.1016/j.actbio.2011.06.039 ↗
25. The role of three-dimensional printing in healthcare and medicine10.1016/j.matdes.2020.108940 ↗
26. Near-infrared absorbing dyes10.1021/cr00014a003 ↗
27. High-performance nylon-6 sustainable filaments for additive manufacturing10.3390/ma12233955 ↗
28. A hyaluronic acid/PVA electrospun coating on 3D printed PLA scaffold for orthopedic application10.1007/s40204-022-00180-z ↗
29. Effect of print parameters on additive manufacturing of metallic parts: performance and sustainability aspects10.1038/s41598-022-22613-2 ↗
30. Fouassier · 201210.1002/9783527648245 ↗
31. A peptide from human semenogelin I self-assembles into a pH-responsive hydrogel10.1039/C4SM01793E ↗
32. Axial crushing of nylon and Al/nylon hybrid tubes by FDM 3D printing10.1016/j.compstruct.2020.113055 ↗
33. Multimaterial 4D printing with tailorable shape memory polymers10.1038/srep31110 ↗
34. Active materials by four-dimension printing10.1063/1.4819837 ↗
35. Gross · 201410.1021/ac403397r ↗
36. Printability and tensile performance of 3D printed polyethylene terephthalate glycol using fused deposition modelling10.3390/polym11071220 ↗
37. Additive manufacturing: technology, applications and research needs10.1007/s11465-013-0248-8 ↗
38. 4D printing and its applications in orthopaedics10.1016/j.jcot.2018.08.016 ↗
39. Piezoresistive properties of 3D-Printed polylactic acid (PLA) nanocomposites10.3390/polym14152981 ↗
40. Digital additive manufacturing: from rapid prototyping to rapid manufacturing
41. A Graphene-Based bimorph structure for design of high performance photoactuators10.1002/adma.201502777 ↗
42. The effect of different processing, injection molding (IM) and fused deposition modeling (FDM), on the environmental stress cracking (ESC) behavior of filled and unfilled polycarbonate (PC)10.3144/expresspolymlett.2021.18 ↗
43. Hull · Apparatus for Production of Three-Dimensional Objects by Stereolithography. US Pat · 1986 · 4 · 1
44. Polymer 4D printing: advanced shape-change and beyond10.1002/pol.20210718 ↗
45. Bio-origami hydrogel scaffolds composed of photocrosslinked PEG bilayers10.1002/adhm.201200458 ↗
46. Programming the shape-shifting of flat soft matter: from self-rolling/self-twisting materials to self-folding origami10.1039/C6MH00195E ↗
47. 3D bioprinting strategies for the regeneration of functional tubular tissues and organs10.3390/bioengineering7020032 ↗
48. Nanoparticle–hydrogel superstructures for biomedical applications10.1016/j.jconrel.2020.05.041 ↗
49. Various FDM mechanisms used in the fabrication of continuous-fiber reinforced composites: a review10.3390/polym16060831 ↗
50. 3D printing of smart materials: a review on recent progresses in 4D printing10.1080/17452759.2015.1097054 ↗
51. 4D biofabrication using shape-morphing hydrogels10.1002/adma.201703443 ↗
52. Self-healing mussel-inspired multi-pH-responsive hydrogels10.1021/bm301844u ↗
53. Kulish · 2022
54. Strain sensing behavior of FDM 3D printed carbon black filled TPU with periodic configurations and flexible substrates10.1016/j.jmapro.2021.12.020 ↗
55. Model development and numerical simulation of electric-stimulus-responsive hydrogels subject to an externally applied electric field10.1016/j.bios.2003.10.004 ↗
56. Fast-moving soft electronic fish10.1126/sciadv.1602045 ↗
57. Optimization of tensile strength and processing time using Pcr-Topsis method for FDM process
58. 4D printing of mechanically robust PLA/TPU/Fe3O4 magneto-responsive shape memory polymers for smart structures10.1016/j.compositesb.2022.110382 ↗
59. Nanomaterials reinforced polymer filament for fused deposition modeling: a state-of-the-art review10.3390/polym15142980 ↗
60. Thermoplastic polycaprolactone elastomer for a 3D-printed pericardial scaffold in the treatment of dilated cardiomyopathy10.1016/j.bprint.2022.e00252 ↗
61. Electric field-induced aligned multi-wall carbon nanotube networks in epoxy composites10.1016/j.polymer.2004.11.081 ↗
62. 3D printing of high-strength aluminium alloys10.1038/nature23894 ↗
63. Effects of electron beam irradiation on 3D-printed biopolymers for bone tissue engineering10.3390/jcs5070182 ↗
64. Mastalerz, C. (2021), “Impression 4D de polymères pour la santé”, Doctoral dissertation, (SantePolym4D), Reims.
65. Selective laser sintering in biomedical engineering10.1007/s11517-012-1001-x ↗
66. Application of optical digitizing techniques to evaluate the shape accuracy of anatomical models derived from computed tomography data10.1016/j.joms.2005.11.083 ↗
67. A poly (D, L-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography10.1016/j.biomaterials.2009.03.055 ↗
68. A review on stereolithography and its applications in biomedical engineering10.1016/j.biomaterials.2010.04.050 ↗
69. An advanced multifunctional hydrogel-based dressing for wound monitoring and drug delivery10.1002/adhm.201700718 ↗
70. 3D and 4D printing of PETG–ABS–Fe3O4 nanocomposites with supreme remotely driven magneto-thermal shape-memory performance10.3390/polym16101398 ↗
71. Soft material for soft actuators10.1038/s41467-017-00685-3 ↗
72. Optimization of fused deposition modeling process parameters: a review of current research and future prospects10.1007/s40436-014-0097-7 ↗
73. Initiation of shape-memory effect by inductive heating of magnetic nanoparticles in thermoplastic polymers10.1073/pnas.0600079103 ↗
74. Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients10.1126/scitranslmed.3010825 ↗
75. Responsive cellulose-hydrogel composite ink for 4D printing10.1016/j.matdes.2018.09.009 ↗
76. A metallographic review of 3D printing/additive manufacturing of metal and alloy products and components10.1007/s13632-018-0433-6 ↗
77. Three-dimensional printing of pH-responsive and functional polymers on an affordable desktop printer10.1021/acsami.6b07388 ↗
78. Channelling quality for moulded parts using fast manufacturing10.1016/S0026-0657(09)70201-2 ↗
79. 4D printing prospects for the aerospace industry: a critical review10.1016/j.promfg.2018.11.016 ↗
80. Additive manufacturing in construction: a review on technologies, processes, materials, and their applications of 3D and 4D printing10.1002/mdp2.253 ↗
81. A review on additive manufacturing of polymer-fiber composites10.1016/j.compstruct.2017.08.088 ↗
82. Comparison of prosthetic models produced by traditional and additive manufacturing methods10.4047/jap.2015.7.4.294 ↗
83. 4D printing: dawn of an emerging technology cycle10.1108/AA-07-2014-062 ↗
84. A comparison of traditional manufacturing vs additive manufacturing, the best method for the job10.1016/j.promfg.2019.02.003 ↗
85. 3D printing of fiber-reinforced plastic composites using fused deposition modeling: a status review10.3390/ma14164520 ↗
86. Synthesis and characterization of pH-responsive nanoscale hydrogels for oral delivery of hydrophobic therapeutics10.1016/j.ejpb.2016.09.007 ↗
87. Poly (ethylene terephthalate) glycol/carbon black composites for 4D printing10.1016/j.matchemphys.2024.129737 ↗
88. 4D printing of polyethylene glycol-grafted carbon nanotube-reinforced polyvinyl chloride–polycaprolactone composites for enhanced shape recovery and thermomechanical performance10.1002/aisy.202500113 ↗
89. 4D printing thermo-magneto-responsive PETG-Fe3O4 nanocomposites with enhanced shape memory effects10.1016/j.apmt.2024.102361 ↗
90. Shape memory performance assessment of FDM 3D printed PLA-TPU composites by Box-Behnken response surface methodology10.1007/s00170-023-11571-2 ↗
91. Advancing sustainable shape memory polymers through 4D printing of polylactic acid-polybutylene adipate terephthalate blends10.1016/j.eurpolymj.2024.113289 ↗
92. 4D printing for automotive industry applications
93. Metal FDM, a new extrusion-based additive manufacturing technology for manufacturing of metallic parts: a review10.1007/s40964-021-00250-x ↗
94. Ruthenium phthalocyanine and naphthalocyanine complexes: synthesis, properties and applications10.1016/j.ccr.2006.09.011 ↗
95. 3D printing based on imaging data: review of medical applications10.1007/s11548-010-0476-x ↗
96. Additive manufacturing of polyether ether ketone (PEEK) for space applications: a nanosat polymeric structure10.3390/polym13010011 ↗
97. Electromagnetic activation of shape memory polymer networks containing magnetic nanoparticles10.1002/marc.200600225 ↗
98. Preparation of polypropylene/short glass fiber composite as fused deposition modeling (FDM) filament10.1016/j.rinp.2018.11.065 ↗
99. Optimizing selective laser sintering process by grey relational analysis and soft computing techniques10.1016/j.ijleo.2018.08.040 ↗
100. A review on the various processing parameters in FDM