Customized impedance spectroscopy device as possible sensor platform for biosensor applications

Abstract A new impedance spectroscopy unit is developed, fully customized to become a vital part of label free biosensor arrays with possible applications in DNA and protein sensing. Test measurements are conducted to explore the accuracy and specificity of the system, both under electronic lab conditions as well as under wet cell conditions with synthetic‐diamond based sensor electrodes. The impedance of seven resistors was monitored for 17 h and a maximum error <0.02% was found. Furthermore, the impedance of PBS at different concentrations was monitored for 60 min per concentration and a different impedance for each concentration was detected. The impedance is also monitored for NaOH, PBS and nuclease free water at different temperatures with a total duration of 60 min per fluid. Systematically different impedances for each temperature per fluid were found and the temperature coefficients were determined. All test measurements lead to results well within specification.