Spontaneous ethanol–water emulsification as a precursor for porous particle formation: Understanding the role of dissolved carbohydrates
Source abstract
Abstract
Abstract Quiescent mixing of aqueous lactose solution with ethanol by gentle pouring allowed controlled observation of a transient, spontaneous emulsification process between ethanol and water. This phenomenon contrasts with the conventional stable phase-separation process for ethanol–water systems with other solutes. The presence of lactose in the dissolved state was deduced to be the key factor causing spontaneous emulsification. This explains the transitional behavior of the phenomenon. Further experiments with aqueous maltodextrin solution, using the same experimental technique, confirmed this phenomenon. The mechanisms determined in this work will form the basis of porous-particle synthesis via the antisolvent vapor-precipitation technique.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Innovative Microfluidic and Catalytic Techniques Innovation · Microencapsulation and Drying Processes · Microfluidic and Capillary Electrophoresis Applications
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References (15)
Show source-provided references
1. Properties of sugar, polyol and polysaccharide water-ethanol solutions10.1021/je700190m ↗
2. Lactose microparticle formation from finely atomized droplets10.1016/j.ces.2014.10.001 ↗
3. Reaction Engineering Approach (REA) to model the drying kinetics of droplets with different initial sizes —Experiments and analyses10.1016/j.ces.2011.01.009 ↗
4. Some physico-chemical properties of lactose: II. Factors influencing the crystalline habit of lactose10.3168/jds.S0022-0302(34)93270-7 ↗
5. Ibuprofen agglomerates preparation by phase separation10.1081/DDC-100102174 ↗
6. Preparation of high internal water-phase double emulsions stabilized by a single anionic surfactant for fabricating interconnecting porous polymer microspheres10.1021/la502564r ↗
7. Solid-liquid equilibrium of α-lactose in ethanol/water10.1016/S0378-3812(00)00388-5 ↗
8. Uniform amorphous lactose microspheres formed in simultaneous convective and dehydration antisolvent precipitation under atmospheric conditions10.1021/la302301h ↗
9. Solubility of ibuprofen in some ethanol + water cosolvent mixtures at several temperatures
10. NMR and FT-IR studies of hydrogen bonds in ethanol-water mixtures10.1021/j100010a037 ↗
11. Rashid · 2011
12. Unexpected and successful one-step formation of porous polymeric particles only by mixing organic solvent and water under Low-Energy-Input conditions10.1021/la500324j ↗
13. NaCl-induced phase separation of 1, 4-dioxane-water mixtures studied by large-angle X-ray scattering and small-angle neutron scattering techniques10.1021/jp011692w ↗
14. Preparation of novel silicone multicomponent particles by multiple emulsion templating and their use as encapsulating systems10.1021/la403134c ↗
15. Antisolvent vapour precipitation: The future of pulmonary drug delivery particle production?10.1517/17425247.2014.875527 ↗