DataVXJournal of Biomedical Materials Research Part APaper
journal article·2019-10

Development of bone regeneration strategies using human periosteum‐derived osteoblasts and oxygen‐releasing microparticles in mandibular osteomyelitis model of miniature pig

Sun‐Chul Hwang, Dae Seok Hwang, Ho Yong Kim, Min Ji Kim, Young‐Hoon Kang, Sung‐Hoon Byun, Gyu‐Jin Rho, Hyeon‐Jeong Lee, Hee‐Chun Lee, Sang‐Hyun Kim, Seung Chul Baik, Jin‐Sik Park, Se Heang Oh, June‐Ho Byun

Journal of Biomedical Materials Research Part A· Volume 107· Issue 10
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Source abstract

Abstract

ABSTRACT Hypoxia and limited vascularization inhibit bone growth and recovery after surgical debridement to treat osteomyelitis. Similarly, despite significant efforts to create functional tissue‐engineered organs, clinical success is often hindered by insufficient oxygen diffusion and poor vascularization. To overcome these shortcomings, we previously used the oxygen carrier perfluorooctane (PFO) to develop PFO emulsion‐loaded hollow microparticles (PFO‐HPs). PFO‐HPs act as a local oxygen source that increase cell viability and maintains the osteogenic differentiation potency of human periosteum‐derived cells (hPDCs) under hypoxic conditions. In the present study, we used a miniature pig model of mandibular osteomyelitis to investigate bone regeneration using hPDCs seeded on PFO‐HPs (hPDCs/PFO‐HP) or hPDCs seeded on phosphate‐buffered saline (PBS)‐HPs (hPDCs/PBS‐HP). Osteomyelitis is characterized by a series of microbial invasion, vascular disruption, bony necrosis, and sequestrum formation due to impaired host defense response. Sequential plain radiography, computed tomography (CT), and 3D reconstructed CT images revealed new bone formation was more advanced in defects that had been implanted with the hPDCs/PFO‐HPs than in defects implanted with the hPDCs/PBS‐HP. Thus, PFO‐HPs are a promising tissue engineering approach to repair challenging bone defects and regenerate structurally organized bone tissue with 3D architecture.
Source: crossref · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Orthopedic Infections and Treatments · Osteomyelitis and Bone Disorders Research · Infective Endocarditis Diagnosis and Management

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopaedic Surgery Institute of Health Sciences, School of Medicine, Gyeongsang National University Jinju Republic of Korea

Department of Oral and Maxillofacial Surgery School of Dentistry, Pusan National University and Pusan National University Dental Hospital Yangsan Republic of Korea

Department of Nanobiomedical Science Dankook University Cheonan Republic of Korea

Department of Oral and Maxillofacial Surgery Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Institute of Health Sciences, Gyeongsang National University Jinju Republic of Korea

The Korean Society of Maxillofacial Aesthetic Surgery Seoul Republic of Korea

Department of Theriogenology and Biotechnology College of Veterinary Medicine, Gyeongsang National University Jinju Republic of Korea

Department of Veterinary Medical Imaging College of Veterinary Medicine, Gyeongsang National University Jinju Republic of Korea

Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University Jinju Republic of Korea

Department of Microbiology Gyeongsang National University School of Medicine, Institute of Health Sciences Jinju Republic of Korea

Funding

Ministry of Education, Science and Technology · Ministry of Health and Welfare

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