Tumor Microenvironment Responsive ACPP‐Conjugated Micelles for Targeted Treatment of Brain Glioma

A multitargeting drug delivery system based on micelles modified with urokinase-type plasminogen activator-sensitive activated cell-penetrating peptides (uPA-ACPP) for the treatment of brain glioma is first developed. Compared with the conventional polyethylene glycol-poly(lactic acid) nanoparticles, smaller size, higher drug loading of micelles are more suitable for brain tumor treatment under the action of uPA-sensitive ACPP. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.