Improved biocompatibility of anodized titanium implants by MnO nanoparticles
Source abstract
Abstract
The surface addition of biocompatible metal oxide nanoparticles can significantly affect the physical, chemical, and biological properties of anodized titanium implants. Manganese is an important element for bone growth and regeneration and is essential for the body`s vital systems. In this study, the biological properties of anodized titanium implants decorated with MnO nanoparticles were studied. At first, the effect of anodic oxidation voltage (15 V, 20 V, and 25 V) on the microstructure of titanium oxide nanotubes (TNTs) was investigated. Microstructural studies showed that the diameters of TNTs are increased by raising the applied voltage. Prepared TNTs with the applied voltage of 25 V exhibited a more uniform structure with an average inner diameter of 102 ± 15 nm. In the next step, MnO nanoparticles were synthesized through the thermal decomposition method. The effects of different surfactants, such as oleic acid and oleylamine, and various solvents, including dibenzyl ether and octadecene, on the size and morphology of the synthesized nanoparticles were studied. The results indicated that the MnO nanoparticles synthesized by dibenzyl ether solvent and oleic acid surfactant showed the smallest size and uniform morphology. Finally, the synthesized TNTs were decorated by the optimized MnO nanoparticles using the hydrothermal technique. X-ray diffraction (XRD) analysis was used to phase characterization. Microstructural studies were carried out by field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) analysis. MTT and cell morphology tests were carried out for the biocompatibility evaluation of the specimens. The results showed that the anodized titanium decorated with MnO nanoparticles indicated the highest cell viability compared to the anodized and untreated samples. Microstructural studies demonstrated that the cells attached to the surface and spreading of filopodia in the anodized titanium decorated with MnO nanoparticles are higher than the other samples.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Graphene and Nanomaterials Applications · Laser-Ablation Synthesis of Nanoparticles
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (93)
Show source-provided references
1. Iron(III) and manganese(II) substituted hydroxyapatite nanoparticles: characterization and cytotoxicity analysis10.1088/1742-6596/187/1/012024 ↗
2. Dual modulation of bone formation and resorption with zoledronic acid-loaded biodegradable magnesium alloy implants improves osteoporotic fracture healing: an in vitro and in vivo study10.1016/j.actbio.2017.10.033 ↗
3. Corrosion behavior of a welded stainless-steel orthopedic implant10.1016/S0142-9612(00)00185-X ↗
4. Bacterial and osteoblast behavior on titanium, cobalt–chromium alloy and stainless steel treated with alkali and heat: a comparative study for potential orthopedic applications10.1016/j.jcis.2013.11.062 ↗
5. Niinomi · 2015
6. Recent progress in Mg-based alloys as a novel bioabsorbable biomaterials for orthopedic applications10.1016/j.jma.2022.02.013 ↗
7. TiO2 nanotube arrays induced deposition of hydroxyapatite coating by hydrothermal treatment10.1016/j.matchemphys.2012.12.043 ↗
8. Surface finish machining of medical parts using Plasma electrolytic polishing10.1016/j.procir.2015.07.038 ↗
9. Park · ASM Handbook Volume 23 · 2012 · 23
10. Titanium coatings and surface modifications: toward clinically useful bioactive implants10.1021/acsbiomaterials.6b00604 ↗
11. Corrosion and surface modification on biocompatible metals: a review10.1016/j.msec.2017.04.102 ↗
12. Controlling cell behavior through the design of biomaterial surfaces: a focus on surface modification techniques10.1002/admi.201900572 ↗
13. Surface modification of titanium and titanium alloys: technologies, developments, and future interests10.1002/adem.201901258 ↗
14. Surface modifications of Ti and its alloys
15. Review of titanium surface modification techniques and coatings for antibacterial applications10.1016/j.actbio.2018.10.036 ↗
16. Surface properties and bioactivity of TiO2 nanotube array prepared by two-step anodic oxidation for biomedical applications10.1098/rsos.181948 ↗
17. Nano-hydroxyapatite crystal formation based on calcified TiO2 nanotube arrays10.1016/j.apsusc.2019.01.226 ↗
18. Grimes · 2009
19. Electrochemically assisted photocatalysis on self-organized TiO2 nanotubes10.1016/j.elecom.2007.10.002 ↗
20. Aligned metal oxide nanotube arrays: key-aspects of anodic TiO 2 nanotube formation and properties10.1039/C6NH00054A ↗
21. Local drug delivery to the bone by drug-releasing implants: perspectives of nano-engineered titania nanotube arrays10.4155/tde.12.66 ↗
22. Fabrication of mechanically robust, large area, polycrystalline nanotubular/porous TiO2 membranes10.1016/j.memsci.2008.03.050 ↗
23. An overview of the analytical characterization of nanostructured drug delivery systems: towards green and sustainable pharmaceuticals: a review10.1016/j.aca.2012.07.010 ↗
24. Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes10.1016/j.biomaterials.2007.07.037 ↗
25. Antibacterial coatings on titanium implants10.1002/jbm.b.31463 ↗
26. Antibacterial nano-structured titania coating incorporated with silver nanoparticles10.1016/j.biomaterials.2011.04.040 ↗
27. Bioactive SrTiO3 nanotube arrays: strontium delivery platform on Ti-based osteoporotic bone implants10.1021/nn9007675 ↗
28. Size tuning of Ag‐decorated TiO2 nanotube arrays for improved bactericidal capacity of orthopedic implants10.1002/jbm.a.34934 ↗
29. Ag (Pt) nanoparticles-decorated bioactive yet antibacterial Ca-and P-doped TiO2 coatings produced by plasma electrolytic oxidation and ion implantation10.1016/j.apsusc.2020.146068 ↗
30. Jia B., Yang H., Han Y., Zhang Z., Qu X., Zhuang Y., et al. Acta Biomaterialia In vitro and in vivo studies of Zn-Mn biodegradable metals designed for orthopedic applications, 108, 2020, pp. 358–372.10.1016/j.actbio.2020.03.009 ↗
31. Fabricated antibacterial and bioactive titania nanotube arrays coating on the surface of titanium10.4236/ojsst.2013.33007 ↗
32. Effects of thirty elements on bone metabolism10.1016/j.jtemb.2015.06.005 ↗
33. Dual function of magnesium in bone biomineralization10.1002/adhm.201901030 ↗
34. Bone formation within alumina tubes: effect of calcium, manganese, and chromium dopants10.1016/j.biomaterials.2004.01.005 ↗
35. B. Jia H. Yang Y. Han Z. Zhang X. Qu Y. Zhuang et al. Dai K. Vitr Vivo Stud Zn-Mn Biodegrad Met Des Orthop Appl Acta Biomater 2020;108, pp. 358–372.10.1016/j.actbio.2020.03.009 ↗
36. Manganese oxide and docetaxel co-loaded fluorescent polymer nanoparticles for dual modal imaging and chemotherapy of breast cancer10.1016/j.jconrel.2015.04.020 ↗
37. Hollow polydopamine spheres with removable manganese oxide nanoparticle caps for tumor microenvironment-responsive drug delivery10.1016/j.cej.2021.133089 ↗
38. Theranostic lyotropic liquid crystalline nanostructures for selective breast cancer imaging and therapy10.1016/j.actbio.2020.06.023 ↗
39. Synthesis of titanium oxide nanotubes and their decoration by MnO nanoparticles for biomedical applications10.1016/j.ceramint.2019.06.177 ↗
40. Manganese supplementation improves mineral density of the spine and femur and serum osteocalcin in rats10.1007/s12011-008-8119-6 ↗
41. Enhancing biological properties of porous coatings through the incorporation of manganese10.1016/j.jallcom.2013.07.106 ↗
42. Yu L., Rowe D.W., Perera I.P., Zhang J., Suib S.L., Xin X., et al. Intra fibrillar Mineralized Collagen − Hydroxyapatite-Based Sca ff olds for Bone Regeneration, 2020.10.1021/acsami.0c00275 ↗
43. Effects of manganese incorporation on the morphology, structure and cytotoxicity of spherical bioactive glass nanoparticles10.1016/j.jcis.2019.04.016 ↗
44. Osteogenic potential of sol – gel bioactive glasses containing manganese
45. Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications
46. Applications and biological activity of nanoparticles of manganese and manganese oxides in in vitro and in vivo models10.3390/nano11051084 ↗
47. MnO nanoparticles with potential application in magnetic resonance imaging and drug delivery for myocardial infarction10.2147/IJN.S176404 ↗
48. Nalwa · 1999 · Five-Volume Set
49. Magnetic nanoparticles: synthesis, protection, functionalization, and application10.1002/anie.200602866 ↗
50. Recent advances in multifunctional magnetic nanoparticles and applications to biomedical diagnosis and treatment10.1039/c3ra40348c ↗
51. Hydrothermal preparation of nanostructured manganese oxides (MnOx) and their electrochemical and photocatalytic properties10.1016/j.cej.2011.05.070 ↗
52. Nanorods of manganese oxalate: a single source precursor to different manganese oxide nanoparticles (MnO, Mn 2 O 3, Mn 3 O 4)10.1039/b409010a ↗
53. Sonochemical synthesis, characterization and optical analysis of some metal oxide nanoparticles (MO-NP; M= Ni, Zn and Mn)10.1016/j.physb.2010.06.041 ↗
54. Large‐pore mesoporous‐silica‐coated upconversion nanoparticles as multifunctional immunoadjuvants with ultrahigh photosensitizer and antigen loading efficiency for improved cancer photodynamic immunotherapy10.1002/adma.201802479 ↗
55. Thermal decomposition mechanism of single-molecule precursors forming metal sulfide nanoparticles10.1021/ja905353a ↗
56. Synthesis of uniformly sized manganese oxide nanocrystals with various sizes and shapes and characterization of their T1 magnetic resonance relaxivity10.1002/ejic.201101193 ↗
57. Synthesis and characterization of monodisperse manganese oxide nanoparticles− evaluation of the nucleation and growth mechanism10.1021/cm900663t ↗
58. Synthesis, characterization, and magnetic properties of uniform-sized MnO nanospheres and nanorods10.1021/jp048229e ↗
59. Formation of octapod MnO nanoparticles with enhanced magnetic properties through kinetically-controlled thermal decomposition of polynuclear manganese complexes10.1039/C3NR04832B ↗
60. Size‐dependent magnetic properties of colloidal Mn3O4 and MnO nanoparticles10.1002/anie.200352400 ↗
61. Synthesis of MnO, Mn2O3 and Mn3O4 nanocrystal clusters by thermal decomposition of manganese glycerolate10.1016/j.ceramint.2014.08.108 ↗
62. Gubin · 2009
63. Effect of heat treatment on the properties and structure of TiO2 nanotubes: phase composition and chemical composition
64. A microscopy study of the effect of heat treatment on the structure and properties of anodised TiO2 nanotubes10.1016/j.apsusc.2009.09.078 ↗
65. A review of growth mechanism, structure and crystallinity of anodized TiO2 nanotubes10.1016/j.mser.2013.10.001 ↗
66. TiO2 nanotubes: Self-organized electrochemical formation, properties and applications10.1016/j.cossms.2007.08.004 ↗
67. Improved bone-forming functionality on diameter-controlled TiO 2 nanotube surface10.1016/j.actbio.2009.05.008 ↗
68. TiO2 nanotube platforms for smart drug delivery: a review10.2147/IJN.S108847 ↗
69. Hydroxyapatite growth on anodic TiO2 nanotubes10.1002/jbm.a.30677 ↗
70. Synthesis and characterization of monodisperse manganese oxide nanoparticles-evaluation of the nucleation and growth mechanism
71. Platinum attachments on iron oxide nanoparticle surfaces10.1063/1.3355899 ↗
72. Systematic control of size, shape, structure, and magnetic properties of uniform magnetite and maghemite particles10.1016/S0021-9797(03)00511-3 ↗
73. Size-dependent properties of magnetic iron oxide nanocrystals10.1039/C0NR00521E ↗
74. Influence of iron oleate complex structure on iron oxide nanoparticle formation10.1021/cm062948j ↗
75. Ultra-large-scale syntheses of monodisperse nanocrystals10.1038/nmat1251 ↗
76. Experimental methods in chemical engineering: specific surface area and pore size distribution measurements—BET, BJH, and DFT10.1002/cjce.23632 ↗
77. Physisorption of gases, with special reference to the evaluation of surface area and pore size distribution (IUPAC Technical Report)10.1515/pac-2014-1117 ↗
78. Agglomeration and sedimentation of TiO2 nanoparticles in cell culture medium10.1016/j.colsurfb.2008.09.014 ↗
79. In vitro bioactivity and corrosion resistance of Zr incorporated TiO2 nanotube arrays for orthopaedic applications10.1016/j.apsusc.2014.08.001 ↗
80. Resistance of solid surfaces to wetting by water10.1021/ie50320a024 ↗
81. The summary of the most important cell-biomaterial interactions that need to be considered during in vitro biocompatibility testing of bone scaffolds for tissue engineering applications10.1016/j.msec.2019.01.061 ↗
82. ISO ISO. 10993–5 · 2009
83. Surface modification of stainless steel orthopedic implants by sol–gel ZrTiO4 and ZrTiO4–PMMA coatings10.1166/jbn.2013.1619 ↗
84. The biocompatibility of HA thin films deposition on anodized titanium alloys10.1016/j.surfcoat.2010.08.015 ↗
85. The biocompatibility of HA thin films deposition on anodized titanium alloys10.1016/j.surfcoat.2010.08.015 ↗
86. Oxidized implants and their influence on the bone response10.1023/A:1012837905910 ↗
87. P25 nanoparticles decorated on titania nanotubes arrays as effective drug delivery system for ibuprofen10.1016/j.apsusc.2014.10.147 ↗
88. In vitro study of manganese-doped bioactive glasses for bone regeneration10.1016/j.msec.2014.01.045 ↗
89. Controlled oxidative nanopatterning of microrough titanium surfaces for improving osteogenic activity10.1007/s10856-014-5232-2 ↗
90. Significantly accelerated osteoblast cell growth on aligned TiO2 nanotubes10.1002/jbm.a.30722 ↗
91. Enhanced osteointegration of medical titanium implant with surface modifications in micro/nanoscale structures
92. Effect of nanotube diameters on bioactivity of a multifunctional titanium alloy10.1016/j.apsusc.2012.11.142 ↗
93. In vitro study of manganese-doped bioactive glasses for bone regeneration10.1016/j.msec.2014.01.045 ↗