journal article·2025-09-29

SERS Spectral Monitoring of Oxytetracycline In-Vitro Pharmacokinetics Quantification from Antibacterial Stimuli Responsive PVA/AgO Nanobiocomposite Hydrogel Along with Multivariate Data Analysis Techniques

Nasir Mehmood, Anfal Fatima, Abdul Naman, Salah Knani, Sobia Younas

Plasmonics· Volume 21· Issue 1
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OpenAlex topics: Spectroscopy Techniques in Biomedical and Chemical Research · Biosensors and Analytical Detection · Advanced Drug Delivery Systems

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References (100+)

Show source-provided references
1. Pickens LB, Tang Y (2010) Oxytetracycline biosynthesis. J Biol Chem 285(36):27509–2751510.1074/jbc.R110.130419 ↗
2. Gandova V et al (2023) Comparative analysis of antibacterial activity and physicochemical properties of peppermint and cornmint essential oils and their main compound menthol. J Chem Technol Metall 58(4):664–67110.59957/jctm.v58i4.99 ↗
3. Kalpana J, Srinivas M (2023) Coordination compounds in biology and medicine. 24th & 25th Feb, p 25
4. Li Z-J et al (2019) Degradation mechanisms of oxytetracycline in the environment. J Integr Agric 18(9):1953–196010.1016/S2095-3119(18)62121-5 ↗
5. Aflori M (2021) Smart nanomaterials for biomedical applications—a review. Nanomaterials 11(2):39610.3390/nano11020396 ↗
6. Alfadul SM et al (2023) Metal-based anticancer complexes and p53: how much do we know? Cancers (Basel) 15(10):283410.3390/cancers15102834 ↗
7. Li D et al (2008) Determination and fate of oxytetracycline and related compounds in oxytetracycline production wastewater and the receiving river. Environ Toxicol Chem 27(1):80–8610.1897/07-080.1 ↗
8. Anandabaskar N (2021) Protein synthesis inhibitors. Introduction to basics of pharmacology and toxicology: volume 2: essentials of systemic pharmacology: from principles to practice. Springer, pp 835–86810.1007/978-981-33-6009-9_55 ↗
9. Last JA (1965) Studies on the mechanism of action of oxytetracycline on E. coli. The Ohio State University
10. AL-Azzawi MK, Hasan NA, Barrak MM (2024) A review of the development of an understanding of antibiotic interactions, from mechanisms of action to novel resistance and the search for natural alternatives. Journal of Medical Genetics and Clinical Biology 1(6):78–10210.61796/jmgcb.v1i6.585 ↗
11. Elmaidomy AH et al (2022) Antimicrobial potentials of natural products against multidrug resistance pathogens: a comprehensive review. RSC Adv 12(45):29078–2910210.1039/D2RA04884A ↗
12. Naman A et al (2025) Spectinomycin-loaded antibacterial polyvinyl alcohol/silver oxide nanobiocomposite hydrogel: synthesis, characterization, swelling, cytotoxicity, and controlled drug release carrier. BioNanoScience 15(2):1–1610.1007/s12668-025-01943-1 ↗
13. Cheng S et al (2025) A motion-responsive injectable lubricative hydrogel for efficient Achilles tendon adhesion prevention. Mater Today Bio 30:10145810.1016/j.mtbio.2025.101458 ↗
14. Costa AM, Mano JF (2015) Extremely strong and tough hydrogels as prospective candidates for tissue repair–a review. Eur Polym J 72:344–36410.1016/j.eurpolymj.2015.07.053 ↗
15. Bashir S et al (2020) Fundamental concepts of hydrogels: synthesis, properties, and their applications. Polymers 12(11):270210.3390/polym12112702 ↗
16. Andrade F et al (2021) Stimuli-responsive hydrogels for cancer treatment: the role of pH, light, ionic strength and magnetic field. Cancers (Basel) 13(5):116410.3390/cancers13051164 ↗
17. Liu Y, Zhang J, Wang D (2025) Preparation schemes and applications of multifunctional PVA composite hydrogels. Chem Eng J. https://doi.org/10.1016/j.cej.2025.16094610.1016/j.cej.2025.160946 ↗
18. Rezaee S et al (2025) Challenges and opportunities for incorporating physiological information into pharmacokinetic models of intranasal drug delivery to the brain: a review of the current status and future trajectories. Mol Pharm. https://doi.org/10.1021/acs.molpharmaceut.5c0029710.1021/acs.molpharmaceut.5c00297 ↗
19. Varnekar S et al (2025) Physiologically based pharmacokinetic (PBPK) modeling and pharmacokinetic pharmacodynamic (PKPD) modelling. Applications of computational tools in drug design and development. Springer, pp 475–51510.1007/978-981-96-4154-3_14 ↗
20. Liu Z et al (2024) Classification of three anesthesia stages based on near-infrared spectroscopy signals. IEEE J Biomed Health Inform 28(9):5270–527910.1109/JBHI.2024.3409163 ↗
21. Mohite P et al (2025) Meticulous standards for bio-relevant method development and validation of in vitro release testing for regenerative topicals: a comprehensive review. Regen Eng Transl Med, pp 1–2210.1007/s40883-025-00389-x ↗
22. Patel SK et al (2025) Optimizing Irbesartan fast dissolving tablets using natural polysaccharides for enhanced drug delivery and patient compliance. Int Res J Multidiscip Scope 6(1):1181–119010.47857/irjms.2025.v06i01.02542 ↗
23. Serrano ACCL et al (2025) The use of design of experiments (DoE) approaches for the development of self-emulsifying drug delivery systems (SEDDS). Applied Nano 6(1):410.3390/applnano6010004 ↗
24. Zheng Y et al (2025) Thermosensitive hydrogel as an injectable aggregation-induced emission photosensitizer delivery scaffold for lung cancer therapeutics with long-acting photodynamic therapy. Dyes Pigments. https://doi.org/10.1016/j.dyepig.2025.11296610.1016/j.dyepig.2025.112966 ↗
25. Naman A et al (2024) Surface-enhanced raman spectroscopy for characterization of supernatant samples of biofilm forming bacterial strains. Spectrochim Acta A Mol Biomol Spectrosc 305:12341410.1016/j.saa.2023.123414 ↗
26. Mehmood N et al (2024) Surface-enhanced raman spectroscopy for the characterization of bacterial pellets of Staphylococcus aureus infected by bacteriophage. RSC Adv 14(8):5425–543410.1039/D3RA07575C ↗
27. Smith E, Dent G (2019) Modern Raman spectroscopy: a practical approach. John Wiley & Sons10.1002/9781119440598 ↗
28. Dent G (1996) Modern Raman spectroscopy a practical approach
29. Ali A et al (2024) Quantitative analysis of solid dosage forms of Atenolol by Raman spectroscopy. Drug Dev Ind Pharm 50(7):619–62710.1080/03639045.2024.2377331 ↗
30. Meraj L et al (2023) Characterization of structural changes occurring in insulin at different time intervals at room temperature by surface-enhanced Raman spectroscopy. Photodiagn Photodyn Ther 44:10379610.1016/j.pdpdt.2023.103796 ↗
31. Gao Y et al (2022) Dual signal light detection of beta-lactoglobulin based on a porous silicon bragg mirror. Biosens Bioelectron 204:11403510.1016/j.bios.2022.114035 ↗
32. Shahbaz M et al (2023) Qualitative and quantitative analysis of azithromycin as solid dosage by raman spectroscopy. ACS Omega 8(39):36393–3640010.1021/acsomega.3c05245 ↗
33. Anwar M et al (2024) Rapid identification and quantification of adulteration in methyl eugenol using Raman spectroscopy coupled with multivariate data analysis. ACS Omega 9(7):7545–7553
34. Zhang B et al (2025) AuNPs/C-CNF/PVA hydrogel SERS sensor for comprehensive detection of antitumor drug separation and enrichment. Chem Eng J. https://doi.org/10.1016/j.cej.2025.16428210.1016/j.cej.2025.164282 ↗
35. Hammad QK, Ayyash AN, Mutlak FA-H (2023) Improving SERS substrates with Au/Ag-coated Si nanostructures generated by laser ablation synthesis in PVA. J Opt 52(3):1528–153610.1007/s12596-022-00971-4 ↗
36. Zhang X et al (2024) Bioinspired flexible kevlar/hydrogel composites with antipuncture and strain-sensing properties for personal protective equipment. ACS Appl Mater Interfaces 16(34):45473–4548610.1021/acsami.4c08659 ↗
37. Fá AG et al (2019) Detection of oxytetracycline in honey using SERS on silver nanoparticles. TRAC Trends Anal Chem 121:11567310.1016/j.trac.2019.115673 ↗
38. Lee K-M et al (2020) Rapid detection and prediction of chlortetracycline and oxytetracycline in animal feed using surface-enhanced Raman spectroscopy (SERS). Food Control 114:10724310.1016/j.foodcont.2020.107243 ↗
39. Kiszkiel-Taudul I, Skorupska M (2025) Chromatographic determination of oxytetracycline in milk product samples using liquid-liquid microextraction procedure. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 42(1):12–2110.1080/19440049.2024.2430277 ↗
40. Xing C et al (2020) A highly selective fluorescent probe for Al3+ based on bis (2-hydroxy-1-naphthaldehyde) oxaloyldihydrazone with aggregation-induced emission enhancement and gel properties. Spectrochim Acta A Mol Biomol Spectrosc 224:11740610.1016/j.saa.2019.117406 ↗
41. Kowalski C, Pomorska M, Sławik T (2006) Development of HPLC with UV-VIS detection for the determination of the level of oxytetracycline in the biological matrix. J Liq Chromatogr Relat Technol 29(18):2721–273110.1080/10826070600925030 ↗
42. Liang A et al (2021) A new covalent organic framework of dicyandiamide-benzaldehyde nanocatalytic amplification SERS/RRS aptamer assay for ultratrace oxytetracycline with the nanogold indicator reaction of polyethylene glycol 600. Biosensors 11(11):45810.3390/bios11110458 ↗
43. Wu Z (2019) AuNP tetramer-based aptasensor for SERS sensing of oxytetracycline. Food Anal Methods 12(5):1121–112710.1007/s12161-019-01453-3 ↗
44. Ma Y et al (2023) A portable sensor for glucose detection in Huangshui based on blossom-shaped bimetallic organic framework loaded with silver nanoparticles combined with machine learning. Food Chem 429:13685010.1016/j.foodchem.2023.136850 ↗
45. Jolliffe IT, Cadima J (2016) Principal component analysis: a review and recent developments. Philos Trans R Soc Lond A Math Phys Eng Sci 374(2065):20150202
46. Parveen A et al (2025) SERS spectral monitoring of low molecular weight fractions of blood serum samples of myocardial infarction patients using a 50 kDa device along with multivariate data analysis techniques. Plasmonics, pp 1–1210.1007/s11468-025-02883-y ↗
47. Malashin I et al (2025) Support vector machines in polymer science: a review. Polymers 17(4):49110.3390/polym17040491 ↗
48. Fan H et al (2021) An operating performance assessment strategy with multiple modes based on least squares support vector machines for drilling process. Comput Ind Eng 159:10749210.1016/j.cie.2021.107492 ↗
49. Wang J et al (2021) Insights into chemometric algorithms for quality attributes and hazards detection in foodstuffs using Raman/surface enhanced Raman spectroscopy. Compr Rev Food Sci Food Saf 20(3):2476–250710.1111/1541-4337.12741 ↗
50. Shi G et al (2022) Kernel principal component analysis and differential non-linear feature extraction of pesticide residues on fruit surface based on surface-enhanced Raman spectroscopy. Front Plant Sci 13:95677810.3389/fpls.2022.956778 ↗
51. Yadav A et al (2025) Implementing partial least squares and machine learning regressive models for prediction of drug release in targeted drug delivery application. Sci Rep 15(1):2246110.1038/s41598-025-06227-y ↗
52. Caneschi A et al (2023) The use of antibiotics and antimicrobial resistance in veterinary medicine, a complex phenomenon: a narrative review. Antibiotics 12(3):48710.3390/antibiotics12030487 ↗
53. Manyi-Loh C et al (2018) Antibiotic use in agriculture and its consequential resistance in environmental sources: potential public health implications. Molecules 23(4):79510.3390/molecules23040795 ↗
54. Mog M et al (2020) Problems of antibiotic resistance associated with oxytetracycline use in aquaculture: a review. J Entomol Zool Stud 8:1075–1082
55. Kounatidis D et al (2024) Third-generation tetracyclines: current knowledge and therapeutic potential. Biomolecules 14(7):78310.3390/biom14070783 ↗
56. Gao P et al (2025) An optimized SPE‐UPLC–MS/MS method for simultaneous quantification of 11 tetracyclines in dairy products. J Sci Food Agric
57. Shahzad K et al (2022) Classification of tuberculosis by surface-enhanced raman spectroscopy (SERS) with principal component analysis (PCA) and partial least squares–discriminant analysis (PLS-DA). Anal Lett 55(11):1731–174410.1080/00032719.2021.2024218 ↗
58. Ahmadian Y et al (2019) Synthesis of polyvinyl alcohol/CuO nanocomposite hydrogel and its application as drug delivery agent. Polym Bull 76:1967–198310.1007/s00289-018-2477-9 ↗
59. Bakravi A et al (2018) Synthesis of gelatin-based biodegradable hydrogel nanocomposite and their application as drug delivery agent. Adv Polym Technol 37(7):2625–263510.1002/adv.21938 ↗
60. Yousef T, Hassan N (2017) Supramolecular encapsulation of doxorubicin with β-cyclodextrin dendrimer: in vitro evaluation of controlled release and cytotoxicity. J Incl Phenom Macrocycl Chem 87:105–11510.1007/s10847-016-0682-4 ↗
61. Tayeng D et al (2025) UV spectrophotometric method development and validation for the combined plant extract traditionally used in Arunachal Pradesh to treat malaria. J Neonatal Surg 14(30s):975–98310.63682/jns.v14i30S.7533 ↗
62. Janicki P, Erskine W, James M (1990) High-performance liquid chromatographic method for the direct determination of the volatile anaesthetics halothane, isoflurane and enflurane in water and in physiological buffer solutions. J Chromatogr A 518:250–25310.1016/S0021-9673(01)93183-8 ↗
63. Paul D (2011) Elaborations on the Higuchi model for drug delivery. Int J Pharm 418(1):13–1710.1016/j.ijpharm.2010.10.037 ↗
64. Hayashi T et al (2005) Formulation study and drug release mechanism of a new theophylline sustained-release preparation. Int J Pharm 304(1–2):91–10110.1016/j.ijpharm.2005.07.022 ↗
65. Corsaro C et al (2021) Weibull modeling of controlled drug release from Ag-PMA nanosystems. Polymers 13(17):289710.3390/polym13172897 ↗
66. Jafari S, Soleimani M, Badinezhad M (2022) Application of different mathematical models for further investigation of in vitro drug release mechanisms based on magnetic nano-composite. Polym Bull 79(2):1021–103810.1007/s00289-021-03537-9 ↗
67. Nawaz H et al (2010) Evaluation of the potential of Raman microspectroscopy for prediction of chemotherapeutic response to cisplatin in lung adenocarcinoma. Analyst 135(12):3070–307610.1039/c0an00541j ↗
68. Butler HJ et al (2018) Optimised spectral pre-processing for discrimination of biofluids via ATR-FTIR spectroscopy. Analyst 143(24):6121–613410.1039/C8AN01384E ↗
69. Samantaray S, Sahoo A (2022) Prediction of suspended sediment concentration using hybrid SVM-WOA approaches. Geocarto Int 37(19):5609–563510.1080/10106049.2021.1920638 ↗
70. Valkenborg D et al (2023) Support vector machines. Am J Orthod Dentofacial Orthop 164(5):754–75710.1016/j.ajodo.2023.08.003 ↗
71. Bajwa J et al (2020) Quantitative analysis of solid dosage forms of cefixime using Raman spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc 238:11844610.1016/j.saa.2020.118446 ↗
72. Mukherji S et al (2019) Synthesis and characterization of size-and shape-controlled silver nanoparticles. Phys Sci Rev 4(1):20170082
73. D'Agostino A (2017) Silver nanoparticles for antibacterial and pharmaceutical applications
74. Manimaran M et al (2025) Critical review on the stability and thermal conductivity of water-based hybrid nanofluids for heat transfer applications. RSC Adv 15(18):14088–1412510.1039/D5RA00844A ↗
75. Shrestha S, Wang B, Dutta P (2020) Nanoparticle processing: understanding and controlling aggregation. Adv Colloid Interface Sci 279:10216210.1016/j.cis.2020.102162 ↗
76. Velgosova O et al (2023) Preparation, structure, and properties of PVA–AgNPs nanocomposites. Polymers 15(2):37910.3390/polym15020379 ↗
77. Girgin A et al (2023) Colorimetric sensor based AgNPs for the detection of cyanide using UV-Vis spectrophotometry. ChemSelect 8(33):e202301663
78. Sholikhah UN et al (2020) Purification method of silver nanoparticles (AgNPs) and its identification using UV-Vis spectrophotometer. Key Eng Mater 840:484–49110.4028/www.scientific.net/KEM.840.484 ↗
79. Menichetti A et al (2023) Effect of size, shape and surface functionalization on the antibacterial activity of silver nanoparticles. J Funct Biomater 14(5):24410.3390/jfb14050244 ↗
80. De Veij M et al (2009) Reference database of raman spectra of pharmaceutical excipients. J Raman Spectrosc 40(3):297–30710.1002/jrs.2125 ↗
81. Chen X, Hu Y, Gao J (2013) Tautomers of 2-aminothiazole molecules in aqueous solutions explored by Raman, SERS and DFT methods. J Mol Struct 1049:362–36710.1016/j.molstruc.2013.06.041 ↗
82. Iliescu T, Baia M, Pavel I (2006) Raman and SERS investigations of potassium benzylpenicillin. J Raman Spectrosc 37(1–3):318–32510.1002/jrs.1464 ↗
83. Kure B, Morris MD (1976) Raman spectra of phenothiazine and some pharmaceutical derivatives. Talanta 23(5):398–40010.1016/0039-9140(76)80056-2 ↗
84. Bakkar MA et al (2021) Raman spectroscopy for the qualitative and quantitative analysis of solid dosage forms of Sitagliptin. Spectrochim Acta A Mol Biomol Spectrosc 245:11890010.1016/j.saa.2020.118900 ↗
85. Chen H-Y et al (2023) Detection of oxytetracycline on NH2–UiO-66 (Zr)@ Au NPs with high sensitivity and selectivity by SERS. J Phys Chem C Nanomater Interfaces 127(42):20779–2078510.1021/acs.jpcc.3c05339 ↗
86. Adomavičiūtė S, Velička M, Šablinskas V (2019) Screening of usage of OCT drugs by means of SERS spectroscopy. In: Plasmonics in biology and medicine XVI. SPIE10.1117/12.2508276 ↗
87. Aymen S et al (2023) Raman spectroscopy for the quantitative analysis of Lornoxicam in solid dosage forms. J Raman Spectrosc 54(3):250–25710.1002/jrs.6476 ↗
88. Miskowski V et al (1975) Copper coordination group in blue copper proteins. Evidence from resonance raman spectra. Biochemistry 14(6):1244–125010.1021/bi00677a024 ↗
89. Ramírez-Contreras D et al (2023) D, l-citrullinato-bipyridine copper complex: experimental and theoretical characterization. Crystals 13(9):139110.3390/cryst13091391 ↗
90. Meng F et al (2017) Ultrasensitive SERS aptasensor for the detection of oxytetracycline based on a gold-enhanced nano-assembly. Talanta 165:412–41810.1016/j.talanta.2016.12.088 ↗
91. Chen S et al (2021) Sensitive aptamer SERS and RRS assays for trace oxytetracycline based on the catalytic amplification of CuNCs. Nanomaterials 11(10):250110.3390/nano11102501 ↗
92. Zhang R et al (2025) Au-Ag alloy nanourchins as a highly efficient SERS tag synergistically with MOF@ Au for the ultrasensitive detection of oxytetracycline. J Colloid Interface Sci. https://doi.org/10.1016/j.jcis.2025.13784010.1016/j.jcis.2025.137840 ↗
93. Koleva BB, Kolev TM, Spiteller M (2008) Determination of cephalosporins in solid binary mixtures by polarized IR-and Raman spectroscopy. J Pharm Biomed Anal 48(1):201–20410.1016/j.jpba.2008.04.026 ↗
94. Shafaq S et al (2022) Quantitative analysis of solid dosage forms of Losartan potassium by Raman spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc 272:12099610.1016/j.saa.2022.120996 ↗
95. Qi J et al (2024) A fluorescence and SERS dual-mode sensing on tetracycline antibiotics based on Ag@ NH2-MIL-101 (Al) nanoprobe. Food Chem 435:13758610.1016/j.foodchem.2023.137586 ↗
96. de Oliveira KV, Rubim JC (2016) Surface-enhanced Raman spectroscopy of molecules adsorbed on silver nanoparticles dispersed an agarose gel and their adsorption isotherms. Vibr Spectrosc 86:290–30110.1016/j.vibspec.2016.08.006 ↗
97. Brawley ZT et al (2021) Angle-independent plasmonic substrates for multi-mode vibrational strong coupling with molecular thin films. J Chem Phys. https://doi.org/10.1063/5.003919510.1063/5.0039195 ↗
98. Xiang Q et al (2025) Highly sensitive and reproducible SERS substrate based on ordered multi-tipped Au nanostar arrays for the detection of myocardial infarction biomarker cardiac troponin I. Analyst 150(11):2239–225010.1039/D5AN00171D ↗
99. Hu Y et al (2025) SERS/fluorescence dual-modal imaging bioprobe for accurate diagnosis of breast cancer. Anal Chem 97(10):5527–553710.1021/acs.analchem.4c05800 ↗
100. Shivaraja TR et al (2025) Remote epilepsy monitoring: signal quality and reliability comparative analysis. IEEE Access. https://doi.org/10.1109/ACCESS.2025.353113010.1109/ACCESS.2025.3531130 ↗