Impact of the spindle number on the material transport and mixing during planetary roller melt granulation
Source abstract
Abstract
In comparison to the established twin-screw machines, the application of a planetary roller granulator for continuous operation of melt granulation is a promising alternative based on the unique process concept. An initial study focused on the material transport during processing as a key driver for the overall performance. Hereby, the impact of direct process parameters on the residence time distribution was the main objective. These investigations are complemented in this study by considering the free processing volume, which is defined by the number of planetary spindles applied within a module. The impact on the processing conditions is evaluated with respect to the process setting in terms of feed rate and rotation speed. The results highlight the potential of altering the underlying transport function in planetary roller melt granulation (PRMG) via the investigated direct process and equipment parameters. The impact of the feed rate is lower in comparison, while a higher rotation speed as well as a higher free processing volume promote material mixing. Moreover, a normalization of the determined residence time distribution (RTD) model data was feasible with respect to the process settings and the number of applied planetary spindles in the processing zone. This demonstrates the key role of the free processing volume in the fundamental mechanisms of material transport and mixing during PRMG.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Granular flow and fluidized beds · Mineral Processing and Grinding · Additive Manufacturing and 3D Printing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (38)
Show source-provided references
1. Impact of melt processing conditions on the degradation of Polylactic Acid10.3390/polym14142790 ↗
2. Using residence time distribution in pharmaceutical solid dose manufacturing-A critical review10.1016/j.ijpharm.2021.121248 ↗
3. Investigating local residence time and thermomechanical stress profile in twin-screw extrusion of plant proteins by using the moving particle semi-implicit simulation method10.1016/j.jfoodeng.2023.111665 ↗
4. Experimental and numerical investigations of the RTD in a GEA ConsiGma CTL25 tablet press10.1016/j.powtec.2022.117507 ↗
5. Twin-screw melt granulation for oral solid pharmaceutical products10.3390/pharmaceutics13050665 ↗
6. Integrated continuous wet granulation and Drying: Process evaluation and comparison with Batch processing10.3390/pharmaceutics15092317 ↗
7. Influence of process temperature and residence time on the manufacturing of amorphous solid dispersions in hot melt extrusion10.1080/10837450.2022.2051549 ↗
8. Process design of continuous powder blending using residence time distribution and feeding models10.3390/pharmaceutics12111119 ↗
9. 2023
10. Nucleation, growth and breakage phenomena in agitated wet granulation processes: A review10.1016/S0032-5910(01)00313-8 ↗
11. Measurement of residence time distributions and material tracking on three continuous manufacturing lines10.1016/j.ijpharm.2019.03.058 ↗
12. Kleinebudde · 2017
13. Kohlgrüber · 2016
14. Material transport characteristics in planetary roller melt granulation10.3390/pharmaceutics15082039 ↗
15. Modelling drug degradation of amorphous solid dispersion during twin-screw extrusion10.1016/j.ejpb.2023.07.020 ↗
16. Planetary roller melt granulation (PRMG)-A new continuous method for powder processing10.1016/j.powtec.2023.118728 ↗
17. From powder to tablets: Investigation of residence time distributions in a continuous manufacturing process train as basis for continuous process verification10.1016/j.ejpb.2020.05.030 ↗
18. Challenges in tracing material flow passing a loss-in-weight feeder in continuous manufacturing processes10.1016/j.ijpharm.2021.121304 ↗
19. Parametric study of residence time distributions and granulation Kinetics as a basis for process modeling of twin-screw wet granulation10.3390/pharmaceutics13050645 ↗
20. Using twin-screw melt granulation to co-process mannitol and hydroxypropylcellulose10.1016/j.jddst.2022.103880 ↗
21. Impact of particle and equipment properties on residence time distribution of pharmaceutical Excipients in rotary tablet Presses10.3390/pharmaceutics12030283 ↗
22. Selection of an appropriate tracer to measure the residence time distribution (RTD) of continuous powder blending operations10.1016/j.powtec.2023.118864 ↗
23. Residence time modeling of hot melt extrusion processes10.1016/j.ejpb.2013.07.019 ↗
24. Implementation of a fully integrated CM direct compression and coating process at a commercial pharmaceutical facility-Part 2: PAT and RTD results for normal operational conditions batches10.1016/j.ijpharm.2023.122814 ↗
25. Comparative analysis of granule properties in continuous granulators10.1016/j.powtec.2023.118557 ↗
26. Serno · 2007
27. An analysis of the mini-tablet fluidized bed coating process10.1016/j.cherd.2018.03.020 ↗
28. Characterization and propagation of RTD uncertainty for continuous powder blending processes10.1016/j.ijpharm.2022.122326 ↗
29. Characteristics of residence time distribution in a continuous high shear mixer granulation using scraper rotation10.1016/j.ijpharm.2021.120789 ↗
30. Elucidation of granulation mechanisms along the length of the barrel in continuous twin-screw melt granulation10.1016/j.ijpharm.2023.122986 ↗
31. Visualization of the granule temperature using thermal imaging to improve understanding of the granulation mechanism in continuous twin-screw melt granulation10.1016/j.ijpharm.2023.123423 ↗
32. Elucidation and visualization of solid-state transformation and mixing in a pharmaceutical mini hot melt extrusion process using in-line Raman spectroscopy10.1016/j.ijpharm.2016.11.065 ↗
33. Hot-melt granulation in a twin screw extruder: Effects of processing on Formulations with Caffeine and Ibuprofen10.1002/jps.23739 ↗
34. Scale-Up of pharmaceutical Hot-Melt-Extrusion: Process optimization and transfer10.1016/j.ejpb.2019.07.009 ↗
35. Comparison of residence time models for pharmaceutical twin-screw-extrusion processes10.1016/j.powtec.2018.02.054 ↗
36. Optimization of residence time distribution in RCDG and an assessment of its applicability in continuous manufacturing10.1016/j.partic.2020.09.009 ↗
37. In-line monitoring of solid dispersion preparation in small scale extrusion based on UV-vis spectroscopy10.1080/10837450.2022.2144887 ↗
38. Simulations mapping the influence of oxygen, extruder residence time, and mechanical shear on low-density polyethylene structure during recycling10.1016/j.polymer.2022.125596 ↗