journal article·2006-09

Novel alginate–acrylic polymers as a platform for drug delivery

Paola Laurienzo, Mario Malinconico, Giuditta Mattia, Roberto Russo, M.I. La Rotonda, Fabiana Quaglia, Donatella Capitani, Luisa Mannina

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Abstract

Abstract The aim of the present work was to develop a family of novel materials based on a combination of sodium alginate and acrylic polymers and to evaluate their potential in drug delivery applications. In the presence of sodium alginate, acrylic chains with acidic as well as basic moieties were polymerized to create an interpolymer complex based on electrostatic interactions that are able to modulate the release rate of low molecular weight drugs. The synthesized materials were used to prepare hydrophilic matrices for drug delivery and tested for their adhesion properties to glass, used as a model substrate for mucoadhesion. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006
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Research context

OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Drug Delivery Systems · Microfluidic and Capillary Electrophoresis Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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