DataVXJournal of Adhesion Science and TechnologyPaper
journal article·2015-10-18

Surface topography effect on fibroblasts population on epiclon-based polyimide films

Iuliana Stoica, Andreea Irina Barzic, Maria Butnaru, Florica Doroftei, Camelia Hulubei

Journal of Adhesion Science and Technology· Volume 29· Issue 20
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Source abstract

Abstract

A polyimide based on alicyclic units, such as epiclon (5-(2,5-dioxotetrahydrofurfuryl)-3-methyl-3-cyclohexene-1,2-dicarboxylic acid anhydride), was investigated from the point of view of its surface features to check their suitability for cell culture applications. Atomic force microscopy data revealed fractal and isotropic surfaces with nanoscale roughness and peaks placed at much smaller distances comparing to the cell size scale, favoring a good compatibility of the synthesized material with the biological medium, particularly after plasma treatment. Surface tension properties were determined in order to evaluate the interactions at the bio-interface affecting the adherence behavior of cell-binding proteins to the sample surface. In vitro experiments regarding the cytocompatibility and population tendency reveal that polyimide allows cells to adhere and to proliferate onto the surface. These tests indicate that the studied epiclon-based polyimide is not cytotoxic and can be recommended as good candidate for cell culture substrate in tissue engineering, especially after plasma treatment.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Synthesis and properties of polymers · Tribology and Wear Analysis · Nanofabrication and Lithography Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Polymer Materials Physics, ‘Petru Poni’ Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley 41A, 700487 Iasi, Romania

Department of Bioresources and Polymer Science, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, str. Gheorghe Polizu, nr 1-7, Sector 1, 011061 Bucharest, Romania

Department of Physical Chemistry of Polymers, ‘Petru Poni’ Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley 41A, 700487 Iasi, Romania

Department of Biomedical Sciences, Faculty of Medical Bioengineering, ‘Grigore T. Popa’ University of Medicine and Pharmacy, University Street 16, 700115 Iasi, Romania

Department of Polycondensation and Thermostable Polymers, ‘Petru Poni’ Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley 41A, 700487 Iasi, Romania

Funding

Sectoral Operational Programme Human Resources Development 2007–2013 of the Ministry of European Funds through the Financial Agreement

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