journal article·2025-04-30

Development of a Surface Plasmon Resonance Sensor Based MXene ($${\mathbf{T}\mathbf{i}}3{\mathbf{C}}2{\mathbf{T}}_{\mathbf{x}}$$) for the Detection of Carcinoembryonic Antigen (CEA)

Ali Khodaie, Hamid Bahador, Hamid Heidarzadeh

Plasmonics· Volume 20· Issue 8
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Abstract

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OpenAlex topics: Advanced biosensing and bioanalysis techniques · MXene and MAX Phase Materials · Graphene and Nanomaterials Applications

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References (68)

Show source-provided references
1. Crosby, D., et al., (2022) Early detection of cancer. Science 375(6586): p. eaay9040.10.1126/science.aay9040 ↗
2. Sarhadi VK, Armengol G (2022) Molecular biomarkers in cancer Biomolecules 12(8):1021
3. Abdul NS (2023) Role of advanced diagnostic aids in the detection of potentially malignant disorders and oral cancer at an early stage. Cureus 15(1):e34113
4. Martins, A., et al., (2018) Persistent elevation of carcinoembryonic antigen as first presentation of a medullary thyroid carcinoma. BMJ Case Rep 2018.10.1136/bcr-2017-223233 ↗
5. Hensel JA et al (2019) Recombinant AAV-CEA tumor vaccine in combination with an immune adjuvant breaks tolerance and provides protective immunity. Mol Ther Oncolytics 12:41–4810.1016/j.omto.2018.12.004 ↗
6. Ma R et al (2022) Carbon material hybrid construction on an aptasensor for monitoring surgical tumors. J Anal Methods Chem 2022:974078410.1155/2022/9740784 ↗
7. Hall C et al (2019) A review of the role of carcinoembryonic antigen in clinical practice. Ann Coloproctol 35(6):294–30510.3393/ac.2019.11.13 ↗
8. Li N-L et al (2017) A novel sandwiched electrochemiluminescence immunosensor for the detection of carcinoembryonic antigen based on carbon quantum dots and signal amplification. Biosens Bioelectron 89:453–46010.1016/j.bios.2016.04.020 ↗
9. Pradhan A et al (2021) Biosensors as nano-analytical tools for COVID-19 detection. Sensors 21(23):782310.3390/s21237823 ↗
10. Kokabi M et al (2023) Advancing healthcare: synergizing biosensors and machine learning for early cancer diagnosis. Biosensors 13(9):88410.3390/bios13090884 ↗
11. Șoldănescu I et al (2023) Detection of biological molecules using nanopore sensing techniques. Biomedicines 11(6):162510.3390/biomedicines11061625 ↗
12. Song F-X et al (2023) Recent progress in nanomaterial-based biosensors and theranostic nanomedicine for bladder cancer. Biosensors 13(1):10610.3390/bios13010106 ↗
13. Liu Y, Liu Z, Tian Y (2022) Real-time tracking of electrical signals and an accurate quantification of chemical signals with long-term stability in the live brain. Acc Chem Res 55(19):2821–283210.1021/acs.accounts.2c00333 ↗
14. Bijalwan A, Singh BK, Rastogi V (2021) Analysis of one-dimensional photonic crystal based sensor for detection of blood plasma and cancer cells. Optik 226:16599410.1016/j.ijleo.2020.165994 ↗
15. Gao A et al (2024) Reliable breast cancer miRNAs detection with enhanced silicon nanowire biosensor by PNA probe and optical calibration. Sens Actuators, B Chem 401:13501110.1016/j.snb.2023.135011 ↗
16. Solangi NH et al (2023) Advanced growth of 2D MXene for electrochemical sensors. Environ Res 222:11527910.1016/j.envres.2023.115279 ↗
17. Tyskiewicz R et al (2023) Electrochemical, optical and mass-based immunosensors: a comprehensive review of Bacillus anthracis detection methods. Anal Biochem 675:11521510.1016/j.ab.2023.115215 ↗
18. Nesakumar N, Srinivasan S, Alwarappan S (2022) Graphene quantum dots: synthesis, properties, and applications to the development of optical and electrochemical sensors for chemical sensing. Mikrochim Acta 189(7):25810.1007/s00604-022-05353-y ↗
19. Gao S et al (2024) Ultrasensitive CCL2 detection in urine for diabetic nephropathy diagnosis using a WS(2)-based plasmonic biosensor. Nano Lett 24(17):5301–530710.1021/acs.nanolett.4c00981 ↗
20. Bhattu M, Verma M, Kathuria D (2021) Recent advancements in the detection of organophosphate pesticides: a review. Anal Methods 13(38):4390–442810.1039/D1AY01186C ↗
21. Akimov Y (2018) Optical resonances in Kretschmann and Otto configurations. Opt Lett 43(6):1195–119810.1364/OL.43.001195 ↗
22. Fontana E et al (2015) Microfabricated Otto chip device for surface plasmon resonance-based optical sensing. Appl Opt 54(31):9200–920410.1364/AO.54.009200 ↗
23. Mudgal N et al (2023) ZnO and bi-metallic (Ag–Au) layers based surface plasmon resonance (SPR) biosensor with BaTiO3 and graphene for biosensing applications. IETE J Res 69(2):932–93910.1080/03772063.2020.1844074 ↗
24. Warsi A-Z et al (2022) Synthesis, characterization, photocatalysis, and antibacterial study of WO3, MXene and WO3/MXene nanocomposite. Nanomaterials 12(4):71310.3390/nano12040713 ↗
25. Ghodrati M, Mir A (2022) Improving the performance of a doping-less carbon nanotube FET with dual junction source and drain regions: numerical studies. Journal of Circuits, Systems and Computers 31(10):225018210.1142/S0218126622501821 ↗
26. Shangguan Q et al (2022) Design of ultra-narrow band graphene refractive index sensor. Sensors 22(17):648310.3390/s22176483 ↗
27. Singh, S., et al., (2020)2D nanomaterial-based surface plasmon resonance sensors for biosensing applications. Micromachines (Basel) 11(8).10.3390/mi11080779 ↗
28. Lei ZL, Guo B (2022) 2D Material-based optical biosensor: status and prospect. Adv Sci (Weinh) 9(4):e210292410.1002/advs.202102924 ↗
29. Yadav PK et al (2024) 2D material-based surface plasmon resonance biosensors for applications in different domains: an insight. Mikrochim Acta 191(7):37310.1007/s00604-024-06442-w ↗
30. Kushwaha AS et al (2018) A study of surface plasmon resonance (SPR) based biosensor with improved sensitivity. Photonics Nanostruct Fundam Appl 31:99–10610.1016/j.photonics.2018.06.003 ↗
31. Kumar R et al (2018) Enhancement in sensitivity of graphene-based zinc oxide assisted bimetallic surface plasmon resonance (SPR) biosensor. Appl Phys A 124(3):23510.1007/s00339-018-1606-5 ↗
32. Wu L et al (2018) Few-layer Ti3C2Tx MXene: a promising surface plasmon resonance biosensing material to enhance the sensitivity. Sens Actuators, B Chem 277:210–21510.1016/j.snb.2018.08.154 ↗
33. Srivastava A et al (2020) A theoretical approach to improve the performance of SPR biosensor using MXene and black phosphorus. Optik 203:16343010.1016/j.ijleo.2019.163430 ↗
34. Pandey AK (2021) Graphene–Ti3C2Tx MXene hybrid nanostructure: a promising material for sensitivity enhancement in plasmonic sensor. Appl Phys A 127(2):7810.1007/s00339-020-04235-5 ↗
35. Pal S et al (2019) Sensitivity enhancement using silicon-black phosphorus-TDMC coated surface plasmon resonance biosensor. IET Optoelectron 13(4):196–20110.1049/iet-opt.2018.5023 ↗
36. Singh MK et al (2020) Sensitivity improvement of surface plasmon resonance sensor on using BlueP/MoS2 heterostructure and antimonene. IEEE Sensors Letters 4(7):1–4
37. Kumar A, Kumar A, Srivastava SK (2022) A study on surface plasmon resonance biosensor for the detection of CEA biomarker using 2D materials graphene, Mxene and MoS2. Optik 258:16888510.1016/j.ijleo.2022.168885 ↗
38. Lin Z et al (2022) High-sensitivity PtSe2 surface plasmon resonance biosensor based on metal-Si-metal waveguide structure. Biosensors 12(1):2710.3390/bios12010027 ↗
39. Kotha, V.V., et al., (2024) Ultra-sensitive prism-based surface plasmon resonance biosensor utilizing lead molybdate and BlueP/TDMC nanocomposites for early malaria detection. Plasmonics p. 1–16.10.1007/s11468-024-02726-2 ↗
40. Hma Salah, N., et al., (2025) High-sensitivity optical fiber-based SPR sensor for early cancer cell detection using cerium oxide and tungsten disulfide. Plasmonics p. 1–14.10.1007/s11468-024-02718-2 ↗
41. Vaadaala, J., et al., (2024) Bismuth Tri-borate–Blue phosphorus-based surface plasmon sensor for chlorothalonil pesticide detection. Plasmonics p. 1–13.10.1007/s11468-024-02665-y ↗
42. Vasimalla, Y., B. Kaur, and S. Kumar, (2024)Metallic layer-based SPR biosensor for mycobacterium tuberculosis detection employing zinc oxide and TMDCs heterostructure. IEEE Trans Plasma Sci.10.1109/TPS.2024.3496662 ↗
43. Venkatesan, K.K., S. Samikannu, and S. Singh, (2025) Detection of cancer type cells using surface plasmon resonance employing copper, perovskite, and MXene layer with sensitivity enhancement. Plasmonics p. 1–11.10.1007/s11468-024-02742-2 ↗
44. Ahamed, S., K.K. Venkatesan, and S.A. Jalaludeen, (2025) A review on various surface plasmon resonance-based sensors. Plasmonics p. 1–17.10.1007/s11468-025-02837-4 ↗
45. Butt MA (2025) Surface plasmon resonance-based biodetection systems: principles, progress and applications—a comprehensive review. Biosensors 15(1):3510.3390/bios15010035 ↗
46. Yang, X., et al., (2025) Surface plasmon resonance-based cortisol sensing: a numerical investigation. Plasmonics p. 1–10.10.1007/s11468-025-02895-8 ↗
47. Cho SH et al (2025) Advancements in surface plasmon resonance sensors for real-time detection of chemical analytes: sensing materials and applications. Journal of Materials Chemistry C 13(13):6484–650710.1039/D4TC04890C ↗
48. Sriram, B., et al., (2025) Developing 2D sandwich structures of Ag@ BiFeO3/x-phosphorus (x-Blue, Black)/graphene-assisted SPR biosensors for diverse bacteria cell detection. Plasmonics p. 1–11.10.1007/s11468-025-02855-2 ↗
49. Vankalayapati, S., et al., (2024) Design of a dual-metal layer SPR biosensor for enhanced melamine detection using black phosphorus nanomaterials. Plasmonics p. 1–12.10.1007/s11468-024-02716-4 ↗
50. Kumar S, Yadav A, Malomed BA (2024) Bimetal thin film, semiconductors, and 2D nanomaterials in SPR biosensors: an approach to enhanced urine glucose sensing. IEEE Trans Nanobioscience 23(2):336–34310.1109/TNB.2024.3354571 ↗
51. Houari, F., et al., (2024) Nanosensors based on bimetallic plasmonic layer and black phosphorus: application to urine glucose detection. Sensors (Basel) 24(15).10.3390/s24155058 ↗
52. Almawgani, A.H.M., et al., (2022) Optical detection of fat concentration in milk using MXene-based surface plasmon resonance structure. Biosensors (Basel) 12(7).10.3390/bios12070535 ↗
53. Ahmed R et al (2020) Tunable fano-resonant metasurfaces on a disposable plastic-template for multimodal and multiplex biosensing. Adv Mater 32(19):e190716010.1002/adma.201907160 ↗
54. Wang L et al (2021) Thorium(IV) adsorption onto multilayered Ti(3)C(2)T(x) MXene: a batch, X-ray diffraction and EXAFS combined study. J Synchrotron Radiat 28(Pt 6):1709–171910.1107/S160057752101064X ↗
55. Lertvachirapaiboon C et al (2021) Dual-mode surface plasmon resonance sensor chip using a grating 3D-printed prism. Anal Chim Acta 1147:23–2910.1016/j.aca.2020.12.027 ↗
56. Ghodrati M, Mir A, Farmani A (2023) Numerical analysis of a surface plasmon resonance based biosensor using molybdenum disulfide, molybdenum trioxide, and MXene for the diagnosis of diabetes. Diam Relat Mater 132:10963310.1016/j.diamond.2022.109633 ↗
57. Nguyen, T.T., et al., (2021) Enhanced sensitivity and detection of near-infrared refractive index sensor with plasmonic multilayers. Sensors (Basel) 21(21).10.3390/s21217056 ↗
58. Bahador, H., (2024) Five-segment THz refractive index metamaterial biosensor with perfect absorption for carcinoembryonic antigen measurement. IEEE Sensors J.10.1109/JSEN.2024.3423451 ↗
59. Kumar A, Verma P, Jindal P (2022) Surface plasmon resonance biosensor based on a D-shaped photonic crystal fiber using Ti3C2Tx MXene material. Opt Mater 128:11239710.1016/j.optmat.2022.112397 ↗
60. Mao, Y., et al., (2024) Highly sensitive PCF-SPR RI sensor for cancer detection using gold/graphene/Ti3C2Tx-MXene hybrid layer. Plasmonics10.1007/s11468-024-02467-2 ↗
61. Venkatesan, K.K. and S. Samikannu, (2024) SARS-CoV-2 detection using black phosphorus-MXene-black phosphorus heterostructure surface plasmon resonance biosensor. Plasmonics.10.1007/s11468-024-02545-5 ↗
62. Wekalao, J., et al., (2024) Detection of proteins in a surface plasmon resonance biosensor based on hybrid metasurface architecture and behaviour prediction using random forest regression. Plasmonics.10.1007/s11468-024-02712-8 ↗
63. Hossain B et al (2022) A highly sensitive surface plasmon resonance biosensor using SnSe allotrope and heterostructure of BlueP/MoS2 for cancerous cell detection. Optik 252:16850610.1016/j.ijleo.2021.168506 ↗
64. Karki B et al (2022) Hemoglobin detection in blood samples using a graphene-based surface plasmon resonance biosensor. Optik 270:16994710.1016/j.ijleo.2022.169947 ↗
65. Alam MK et al (2023) Bismuth telluride, graphene, and silver based surface plasmon resonance biosensor for dental application. Opt Quant Electron 55(5):47410.1007/s11082-023-04703-1 ↗
66. Basak C, Hosain MK, Sazzad AA (2020) Design and simulation of a high sensitive surface plasmon resonance biosensor for detection of biomolecules. Sensing and Imaging 21:1–1910.1007/s11220-019-0267-6 ↗
67. Basak, C., et al., (2024) An ultra-sensitive surface plasmon resonance biosensor with PtSe2 and BlueP/WS2 heterostructure. Heliyon 10(19).10.1016/j.heliyon.2024.e38499 ↗
68. Basak C et al (2023) Design and modeling of an angular interrogation based surface plasmon resonance biosensor for dengue virus detection. Opt Quant Electron 55(5):43810.1007/s11082-023-04708-w ↗