Smart wearable and implantable biosensors for continuous health monitoring: materials, biocompatibility, and AI integration
Source abstract
Abstract
Abstract Smart wearable and implantable biosensors enable continuous, real-time monitoring of biophysical and biochemical signals for personalized and preventive healthcare. Advances in flexible, stretchable, and biocompatible materials ensure long-term comfort and seamless body integration, while multimodal and multi-analyte sensing improves robustness. AI enhances signal processing and predictive insights, yet challenges remain in motion artifacts, energy autonomy, data privacy, and clinical interpretability. This review summarizes materials, device architectures, and AI-assisted strategies applications.
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Research context
OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Polymer Nanocomposite Synthesis and Irradiation · Prosthetics and Rehabilitation Robotics
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References (100+)
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1. Shankar, S. et al. Nanodot zirconium trisulfide modified conducting thread: a smart substrate for fabrication of next generation biosensor. Biosens. Bioelectron. 242, 115722 (2023).10.1016/j.bios.2023.115722 ↗
2. Heikenfeld, J. et al. Wearable sensors: modalities, challenges, and prospects. Lab Chip 18, 217–248 (2018).10.1039/C7LC00914C ↗
3. Soleymani, L. & Li, F. Mechanistic challenges and advantages of biosensor miniaturization into the nanoscale. ACS Sens. 2, 458–467 (2017).10.1021/acssensors.7b00069 ↗
4. Vo, T. S. et al. Recent trends of bioanalytical sensors with smart health monitoring systems: from materials to applications. Adv. Healthc. Mater. 13, e2303923 (2024).10.1002/adhm.202303923 ↗
5. Wang, L., Lou, Z., Jiang, K. & Shen, G. Bio-multifunctional smart wearable sensors for medical devices. Adv. Intell. Syst. 1, 1900040 (2019).10.1002/aisy.201900040 ↗
6. Ha, M., Lim, S. & Ko, H. Wearable and flexible sensors for user-interactive health-monitoring devices. J. Mater. Chem. B 6, 4043–4064 (2018).10.1039/C8TB01063C ↗
7. Song, Y., Mukasa, D., Zhang, H. & Gao, W. Self-powered wearable biosensors. Acc. Mater. Res. 2, 184–197 (2021).10.1021/accountsmr.1c00002 ↗
8. Hassan, M. et al. Significance of flexible substrates for wearable and implantable devices: recent advances and perspectives. Adv. Mater. Technol. 7, 2100773 (2021).10.1002/admt.202100773 ↗
9. Shan, G., Li, X. & Huang, W. AI-enabled wearable and flexible electronics for assessing full personal exposures. Innovation 1, 100031 (2020).
10. Gideon, O., Samuel, H. S. & Okino, I. A. Biocompatible materials for next-generation biosensors. Discov. Chem. 1, 34 (2024).10.1007/s44371-024-00042-6 ↗
11. Lu, T. et al. Biocompatible and long-term monitoring strategies of wearable, ingestible and implantable biosensors: reform the next generation healthcare. Sensors 23, 2991 (2023).10.3390/s23062991 ↗
12. Zhang, H. et al. Graphene-enabled wearable sensors for healthcare monitoring. Biosens. Bioelectron. 197, 113777 (2022).10.1016/j.bios.2021.113777 ↗
13. Zhu, P., Peng, H. & Rwei, A. Y. Flexible, wearable biosensors for digital health. Med. Nov. Technol. Devices 14, 100118 (2022).10.1016/j.medntd.2022.100118 ↗
14. Yin, Z., Clark, K. M. & Ray, T. R. Emerging additive manufacturing methods for wearable sensors: opportunities to expand access to personalized health monitoring. Adv. Sens. Res. 3, 2300137 (2023).10.1002/adsr.202300137 ↗
15. Wang, Y. et al. Skin bioelectronics towards long-term, continuous health monitoring. Chem. Soc. Rev. 51, 3759–3793 (2022).10.1039/D2CS00207H ↗
16. Vo, D. K. & Trinh, K. T. L. Advances in wearable biosensors for healthcare: current trends, applications, and future perspectives. Biosensors 14, 560 (2024).10.3390/bios14110560 ↗
17. Ren, M. et al. Highly strain-sensitive and stretchable multilayer conductive composite based on aligned thermoplastic polyurethane fibrous mat for human motion monitoring. Compos. Commun. 46, 101840 (2024).10.1016/j.coco.2024.101840 ↗
18. Chen, S. et al. Transforming healthcare: intelligent wearable sensors empowered by smart materials and artificial intelligence. Adv. Mater. 37, e2500412 (2025).10.1002/adma.202500412 ↗
19. Shajari, S., Kuruvinashetti, K., Komeili, A. & Sundararaj, U. The emergence of AI-based wearable sensors for digital health technology: a review. Sensors 23, 9498 (2023).10.3390/s23239498 ↗
20. Gao, W., Ota, H., Kiriya, D., Takei, K. & Javey, A. Flexible electronics toward wearable sensing. Acc. Chem. Res. 52, 523–533 (2019).10.1021/acs.accounts.8b00500 ↗
21. Wei, Y. et al. A biosensor material with robust mechanical properties, fatigue-resistance, biocompatibility, biodegradability, and anti-freezing capabilities. J. Mater. Chem. A 10, 8491–8500 (2022).10.1039/D1TA10998G ↗
22. Chitrakar, C., Hedrick, E., Adegoke, L. & Ecker, M. Flexible and stretchable bioelectronics. Materials 15, 1664 (2022).10.3390/ma15051664 ↗
23. Wang, S., Chinnasamy, T., Lifson, M. A., Inci, F. & Demirci, U. Flexible substrate-based devices for point-of-care diagnostics. Trends Biotechnol. 34, 909–921 (2016).10.1016/j.tibtech.2016.05.009 ↗
24. Kenry, Yeo, J. C. & Lim, C. T. Emerging flexible and wearable physical sensing platforms for healthcare and biomedical applications. Microsyst. Nanoeng. 2, 16043 (2016).10.1038/micronano.2016.43 ↗
25. Bocchetta, P. et al. Soft materials for wearable/flexible electrochemical energy conversion, storage, and biosensor devices. Materials 13, 2733 (2020).10.3390/ma13122733 ↗
26. Yang, Y. et al. Ultrafine graphene nanomesh with large on/off ratio for high-performance flexible biosensors. Adv. Funct. Mater. 27, 1604096 (2016).10.1002/adfm.201604096 ↗
27. Shetti, N. P. et al. Skin-patchable electrodes for biosensor applications: a review. ACS Biomater. Sci. Eng. 6, 1823–1835 (2020).10.1021/acsbiomaterials.9b01659 ↗
28. Saeidi, M. et al. Electrochemical wearable biosensors and bioelectronic devices based on hydrogels: mechanical properties and electrochemical behavior. Biosensors 13, 823 (2023).10.3390/bios13080823 ↗
29. Kim, S. et al. An intrinsically stretchable multi-biochemical sensor for sweat analysis using photo-patternable ecoflex. npj Flex Electron. 7, 33 (2023).10.1038/s41528-023-00268-x ↗
30. Maiya, D., Patel, T. & Pandya, A. In Progress in Molecular Biology and Translational Science (eds K. Mahato & A. Pandya) Ch. 5 (Academic Press, 2025).
31. Oh, B. et al. Ultra-soft and highly stretchable tissue-adhesive hydrogel based multifunctional implantable sensor for monitoring of overactive bladder. Biosens. Bioelectron. 225, 115060 (2023).10.1016/j.bios.2023.115060 ↗
32. Lee, S. H. et al. Intrinsically soft implantable electronics for long-term biosensing applications. Adv. Sens. Res. 4, 2500002 (2025).10.1002/adsr.202500002 ↗
33. Souri, H. et al. Wearable and stretchable strain sensors: materials, sensing mechanisms, and applications. Adv. Intell. Syst. 2, 2000039 (2020).10.1002/aisy.202000039 ↗
34. Salim, A. & Lim, S. Recent advances in noninvasive flexible and wearable wireless biosensors. Biosens. Bioelectron. 141, 111422 (2019).10.1016/j.bios.2019.111422 ↗
35. Vedadghavami, A. et al. Manufacturing of hydrogel biomaterials with controlled mechanical properties for tissue engineering applications. Acta Biomater. 62, 42–63 (2017).10.1016/j.actbio.2017.07.028 ↗
36. Liu, Q. et al. Bio-based elastomers: design, properties, and biomedical applications.Adv. Mater. 37, e2417193 (2025).10.1002/adma.202417193 ↗
37. Prasadh, S. & Wong, R. C. W. Unraveling the mechanical strength of biomaterials used as a bone scaffold in oral and maxillofacial defects. Oral Sci. Int. 15, 48–55 (2018).10.1016/S1348-8643(18)30005-3 ↗
38. Niinomi, M. & Nakai, M. Titanium-based biomaterials for preventing stress shielding between implant devices and bone. Int. J. Biomater. 2011, 836587 (2011).10.1155/2011/836587 ↗
39. Ge, Z., Yang, F., Goh, J. C., Ramakrishna, S. & Lee, E. H. Biomaterials and scaffolds for ligament tissue engineering. J. Biomed. Mater. Res. A 77, 639–652 (2006).10.1002/jbm.a.30578 ↗
40. Tan, E. L. et al. Implantable biosensors for real-time strain and pressure monitoring. Sensors 8, 6396–6406 (2008).10.3390/s8106396 ↗
41. Wang, L. & Beebe, D. J. Characterization of a silicon-based shear-force sensor on human subjects. IEEE Trans. Biomed. Eng. 49, 1340–1347 (2002).10.1109/TBME.2002.804586 ↗
42. Wu, S. J. & Zhao, X. Bioadhesive technology platforms. Chem. Rev. 123, 14084–14118 (2023).10.1021/acs.chemrev.3c00380 ↗
43. Wong, S. H. D. et al. Smart skin-adhesive patches: from design to biomedical applications. Adv. Funct. Mater. 33, 2213560 (2023).10.1002/adfm.202213560 ↗
44. Liu, X. et al. Bioinspired, microstructured silk fibroin adhesives for flexible skin sensors. ACS Appl. Mater. Interfaces 12, 5601–5609 (2020).10.1021/acsami.9b21197 ↗
45. Liu, H. et al. Application of biodegradable and biocompatible nanocomposites in electronics: current status and future directions. Nanomaterials 9, 950 (2019).10.3390/nano9070950 ↗
46. Xu, M., Obodo, D. & Yadavalli, V. K. The design, fabrication, and applications of flexible biosensing devices. Biosens. Bioelectron. 124-125, 96–114 (2019).10.1016/j.bios.2018.10.019 ↗
47. Kim, J. et al. Ultrathin soft wearable sensor materials and structures: a review of current trends and prospectives. ACS Appl. Mater. Interfaces 17, 59994–60027 (2025).10.1021/acsami.5c14329 ↗
48. Lee, S. et al. An ultrathin conformable vibration-responsive electronic skin for quantitative vocal recognition. Nat. Commun. 10, 2468 (2019).10.1038/s41467-019-10465-w ↗
49. Kwon, S. et al. Skin-conformal, soft material-enabled bioelectronic system with minimized motion artifacts for reliable health and performance monitoring of athletes. Biosens. Bioelectron. 151, 111981 (2020).10.1016/j.bios.2019.111981 ↗
50. Reis Carneiro, M., Tavakoli, M. & Majidi, C. Soft skin-interfacing electrodes for wearable bioelectronics. Matter 8, 102409 (2025).10.1016/j.matt.2025.102409 ↗
51. Wang, R. et al. Wet chemically produced nanomaterials for soft wearable biosensors. Nanoscale Horiz. 10, 1517–1541 (2025).10.1039/D5NH00048C ↗
52. Gao, W. et al. Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature 529, 509–514 (2016).10.1038/nature16521 ↗
53. Ershad, F. et al. Ultra-conformal drawn-on-skin electronics for multifunctional motion artifact-free sensing and point-of-care treatment. Nat. Commun. 11, 3823 (2020).10.1038/s41467-020-17619-1 ↗
54. Jung, H. et al. Hydrogel-elastomer-based conductive nanomembranes for soft bioelectronics. Nat. Nanotechnol. 20, 1822–1830 (2025).10.1038/s41565-025-02031-x ↗
55. Park, J. et al. Conformal fixation strategies and bioadhesives for soft bioelectronics. Adv. Funct. Mater. 34, 2313728 (2024).10.1002/adfm.202313728 ↗
56. Yan, Z. et al. Highly stretchable van der Waals thin films for adaptable and breathable electronic membranes. Science 375, 852–859 (2022).10.1126/science.abl8941 ↗
57. Jang, J. et al. Reconfigurable assembly of self-healing stretchable transistors and circuits for integrated systems. Nat. Electron. 8, 474–484 (2025).10.1038/s41928-025-01389-z ↗
58. Yang, X. et al. Role of chemistry in nature-inspired skin adhesives. Chem. Sci. 16, 10665–10690 (2025).10.1039/D5SC01777G ↗
59. Liu, S., Rao, Y., Jang, H., Tan, P. & Lu, N. Strategies for body-conformable electronics. Matter 5, 1104–1136 (2022).10.1016/j.matt.2022.02.006 ↗
60. Seong, D. et al. Sticky and strain-gradient artificial epineurium for sutureless nerve repair in rodents and nonhuman primates. Adv. Mater. 36, e2307810 (2024).10.1002/adma.202307810 ↗
61. Gong, S., Lu, Y., Yin, J., Levin, A. & Cheng, W. Materials-driven soft wearable bioelectronics for connected healthcare. Chem. Rev. 124, 455–553 (2024).10.1021/acs.chemrev.3c00502 ↗
62. Lee, S. et al. A shape-morphing cortex-adhesive sensor for closed-loop transcranial ultrasound neurostimulation. Nat. Electron. 7, 800–814 (2024).10.1038/s41928-024-01240-x ↗
63. Wang, L., Wang, J., Fan, C., Xu, T. & Zhang, X. Skin-like hydrogel-elastomer based electrochemical device for comfortable wearable biofluid monitoring. Chem. Eng. J. 455, 140609 (2023).10.1016/j.cej.2022.140609 ↗
64. Lin, Y., Qiu, W. & Kong, D. Stretchable and body-conformable physical sensors for emerging wearable technology. Sens. Diagn. 3, 1442–1455 (2024).10.1039/D4SD00189C ↗
65. Kim, S., Shin, Y., Han, J., Kim, H. J. & Sunwoo, S. H. Introductory review of soft implantable bioelectronics using conductive and functional hydrogels and hydrogel nanocomposites. Gels 10, 614 (2024).10.3390/gels10100614 ↗
66. Yuk, H., Lu, B. & Zhao, X. Hydrogel bioelectronics. Chem. Soc. Rev. 48, 1642–1667 (2019).10.1039/C8CS00595H ↗
67. Li, Y., Li, N., De Oliveira, N. & Wang, S. Implantable bioelectronics toward long-term stability and sustainability. Matter 4, 1125–1141 (2021).10.1016/j.matt.2021.02.001 ↗
68. Jang, J., Jin, S., Yoon, S., Shin, M. & Son, D. Materials strategy and device fabrication for stable closed-loop bioelectronics. npj Biosensing 2, 27 (2025).10.1038/s44328-025-00045-y ↗
69. Koo, J. H., Song, J.-K., Kim, D.-H. & Son, D. Soft implantable bioelectronics. ACS Mater. Lett. 3, 1528–1540 (2021).10.1021/acsmaterialslett.1c00438 ↗
70. Choi, H. et al. Adhesive bioelectronics for sutureless epicardial interfacing. Nat. Electron. 6, 779–789 (2023).10.1038/s41928-023-01023-w ↗
71. Chen, B. et al. Long-term implantable flexible neural interfaces for electrophysiological monitoring. J. Mater. Chem. C 13, 5951–5980 (2025).10.1039/D4TC04289A ↗
72. Sun, C., Cheng, Z., Abu-Halimah, J. & Tian, B. Perspectives on tissue-like bioelectronics for neural modulation. iScience 26, 106715 (2023).10.1016/j.isci.2023.106715 ↗
73. Niemiec, M. & Kim, K. Lifetime engineering of bioelectronic implants with mechanically reliable thin film encapsulations. Prog. Biomed. Eng. 6, 012001 (2023).10.1088/2516-1091/ad0b19 ↗
74. Trung, T. Q. & Lee, N. E. Flexible and stretchable physical sensor integrated platforms for wearable human-activity monitoring and personal healthcare. Adv. Mater. 28, 4338–4372 (2016).10.1002/adma.201504244 ↗
75. Bao, G. & Suresh, S. Cell and molecular mechanics of biological materials. Nat. Mater. 2, 715–725 (2003).10.1038/nmat1001 ↗
76. Egan, P., Sinko, R., LeDuc, P. R. & Keten, S. The role of mechanics in biological and bio-inspired systems. Nat. Commun. 6, 7418 (2015).10.1038/ncomms8418 ↗
77. Bruck, H., Evans, J. & Peterson, M. The role of mechanics in biological and biologically inspired materials. Exp. Mech. 42, 361–371 (2002).10.1007/BF02412140 ↗
78. Zhai, Q. & Cheng, W. Soft and stretchable electrochemical biosensors. Mater. Today Nano 7, 100041 (2019).10.1016/j.mtnano.2019.100041 ↗
79. Wang, X., Liu, Z. & Zhang, T. Flexible sensing electronics for wearable/attachable health monitoring. Small 13, 1602790 (2017).10.1002/smll.201602790 ↗
80. Qiao, L., Benzigar, M. R., Subramony, J. A., Lovell, N. H. & Liu, G. Advances in sweat wearables: sample extraction, real-time biosensing, and flexible platforms. ACS Appl. Mater. Interfaces 12, 34337–34361 (2020).10.1021/acsami.0c07614 ↗
81. Deo, K. A. et al. Nanoengineered ink for designing 3D printable flexible bioelectronics. ACS Nano 16, 8798–8811 (2022).10.1021/acsnano.1c09386 ↗
82. Su, X. et al. Integrated wearable sensors with bending/stretching selectivity and extremely enhanced sensitivity derived from agarose-based ionic conductor and its 3D-shaping. Chem. Eng. J. 389, 124503 (2020).10.1016/j.cej.2020.124503 ↗
83. Wang, C., Yokota, T. & Someya, T. Natural biopolymer-based biocompatible conductors for stretchable bioelectronics. Chem. Rev. 121, 2109–2146 (2021).10.1021/acs.chemrev.0c00897 ↗
84. Choi, S., Lee, H., Ghaffari, R., Hyeon, T. & Kim, D. H. Recent advances in flexible and stretchable bio-electronic devices integrated with nanomaterials. Adv. Mater. 28, 4203–4218 (2016).10.1002/adma.201504150 ↗
85. Ling, H., Liu, S., Zheng, Z. & Yan, F. Organic flexible electronics. Small Methods 2, 1800070 (2018).10.1002/smtd.201800070 ↗
86. Choi, C. K., English, A. E., Jun, S.-I., Kihm, K. D. & Rack, P. D. An endothelial cell compatible biosensor fabricated using optically thin indium tin oxide silicon nitride electrodes. Biosens. Bioelectron. 22, 2585–2590 (2007).10.1016/j.bios.2006.10.006 ↗
87. Miao, J. & Fan, T. Flexible and stretchable transparent conductive graphene-based electrodes for emerging wearable electronics. Carbon 202, 495–527 (2023).10.1016/j.carbon.2022.11.018 ↗
88. Brennan, D. & Galvin, P. Flexible substrate sensors for multiplex biomarker monitoring. MRS Commun. 8, 627–641 (2018).10.1557/mrc.2018.134 ↗
89. Windmiller, J. R. & Wang, J. Wearable electrochemical sensors and biosensors: a review. Electroanalysis 25, 29–46 (2012).10.1002/elan.201200349 ↗
90. Ashok, A. et al. Flexible nanoarchitectonics for biosensing and physiological monitoring applications. Small 19, 2204946 (2023).10.1002/smll.202204946 ↗
91. Li, Y., Veronica, A., Ma, J. & Nyein, H. Y. Y. Materials, structure, and interface of stretchable interconnects for wearable bioelectronics. Adv. Mater 37, e2408456 (2024).10.1002/adma.202408456 ↗
92. Park, B., Jeong, C., Ok, J. & Kim, T. -i. Materials and structural designs toward motion artifact-free bioelectronics. Chem. Rev. 124, 6148–6197 (2024).10.1021/acs.chemrev.3c00374 ↗
93. Wu, H., Huang, Y., Xu, F., Duan, Y. & Yin, Z. Energy harvesters for wearable and stretchable electronics: from flexibility to stretchability. Adv. Mater. 28, 9881–9919 (2016).10.1002/adma.201602251 ↗
94. Yang, J. C. et al. Geometrically engineered rigid island array for stretchable electronics capable of withstanding various deformation modes. Sci. Adv. 8, eabn3863 (2022).10.1126/sciadv.abn3863 ↗
95. Wang, W. et al. Strain-insensitive intrinsically stretchable transistors and circuits. Nat. Electron. 4, 143–150 (2021).10.1038/s41928-020-00525-1 ↗
96. Brooks, A. K., Chakravarty, S., Ali, M. & Yadavalli, V. K. Kirigami-inspired biodesign for applications in healthcare. Adv. Mater. 34, 2109550 (2022).10.1002/adma.202109550 ↗
97. Xu, R. et al. Kirigami-inspired, highly stretchable micro-supercapacitor patches fabricated by laser conversion and cutting. Microsyst. Nanoeng. 4, 36 (2018).10.1038/s41378-018-0036-z ↗
98. Xiao, Y. et al. High-adhesive flexible electrodes and their manufacture: a review. Micromachines 12, 1505 (2021).10.3390/mi12121505 ↗
99. Zhang, Y. In Stretchable Bioelectronics for Medical Devices and Systems (eds Kim, D. -H., Rogers, J. A. & Ghaffari, R.) Ch. 3 (Springer International Publishing, 2016).
100. Chen, Y. et al. Flexible inorganic bioelectronics. npj Flex Electron. 4, 2 (2020).10.1038/s41528-020-0065-1 ↗