Ultra-Sensitive Surface Plasmon Resonance Biosensor for Liver Metastases and Hepatocellular Carcinoma Detection Using Silicon Nitride and Black Phosphorus Nanomaterial
Source abstract
Abstract
In the present study, an ultra-sensitive surface plasmon resonance biosensor is developed. The device is composed of a CaF2-prism, silver, silicon nitride, nickel, and black phosphorus have been deposited. The setup is grounded in the Kretschmann configuration and theoretically analyzed by means of transfer matrix method and Fresnel equations. For selective diagnosis of liver tissue and its mutation in terms of variation in RI, the biosensor provides an ultrahigh angular sensitivity of 383.62°/RIU for MET tissue and 403.92°/RIU for HCC tissue. The optimization of angular sensitivity and other sensor parameters in terms of thickness and number of layers has also been utilized. To validate the reflectance curve, electric field intensity enhancement factor and phase interrogation have also been conducted. The acquired results state that the proposed biosensor yields an enhanced sensitivity when compared to other reported results. Due to its advantage of fast, accurate and early-stage detection of liver mutations with a very small number of samples, this report may expedite a sensing device for commercial applications.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Plasmonic and Surface Plasmon Research · Advanced biosensing and bioanalysis techniques · Gold and Silver Nanoparticles Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (48)
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