Aspects of the in vitro bioactivity of hydraulic calcium (alumino)silicate cement

Abstract In response to a burgeoning interest in the prospective clinical applications of hydraulic calcium (alumino)silicate cements, the in vitro bioactivity and dissolution characteristics of a white Portland cement have been investigated. The formation of an apatite layer within 6 h of contact with simulated body fluid was attributed to the rapid dissolution of calcium hydroxide from the cement matrix and to the abundance of pre‐existing SiOH nucleation sites presented by the calcium silicate hydrate phase. A simple kinetic model has been used to describe the rate of apatite formation and an apparent pseudo‐second‐order rate constant for the removal of HPO₄²⁻ ions from solution has been calculated (k₂ = 5.8 ×10⁻⁴ g mg⁻¹ min⁻¹). Aspects of the chemistry of hydraulic cements are also discussed with respect to their potential use in the remedial treatment of living tissue. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009