journal article·2024-09-17Open access

Dynamic assessment of titanium surface oxides following mechanical damage reveals only partial passivation under inflammatory conditions

Georgios A. Kotsakis, Li Xie, Danyal A. Siddiqui, Diane Daubert, Daniel J. Graham, Francisco Javier Gil

npj Materials Degradation· Volume 8· Issue 1

Abstract

Motivated by clinical problems of titanium implant degradation, we developed a workflow that enabled assessment of surface oxide dynamics as a function of clinical interventions and inflammation conditions. We found that mechanical damage led to decrease of stoichiometric TiO 2 ratio in the passivation oxide film and further resulted in accelerated degradation under inflammatory anaerobic conditions. This method can be employed for the assessment of surface oxides to monitor implant safety.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Bone Tissue Engineering Materials · Titanium Alloys Microstructure and Properties · Orthopaedic implants and arthroplasty

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (26)

Show source-provided references
1. Jung, H. D. Titanium and its alloys for biomedical applications. Met. Basel 11, 1945 (2021).
2. Sittig, C., Textor, M., Spencer, N. D., Wieland, M. & Vallotton, P. H. Surface characterization of implant materials cp Ti, Ti-6Al-7Nb and Ti-6Al-4V with different pretreatments. J. Mater. Sci. Mater. M 10, 35–46 (1999).10.1023/A:1008840026907 ↗
3. Wheelis, S. E., Wilson, T. G., Valderrama, P. & Rodrigues, D. C. Surface characterization of titanium implant healing abutments before and after placement. Clin. Implant Dent. R. 20, 180–190 (2018).10.1111/cid.12566 ↗
4. Apaza-Bedoya, K. et al. Synergistic interactions between corrosion and wear at titanium-based dental implant connections: a scoping review. J. Periodontal Res 52, 946–954 (2017).10.1111/jre.12469 ↗
5. Wu, H. et al. A wear-resistant TiO nanoceramic coating on titanium implants for visible-light photocatalytic removal of organic residues. Acta Biomater. 97, 597–607 (2019).10.1016/j.actbio.2019.08.009 ↗
6. Chen, L. et al. Titanium particles in peri-implantitis: distribution, pathogenesis and prospects. Int J. Oral. Sci. 15, 49 (2023).10.1038/s41368-023-00256-x ↗
7. Yang, T. et al. Residual extracellular polymeric substances (EPS) detected by fluorescence microscopy on dental implants after different decontamination. Mater. Chem. Phys. 296, 127242 (2023).10.1016/j.matchemphys.2022.127242 ↗
8. Veerachamy, S., Yarlagadda, T., Manivasagam, G. & Yarlagadda, P. K. D. V. Bacterial adherence and biofilm formation on medical implants: a review. P I Mech. Eng. H. 228, 1083–1099 (2014).10.1177/0954411914556137 ↗
9. Hirota, M. et al. Impaired osteoblastic behavior and function on saliva-contaminated titanium and its restoration by UV treatment. Mat. Sci. Eng. C. Mater. 100, 165–177 (2019).10.1016/j.msec.2019.03.008 ↗
10. Yang, X. J., Du, C. W., Wan, H. X., Liu, Z. Y. & Li, X. G. Influence of sulfides on the passivation behavior of titanium alloy TA2 in simulated seawater environments. Appl Surf. Sci. 458, 198–209 (2018).10.1016/j.apsusc.2018.07.068 ↗
11. Kotsakis, G. A. et al. Effect of implant cleaning on titanium particle dissolution and cytocompatibility. J. Periodontol. 92, 580–591 (2021).10.1002/JPER.20-0186 ↗
12. Eger, M. et al. Mechanism and prevention of titanium particle-induced inflammation and osteolysis. Front Immunol. 9, 2963 (2018).10.3389/fimmu.2018.02963 ↗
13. Wang, L. et al. Local fine structural insight into mechanism of electrochemical passivation of titanium. Acs Appl Mater. Inter 8, 18608–18619 (2016).10.1021/acsami.6b05080 ↗
14. Sridhar, S. et al. Multifaceted roles of environmental factors toward dental implant performance: Observations from clinical retrievals and testing. Dent. Mater. 34, E265–E279 (2018).10.1016/j.dental.2018.08.299 ↗
15. Jenko, M. et al. Surface chemistry and microstructure of metallic biomaterials for hip and knee endoprostheses. Appl Surf. Sci. 427, 584–593 (2018).10.1016/j.apsusc.2017.08.007 ↗
16. Lamont, E. I. et al. Modified SHI medium supports growth of a disease-state subgingival polymicrobial community in vitro. Mol. Oral. Microbiol 36, 37–49 (2021).10.1111/omi.12323 ↗
17. Monje, A. et al. Strategies for implant surface decontamination in peri-implantitis therapy. Int J. Oral. Impl. 15, 213–249 (2022).
18. Berbel, L. O., Banczek, E. D. P., Karoussis, I. K., Kotsakis, G. A. & Costa, I. Determinants of corrosion resistance of Ti-6Al-4V alloy dental implants in an In Vitro model of peri-implant inflammation. PLoS One 14, e0210530 (2019).10.1371/journal.pone.0210530 ↗
19. Cao, H. L. & Liu, X. Y. Activating titanium oxide coatings for orthopedic implants. Surf. Coat. Tech. 233, 57–64 (2013).10.1016/j.surfcoat.2013.01.043 ↗
20. Sridhar, S. et al. Multifaceted roles of environmental factors toward dental implant performance: observations from clinical retrievals and in vitro testing. Dent. Mater. 34, e265–e279 (2018).10.1016/j.dental.2018.08.299 ↗
21. Koike, M. & Fujii, H. The corrosion resistance of pure titanium in organic acids. Biomaterials 22, 2931–2936 (2001).10.1016/S0142-9612(01)00040-0 ↗
22. Podshivalova, A. K. & Karpov, I. K. Thermodynamic analysis of the stability of titanium oxides in the TiO-TiO range. Russ. J. Inorg. Chem. 52, 1147–1150 (2007).10.1134/S0036023607070273 ↗
23. Greczynski, G. & Hultman, L. Towards reliable X-ray photoelectron spectroscopy: Sputter-damage effects in transition metal borides, carbides, nitrides, and oxides. Appl Surf. Sci. 542, 148599 (2021).10.1016/j.apsusc.2020.148599 ↗
24. Vasconcelos, D. M., Santos, S. G., Lamghari, M. & Barbosa, M. A. The two faces of metal ions: from implants rejection to tissue repair/regeneration. Biomaterials 84, 262–275 (2016).10.1016/j.biomaterials.2016.01.046 ↗
25. Biesinger, M. C., Lau, L. W. M., Gerson, A. R. & Smart, R. S. C. Resolving surface chemical states in XPS analysis of first row transition metals, oxides and hydroxides: Sc, Ti, V, Cu and Zn. Appl Surf. Sci. 257, 887–898 (2010).10.1016/j.apsusc.2010.07.086 ↗
26. Safioti, L. M., Kotsakis, G. A., Pozhitkov, A. E., Chung, W. O. & Daubert, D. M. Increased levels of dissolved titanium are associated with peri-implantitis—a cross-sectional study. J. Periodontol. 88, 436–442 (2017).10.1902/jop.2016.160524 ↗