Ag@polydopamine-functionalized borate ester-linked chitosan hydrogel integrates monitoring with wound healing for epidermal sensor
Source abstract
Abstract
Flexible sensors are promising candidates in personalized healthcare, while desired sensors that allow implantation for biomedical applications with optimal sensing and favorable biological properties remain challenges. Here, a multifunctional hydrogel sensor was developed with gallic acid-modified chitosan (CSGA) and 3-carboxyphenylboronic acid-modified chitosan (CSPBA) by encapsulating Ag-decorated polydopamine (Ag@PDA) nanoparticles, namely Ag@PDA-(CSPBA/CSGA). The optimized hydrogel sensor showed desired sensitivity (gauge factor = 2.49), a rapid response/recovery time of 263 ms and good durability. Due to the presence of abundant reactive groups within Ag@PDA-(CSPBA/CSGA), the hydrogel sensor exhibited a comprehensive performance of self-healing, tissue adhesiveness, antioxidative activity, and antibacterial effects against Escherichia coli (92.76%) and Staphylococcus aureus (98.08%). Moreover, the hydrogel sensor could be utilized as a wound dressing, facilitating accelerated wound closure and tissue regeneration. Both subtle activities and large-scale movements could be monitored and distinguished by the hydrogel sensor. This study provides a promising epidermal sensor that offers multifunctionality for health monitoring and wound management.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Electrospun Nanofibers in Biomedical Applications · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (48)
Show source-provided references
1. Wang, Z., Wei, H., Huang, Y., Wei, Y. & Chen, J. Naturally sourced hydrogels: emerging fundamental materials for next-generation healthcare sensing. Chem. Soc. Rev. 52, 2992–3034 (2023).10.1039/D2CS00813K ↗
2. Guo, W. Y. & Ma, M. G. Conductive nanocomposite hydrogels for flexible wearable sensors. J. Mater. Chem. A 12, 9371–9399 (2024).10.1039/D3TA08069B ↗
3. Li, M. et al. Flexible accelerated-wound-healing antibacterial MXene-based epidermic sensor for intelligent wearable human-machine interaction. Adv. Funct. Mater. 32, 2208141 (2022).10.1002/adfm.202208141 ↗
4. Zhang, Y., Zheng, X. T., Zhang, X., Pan, J. & Thean, A. V. Y. Hybrid integration of wearable devices for physiological monitoring. Chem. Rev. 124, 10386–10434 (2024).10.1021/acs.chemrev.3c00471 ↗
5. Ates, H. C. et al. End-to-end design of wearable sensors. Nat. Rev. Mater. 7, 887–907 (2022).10.1038/s41578-022-00460-x ↗
6. Ye, C., Lukas, H., Wang, M., Lee, Y. & Gao, W. Nucleic acid-based wearable and implantable electrochemical sensors. Chem. Soc. Rev. 53, 7960–7982 (2024).10.1039/D4CS00001C ↗
7. Nguyen, N. et al. Engineering an integrated electroactive dressing to accelerate wound healing and monitor noninvasively progress of healing. Nano Energy 99, 107393 (2022).10.1016/j.nanoen.2022.107393 ↗
8. Guo, H. et al. Pro-healing zwitterionic skin sensor enables multi-indicator distinction and continuous real-time monitoring. Adv. Funct. Mater. 31, 2106406 (2021).10.1002/adfm.202106406 ↗
9. Han, J., Yang, J., Gao, W. & Bai, H. Ice-templated, large-area silver nanowire pattern for flexible transparent electrode. Adv. Funct. Mater. 31, 2010155 (2021).10.1002/adfm.202010155 ↗
10. Roh, Y. et al. Crumple-recoverable electronics based on plastic to elastic deformation transitions. Nat. Electron. 7, 66–76 (2024).10.1038/s41928-023-01089-6 ↗
11. Zheng, X. et al. MXene functionalized, highly breathable and sensitive pressure sensors with multi-layered porous structure. Adv. Funct. Mater. 33, 2214880 (2023).10.1002/adfm.202214880 ↗
12. Lu, Y. et al. Stretchable graphene-hydrogel interfaces for wearable and implantable bioelectronics. Nat. Electron. 7, 51–65 (2024).10.1038/s41928-023-01091-y ↗
13. Tan, C. et al. A high performance wearable strain sensor with advanced thermal management for motion monitoring. Nat. Commun. 11, 3530 (2020).10.1038/s41467-020-17301-6 ↗
14. Wei, D., Yang, F., Jiang, Z. & Wang, Z. Flexible iontronics based on 2D nanofluidic material. Nat. Commun. 13, 4965 (2022).10.1038/s41467-022-32699-x ↗
15. He, Y. et al. Multifunctional wearable strain/pressure sensor based on conductive carbon nanotubes/silk nonwoven fabric with high durability and low detection limit. Adv. Compos. Hybrid. Mater. 5, 1939–1950 (2022).10.1007/s42114-022-00525-z ↗
16. Lin, M. et al. A high-performance, sensitive, wearable multifunctional sensor based on rubber/CNT for human motion and skin temperature detection. Adv. Mater. 34, 2107309 (2022).10.1002/adma.202107309 ↗
17. Owens, C. E. et al. Substrate-versatile direct-write printing of carbon nanotube-based flexible conductors, circuits, and sensors. Adv. Funct. Mater. 31, 2100245 (2021).10.1002/adfm.202100245 ↗
18. Huang, J., Li, J., Xu, X., Hua, L. & Lu, Z. In situ loading of polypyrrole onto aramid nanofiber and carbon nanotube aerogel fibers as physiology and motion sensors. ACS Nano 16, 8161–8171 (2022).10.1021/acsnano.2c01540 ↗
19. Tahir, M. et al. Pushing the electrochemical performance limits of polypyrrole toward stable microelectronic devices. Nano-Micro Lett. 15, 49 (2023).10.1007/s40820-023-01027-3 ↗
20. Wei, H. et al. Polypyrrole/reduced graphene aerogel film for wearable piezoresisitic sensors with high sensing performances. Adv. Compos. Hybrid. Mater. 4, 86–95 (2021).10.1007/s42114-020-00201-0 ↗
21. Bai, J. et al. Multifunctional flexible sensor based on PU-TA@ MXene janus architecture for selective direction recognition. Adv. Mater. 35, 2302847 (2023).10.1002/adma.202302847 ↗
22. Cheng, Y. et al. High-strength MXene sheets through interlayer hydrogen bonding for self-healing flexible pressure sensor. Chem. Eng. J. 453, 139823 (2023).10.1016/j.cej.2022.139823 ↗
23. Zhang, Y. et al. Flexible self-powered integrated sensing system with 3D periodic ordered black phosphorus@ MXene thin-films. Adv. Mater. 33, 2007890 (2021).10.1002/adma.202007890 ↗
24. Cai, Y. W. et al. A flexible ultra-sensitive triboelectric tactile sensor of wrinkled PDMS/MXene composite films for E-skin. Nano Energy 81, 105663 (2021).10.1016/j.nanoen.2020.105663 ↗
25. Varghese, H. et al. A high-performance flexible triboelectric nanogenerator based on cellulose acetate nanofibers and micropatterned PDMS films as mechanical energy harvester and self-powered vibrational sensor. Nano Energy 98, 107339 (2022).10.1016/j.nanoen.2022.107339 ↗
26. Gajula, P., Yoon, J. U., Woo, I., Oh, S. J. & Bae, J. W. Triboelectric touch sensor array system for energy generation and self-powered human-machine interfaces based on chemically functionalized, electrospun rGO/Nylon-12 and micro-patterned Ecoflex/MoS2 films. Nano Energy 121, 109278 (2024).10.1016/j.nanoen.2024.109278 ↗
27. Gao, C. et al. Biodegradable Ecoflex encapsulated bacterial cellulose/polypyrrole strain sensor detects motion with high sensitivity, flexibility and scalability. Chem. Eng. J. 460, 141769 (2023).10.1016/j.cej.2023.141769 ↗
28. Zhang, S. et al. 3D printed smart glove with pyramidal MXene/Ecoflex composite-based toroidal triboelectric nanogenerators for wearable human-machine interaction applications. Nano Energy 106, 108110 (2023).10.1016/j.nanoen.2022.108110 ↗
29. Hu, L. et al. Hydrogel-based flexible electronics. Adv. Mater. 35, 2205326 (2023).10.1002/adma.202205326 ↗
30. Ashammakhi, N. et al. Biodegradable implantable sensors: materials design, fabrication, and applications. Adv. Funct. Mater. 31, 2104149 (2021).10.1002/adfm.202104149 ↗
31. Vijayakanth, T. et al. Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels. Chem. Soc. Rev. 52, 6191–6220 (2023).10.1039/D3CS00202K ↗
32. Shirzaei Sani, E. et al. A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds. Sci. Adv. 9, eadf7388 (2023).10.1126/sciadv.adf7388 ↗
33. Kharaziha, M., Baidya, A. & Annabi, N. Rational design of immunomodulatory hydrogels for chronic wound healing. Adv. Mater. 33, 2100176 (2021).10.1002/adma.202100176 ↗
34. Liang, Y., He, J. & Guo, B. Functional hydrogels as wound dressing to enhance wound healing. ACS nano 15, 12687–12722 (2021).10.1021/acsnano.1c04206 ↗
35. Zhu, T. et al. Recent advances in conductive hydrogels: classifications, properties, and applications. Chem. Soc. Rev. 52, 473–509 (2023).10.1039/D2CS00173J ↗
36. Deng, J. et al. Electrical bioadhesive interface for bioelectronics. Nat. Mater. 20, 229–236 (2021).10.1038/s41563-020-00814-2 ↗
37. Pang, Q. et al. Smart flexible electronics-integrated wound dressing for real-time monitoring and on-demand treatment of infected wounds. Adv. Sci. 7, 1902673 (2020).10.1002/advs.201902673 ↗
38. Yan, R. et al. Skin-interfaced self-powered pressure and strain sensors based on fish gelatin-based hydrogel for wireless wound strain and human motion detection. Nano Energy 118, 108932 (2023).10.1016/j.nanoen.2023.108932 ↗
39. Wang, S. et al. Skin-inspired antibacterial conductive hydrogels customized for wireless flexible sensor and collaborative wound healing. J. Mater. Chem. A 11, 14096–14107 (2023).10.1039/D3TA00648D ↗
40. Zhu, J. et al. Smart bioadhesives for wound healing and closure. Bioact. Mater. 19, 360–375 (2023).
41. Li, X. et al. Magnet-oriented hydrogels with mechanical-electrical anisotropy and photothermal antibacterial properties for wound repair and monitoring. Chem. Eng. J. 463, 142387 (2023).10.1016/j.cej.2023.142387 ↗
42. Zhang, H. et al. A conductive multifunctional hydrogel dressing with the synergistic effect of ROS-scavenging and electroactivity for the treatment and sensing of chronic diabetic wounds. Acta Biomater. 167, 348–360 (2023).10.1016/j.actbio.2023.05.045 ↗
43. Qu, X. et al. Skin-inspired highly stretchable, tough and adhesive hydrogels for tissue-attached sensor. Chem. Eng. J. 425, 131523 (2021).10.1016/j.cej.2021.131523 ↗
44. Chen, X. et al. Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species. Chem. Soc. Rev. 45, 2976–3016 (2016).10.1039/C6CS00192K ↗
45. Zhang, C. et al. Mussel-inspired hydrogels: from design principles to promising applications. Chem. Soc. Rev. 49, 3605–3637 (2020).10.1039/C9CS00849G ↗
46. Shin, M., Park, E. & Lee, H. Plant-inspired pyrogallol-containing functional materials. Adv. Funct. Mater. 29, 1903022 (2019).10.1002/adfm.201903022 ↗
47. Guo, Y., Sun, Q., Wu, F. G., Dai, Y. & Chen, X. Polyphenol-containing nanoparticles: synthesis, properties, and therapeutic delivery. Adv. Mater. 33, 2007356 (2021).10.1002/adma.202007356 ↗
48. Makabenta, J. M. V. et al. Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections. Nat. Rev. Microbiol. 19, 23–36 (2021).10.1038/s41579-020-0420-1 ↗